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Nephrotic syndrome
1.
By: Hamza AlGhamdi
2.
NORMAL KIDNEY’S PHYSIOLOGY
AND HISTOLOGY
3.
Capillary Space Endothelium
Urinary Space GBM Podocyte
4.
NORMAL KIDNEY HISTOLOGY
5.
Parietal Epithelium Visceral
Epithelium Capillary Lumen Mesangial Cell Basement Membrane (GBM) Urinary Space RBC Endothelial Cell
6.
NEPHROTIC SYNDROME IS
NOT A DISEASE
7.
8.
Periorbital edema Pitting
edema of lower limbs
9.
10.
11.
12.
13.
14.
15.
16.
17.
18.
Membranous GN Sub-epithelial
immune Complex deposits Thickened GBM
19.
Membranous GN
H&E
20.
Membranous GN
IF
21.
Capillary Lumen GBM
GBM Membranous GN EM
22.
23.
24.
MINIMAL CHANGE DISEASE
Foot Process Fusion
25.
26.
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29.
FSGS H&E
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32.
Figure 8.
Pathology of membranoproliferative glomerulonephritis type I. (a) Light microscopy shows a hypercellular glomerulus with accentuated lobular architecture and a small cellular crescent (methenamine silver).
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