Genes oncogenes in oral cancer genesis /certified fixed orthodontic courses by Indian dental academy
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Genes oncogenes in oral cancer genesis /certified fixed orthodontic courses by Indian dental academy
- 1. GENES -Oncogenes in oral cancer genesis INDIAN DENTAL ACADEMY Leader in continuing dental education www.indiandentalacademy.com www.indiandentalacademy.com
- 6. Head and neck cancer Dominant - the genes have been termed proto-oncogenes. Recessive – the genes variously termed anti-oncogenes. www.indiandentalacademy.com
- 7. Definition Proto-oncogenes are normal cellular genes that are involved in the control of cell proliferation or differentiation. www.indiandentalacademy.com
- 9. Definition Oncogene is a sequence of deoxyribonucleic acid that has been altered or mutated from its original form, the proto-oncogene. www.indiandentalacademy.com
- 14. Oncoproteins Oncogenes encode proteins called oncoproteins which resemble the normal products of the proto-oncogenes with exception that the, Oncoproteins are devoid of important regulatory elements and Their production does not depend on growth factors or external signals www.indiandentalacademy.com
- 17. Mechanism of oncogene activation Viruses Point mutations Chromosome rearrangements Gene amplifications www.indiandentalacademy.com
- 37. Oncogenes in oral cancer www.indiandentalacademy.com
- 40. c-myc High metastatic potential Poor response to chemotherapy www.indiandentalacademy.com
- 41. ras family • Four classes – H-ras – Ka-ras – Kb-ras – N-ras www.indiandentalacademy.com
- 44. erb2 in oral cancer Overexpression – poorly differentiated carcinomas, lymph node metastasis, shortened survival period www.indiandentalacademy.com
- 47. Additional oncogenes in oral cancer Ets1 Wt pin Bcl1 – int2 – hst – amplicon unit Amplification – aggressiveness -Regional nodal involvement Eiaf – ets1 family – increased MMP’sinvasive potential www.indiandentalacademy.com