The lymphatic system drains tissue fluid, plasma proteins, and cellular debris from the lower limb into lymph vessels. The lymph is then filtered by lymph nodes and directed into the venous system. There are superficial and deep lymphatic vessels in the lower limb. The superficial vessels follow the great and small saphenous veins, while the deep vessels accompany the anterior tibial, posterior tibial, and peroneal arteries and drain into the popliteal lymph nodes. Lymphadenopathy is abnormal swelling of lymph nodes, usually due to infection, malignancy, or autoimmune conditions. Enlarged inguinal lymph nodes could indicate issues with the lower limb or genital region.