1. Cancer of thenasopharynx BY Dr , Ibrahim HabibBarakat M.D. ( E.N.T.) salamatuall@yahoo.com www.facebook.com/Dr.Ibrahim.Barakat
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4. Epidemiology of nasopharyngeal ca. Incidence : Rare o.6 per 100,000 l yr in U S A Southern China is 50 times > U S A ِ Age : 4TH to 5th decade Sex : male : female 2 to 3 : 1 Etiology : Multifactorial : Viral , dietry , occupational , cigarette smoking
8. Anatomy of the nasopharynx Anterior : post. Nasal choana , nasal septum Post : 2 cervical vertebrae , prevertebral and buccopharyngeal fascia Sup: basisephenoid , basioccipt Inf : sup . Surface of soft palate Lateral : maxilloph. Space , pterigoid plate, paraph. Space
11. Fossa of Rosenmuller Eustachian tube opens in lateral wall of the nasopharynex , surrounded by torus tubarius ( cartilagenous elevation ) . A recess behind torus tubarius is called Rosenmuller fossa . Clinical importance : location for cancer to arise .
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13. Blood supply of nasopharynx Arterial : branches from E.C.A. Venous : pharyangeal plexus to I.J.V.
14. Nerve supply of nasopharynx Branches from cranial nerve V2 , IX , X . Sympathetic n.
15. Lymphatic drainage of the nasopharynx Retropharyngeal . Parapharyngeal . Jugular chain . L . N . Of spinal accesory chain in posterior triangle. Supraclavicular L . N . Contralateral neck.
16. Epithelial lining of nasopharynx 60% of nasopharynx is lined with Stratified squamous epithelium
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18. Spread of nasopharyngeal ca. Ant : nasal cavity , paranasal sinuses , pterigopalatine fossa, orbital apex . Inferiorly : oropharynx. Superiorly : skull base , sphenoid body & sinus. Laterally : paraph. , pterigoid structures.
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21. Pathology of tumors of nasopharynx Epithelial benign Epithelial malignant Papilloma Pleomorphic adenoma Oncocytoma Basal cell adenoma Ectopic pituitary adenoma Nasopharyngeal carcinoma. 1- Squamous cell ca. 2- Non keatinizing ca. 3- Undifferentiated ca. Adenocarcinoma. Papillary adenocarcinoma. Mucoepidermoid carcinoma. Adenoid cyctic ca. Polymorph low grade adeno ca.
33. Cranial neuropathies in N.PH.ca Cn VI most frequently affected . Cn ( II toVI ) Jacod’s syndrome due to cavernus sinus invasion . Cn ( IX – XII ) & sympathetic n. Villaret’s syndrome retropharyngeal invasion
34. 5years boy presented with neck mass . On examination he had nasopharyngeal mass on the same side ( left )
52. investigation laboratory radiological .c.b.c. ca , PO4 , alkaline phosphate. Urin analysis Liver function Kidney function Serum IgA E.B.V. caspid antigen EBV DNA X- ray chest C.T. scan M R I P .E .T. Bone scintigraphy
61. Staging system for n.ph.caT stage TX : primary tumor can’t be assessed . TO : no evidence of primary tumor . Tis : carcinoma in situ .
62. Staging systems for N . Ph . Ca. T stage( 1ry tumour extent) T1 confined to nasopharynx T2 extend to oropharynx or nasal cavity a without parapharyngeal extention B with parapharyngeal extention T3 invade bones or PNS T4 involvement of cranial nerves , intracranial content , infratemporal fossa , hypopharynx , orbit
63. N stage lymph node disease N0 No L . N . Metastasis . N1 unilateral L . N (s) < or = 6 cm N2 bilateral L . N (s) < or = 6 cm N3 3a L . N (s) > 6 cm 3b with extension to supraclavicular fossa
64. M stage distant metastasis M0 abscent M1 present
75. PROGNOSIS Well differentiated n. ph. Ca. has poorer local control rates. Advanced undifferentiated n. ph. Ca. has higher distant metastasis . .Accepted 5 years survival rate is ( 40 %– 50 %) Better result in female patient under age of 40 Very poor prognosis in pregnancy concurrent within 1st year of treatment. Relapse and distant failure occurs within the 1st 2 or 3 years