Selenium compounds boost immune system to fight against cancer

1. Selenium
CompoundS booSt
immune SyStem to
fight againSt
CanCer

3. Chemical element
Symbol -- Se
Nonmetal
In small amounts -- key role in metabolism
and also anti-oxidant properties
Too much selenium -- toxic to the body

4. From decades – Garlic and some other
vegetables – anticancer
Researchers found some foods
Anticancer properties
Contain some natural selenium

12. Prostate
CanCer

13. MelanoMa

14. leukeMia

15. Modify the immune response
Modify the immune response
and fight cancers like
and fight cancers like
melanoma, prostate cancer and
certain types of leukaemia
melanoma, prostate cancer and
certain types of leukaemia

16. Immune system is designed to remove things
not normally found in the body.
Cells undergoing change, e.g. precursors of
cancer cells, are therefore normally
recognized and removed by the immune
system.
Unfortunately, the different cancer cells
contain mechanisms that block the immune
system's ability to recognize them, allowing
them to freely continue cancer development.

17. Continue….
Certain cancer cells over express
immunostimulatory molecules in liquid form
 Such over-stimulation -- negative impact
Researchers -- found a way to weaken this
effect through selenium

18. Professor Søren Skov, Department of Veterinary
Disease Biology, University of Copenhagen
“You can say that the stimulating molecules over-activate
the immune system and cause it to
collapse, and we are, of course, interested in
blocking this mechanism. We have now shown
that certain selenium compounds, which are
naturally found in, e.g., garlic and broccoli,
effectively block the special immunostimulatory
molecule that plays a serious role for aggressive
cancers such as melanoma, prostate cancer and
certain types of leukemia"

19. Different Researchers Said,
“For decades, selenium research has been focused
on the identification of active metabolites, which
are crucial for selenium chemoprevention of
cancer. In this context, the metabolite
methylselenol (CH3SeH) is known for its action
to selectively kill transformed cells through
mechanisms that include increased formation of
reactive oxygen species, induction of DNA
damage, triggering of apoptosis, and inhibition of
angiogenesis"

20. In this study, the researchers -- focused on
NGK2D ligands
Eight variants
one in particular has caught the researchers'
attention, because it assumes liquid form
Molecular dissolution that causes serious
problems, once the cancer is raging.
Entire bloodstream – infected
Molecule -- marker of serious illness

21. Professor Søren Skov, Department of Veterinary
Disease Biology, University of Copenhagen
"Molecules (Ligands) are found both on the
surface of the cancer cells and dissolved in the
blood of the affected person. We are now able
to show that selenium compounds appear to
have a very beneficial effect when it comes to
neutralizing the special variant of the NGK2D
ligand -- both in soluble form and when the
molecule is placed on the cell surface"

22. The researchers are constantly learning
more about the disease mechanisms causing
aggressive cancers in the skin, blood and
reproductive organs

23. Professor Søren Skov, Department of Veterinary
Disease Biology, University of Copenhagen
“The over expression seen in cancers such as
melanoma, prostate cancer and certain types of
leukemia significantly impairs the immune
system. If we can find ways to slow down the
over-stimulation, we are on the right track.
The new results are yet another small step
towards better cancer drugs with fewer
adverse effects”

24. The study received support from the Danish
Council for Independent Research and the
European Marie Curie Initial Training Network.
Aside from Skov, other authors include:
 Bente Gammelgaard
 Lars Ellgaard
 Charlotte Gabel-Jensen
 Lars Andresen
 Stephanie Kehlet
 Franziska Uhlenbrock
 Michael Hagemann-Jensen

25. A balanced diet with a variety of vegetables can
reduce risk of cancer