5.
های باکتری روی بر تاثیرGram +وGram –
برای بهترmixed infections
May give up some effectiveness for Gram + to gain
effectiveness for Gram -.
مثال
Amoxicillin, Ampicillin
Broad Spectrum Antibiotics
10. Rx:
Drug Name (can be generic) Unit Dose
(ex: Pen V-K 500 mg, Elixer, Sol’n)
Disp: # of pills, milliliters (ml)
Sig: Directions for use. q24h (daily), q12h, q8h, q6h, q4h,
prn pain, till gone
Refills__ Signature
DEA #
11. Dental Clinic
Pt. Name: Address: DOB:
Rx: Date:
Disp:
Sig:
Refill____ Hadi Hoseini, omfs
DEA:______________________
12. Dental Clinic
Pt. Name: Address: DOB:
Rx: Date:
Refill____ Hadi Hoseini, omfs
DEA:______________________
16. CHARACTERISTIC CELLULITIS ABSCESS
Duration Acute Chronic
Pain Severe and generalized Localized
Size Large Small
Localization Diffuse borders Well circumscribed
Palpation Doughy to indurated Fluctuant
Presence of pus No Yes
Bacteria Aerobic Anaerobic
Cellulitis Vs Abscess
28. BASED ON BODY SURFACE AREA
Individual dose = BSA[m2] x adult dose
1.7
BASED ON BODY WEIGHT
Individual dose = BW[kg] x average
70 adult dose
YOUNG’S CHILD FORMULA :
DOSE = Age x adult dose
Age + 12
DILLING’S CHILD FORMULA :
DOSE = Age x adult dose
20
دوز تعیین
32.
اصلی فرم سه
1. Chromosome mediated
1. Spontaneous mutations
2. Non-major form of drug resistance
3. Rarely lead to complete resistance
2. Plasmid mediated (conjugation)
1. VERY important from clinical standpoint
2. Mostly gram negs
3. Mediate resistance to multiple drugs
4. High transfer rate from cell to cell
3. Transposon (transduction and transformation)
1. Phage mediated
2. Clinically important for Gram +
Resistance
42.
کلیندامایسینClindamycin (Cleocin)
اثر مکانیسم:
binds to the 50S ribosomal subunit and inhibits protein
synthesis
دوز:100-450mg q 6 h x 7-10 days
مصرف منع
هپاتت فانکشن مشکل
نامطلوب اثرات:گوارشی نارحتی–سودوممبران کولیت
دارویی تداخالت:neuromuscular blocking agents
Pregnancy category B
Lincosamides
69.
آسیکلوویرAcyclovir (Zovirax)
نامطلوب های واکنش:
موضعی مصرف:
produces burning, stinging, or mild pain in about one third of
patients
دهانی مصرف:
headache (13%) is one of the most common; other central nervous
system (CNS) and GI effects
تزریقی مصرف:
local reactions at the injection site are the most common
ویروس ضد داروهای
78.
Age, allergies, compliance, pregnancy risk
Patient function
Renal, hepatic, immunosuppresion, route applicability
Cost
Brand name, length of course, made in
بیمار به مربوط فاکتورهای
79. Dental Infection
Acute—Rapid growth
< 3 days
Chronic > 3 days
Pen VK 500mg q6h or
Amox 500mg q8h or
Cephalosporin
Allergic to PCN
Clindamycin 300mg q8h or
Cephalosporin (check allergic Rxn) or
Azith or Clarithromycin
Think Anaerobes
Add Metronidazole 250-500mg
To PCN, Amox, or Ceph
Clindamycin 300mg q8h