1. Hodgkin's Lymphoma

12. People with hodgkin's lymphoma

16. Classical Hodgkin's Lymphoma : Nodular Sclerosis(2) Classical Hodgkin’s Lymphoma, Nodular Sclerosis: In more advanced cases of Hodgkin’s Lymphoma, several lymph nodes from the same group may become matted together, as seen in this group of mediastinal lymph nodes. Note the anthracotic pigment in some lymph nodes. The specimen measured 12 cm. in greatest dimension

20. Nodular Sclerosis type(in lymph node) In Classical Hodgkin’s Lymphoma, Nodular Sclerosis type, broad collagen bands separate the lymphoid tissue into nodules

22. Classical Hodgkin's Lymphoma : Nodular Sclerosis (Syncytial variant) In some cases of Classical Hodgkin’s Lymphoma, Nodular Sclerosis type, the lacunar cells form cohesive sheets (seen here as lighter staining areas in lymphoid nodules. Such cases have been referred to as syncytial variant. When this feature is pronounced, these cases may be mistakenly diagnosed as non-Hodgkin’s lymphoma, metastatic carcinoma, or even thymoma

23. Classical Hodgkin's Lymphoma : Lymphocyte Depleted A Reed-Sternberg cell is seen in a background of eosinophils, lymphocytes, and macrophages. Lymphocyte-depleted is the most aggressive type of Hodgkin’s lymphoma, commonly associated with advanced stages at presentation

24. Mixed Cellularity High-power view showing numerous Reed-Sternberg cells in this case of Classical Hodgkin’s Lymphoma, Mixed Cellularity type Mixed Cellularity type accounts for 20% to 25% of cases of Classical Hodgkin’s Lymphoma. Reed-Sternberg cells are present in a background of eosinophils, plasma cells, lymphocytes, and atypical mononuclear cells. Fibrosis is usually absent.

25. Nodular Lymphocyte-Predominant Hodgkin's Lymphoma In Nodular Lymphocyte-predominant Hodgkin’s Lymphoma, classic Reed-Sternberg cells, eosinophils, plasma cells, and areas of fibrosis are absent. Instead, numerous L&H cells with multilobed, folded nucleus with small nucleoli are present in a background rich in lymphocytes.

26. Nodular Lymphocyte-Predominant Hodgkin's Lymphoma A close-up of L&H cell (popcorn cell) in a case of Nodular Lymphocyte-predominant Hodgkin’s Lymphoma. It has a large, multilobed, folded nucleus and is surrounded by small lymphocytes. L&H cells are of B-cell lineage and express pan-B-cell markers *(L&H(lymphocyte and histiocytic)