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Translational Research strategies in
CIC bioGUNE
Arkaitz Carracedo
Investigación e innovación en salud en Euskadi
What does it mean To be translational?
What does it mean To be translational?
What does it mean To be translational?
2 models to approach a translational strategy:
Model 1: Synergy by proximity Model ...
The AC lab Translational strategy
CIC bioGUNE: A technological Research center for cooperative Research
-Bioscience instit...
The AC lab Translational strategy
Translational SWOT analysis of CIC bioGUNE
WEAKNESSES
Location: Long distance from local...
The AC lab Translational strategy
Definition: A technological Research center for cooperative Research
Traslational fitness: How to get there
The AC lab strategy
How to turn Weaknesses into Opportunities
Traslational fitness: How to get there
Cancer
discussion group
The AC lab strategy
Traslational fitness: How to get there
The AC lab strategy
Biobank
2011: Strategic Alliance
AC
Pathologist
Urologists
Loca...
Traslational fitness: How to get there
The AC lab strategy
Biobank
2011: Strategic Alliance AC Lab : Basque Biobank
Aims:
...
Traslational fitness: How to get there
The AC lab strategy
Biobank: Achievements
AC
Traslational fitness: How to get there
The AC lab strategy
Biobank: Achievements
Pathologist
Urologists
Prostate Cancer...
The AC lab strategy
Computational biology
Traslational fitness: How to get there
The AC lab strategy
Computational biology
2014: Collaborative initiative with Genomics Platform
Aims:
To train informatici...
Liquid biopsy
*Strategic alliances with OMICs labs
Integration of experimental and
observational models
Mouse models of ca...
An example: Biomarker search in PCa
The advantage of CIC bioGUNE: OMICs
OMICs that are good for biomarker Discovery
Transcriptomics
Peptidomics
NMR metabolomi...
The advantage of CIC bioGUNE: OMICs
Urine extracelular vesicles
An example: Biomarker search in PCa
Hiperplasia
benigna
Adenocarcinoma
de próstata
The advantage of CIC bioGUNE: OMICs
Urine extracelular vesicles
An example:...
Hiperplasia
benigna
Adenocarcinoma
de próstata
The advantage of CIC bioGUNE: OMICs
Urine extracelular vesicles
Urine CDH3 ...
The advantage of CIC bioGUNE: OMICs
Perspective: Do urine exosomes “inform” about the molecular
make up of PCa?
Tumor alte...
An example: Precision medicine in cancer
WHO will develop aggressive disease?
HOW is PCa aggressiveness controlled?
Relevant questions for the urologists
Selection criteria:
-Consistently altered throughout datasets
-Associated to disease aggressiveness
An example: Precision ...
An example: Precision medicine in cancer
The AC lab strategy
Discussion group on cancer
Traslational fitness: How to get there
Cancer
discussion group
The AC lab strategy
Discussion group on cancer
2014: Created in answer to the following needs:
Loss of Perspective in Rese...
The AC lab strategy
Discussion group on cancer
Cancer as a compendium
of diseases
Clinical testing of drugs
Biobanking
Nut...
Thank you!
Collaborations
J. Falcón (SPA)
JL. Iovanna (FRA)
R. Gomis (SPA)
C.Cordon (USA)
P. Pinton (ITA)
R. Barrio (BIO)
...
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Translational Research strategies in CIC bioGUNE

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Presentación de Arkaitz Carracedo del CIC bioGUNE en el Martes de Innobasque "Investigación en salud en Euskadi" celebrado en el edificio Ledo de Bilbao el 26 de abril de 2016.

Publicado en: Salud y medicina
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Translational Research strategies in CIC bioGUNE

  1. 1. Translational Research strategies in CIC bioGUNE Arkaitz Carracedo Investigación e innovación en salud en Euskadi
  2. 2. What does it mean To be translational?
  3. 3. What does it mean To be translational?
  4. 4. What does it mean To be translational? 2 models to approach a translational strategy: Model 1: Synergy by proximity Model 2: Synergy by strategy
  5. 5. The AC lab Translational strategy CIC bioGUNE: A technological Research center for cooperative Research -Bioscience institute -Spirit-headed by the Department of Industry -Conceived to translate basic Research into health-related commercial strategies
  6. 6. The AC lab Translational strategy Translational SWOT analysis of CIC bioGUNE WEAKNESSES Location: Long distance from local hospital
  7. 7. The AC lab Translational strategy Definition: A technological Research center for cooperative Research
  8. 8. Traslational fitness: How to get there The AC lab strategy How to turn Weaknesses into Opportunities
  9. 9. Traslational fitness: How to get there Cancer discussion group The AC lab strategy
  10. 10. Traslational fitness: How to get there The AC lab strategy Biobank 2011: Strategic Alliance AC Pathologist Urologists Local National MSSM Basurto Donostia Others…
  11. 11. Traslational fitness: How to get there The AC lab strategy Biobank 2011: Strategic Alliance AC Lab : Basque Biobank Aims: To increase the visibility of biobanking in the Basque Country To spirit-head a Prostate Cancer prospective study as proof-of-concept To collaborate in methodological advances to improve sample acquisition and processing
  12. 12. Traslational fitness: How to get there The AC lab strategy Biobank: Achievements
  13. 13. AC Traslational fitness: How to get there The AC lab strategy Biobank: Achievements Pathologist Urologists Prostate Cancer Hyperplasia Scheduled for surgery – informed consent Week before surgery Day of surgery Paraffin-embedded tissue Fresh-frozen diagnosed tissue Fasting serum, plasma, urine and blood DNA Physical parameters and blood biochemistry 2012-2016: 800 patients enrolled Follow up, association studies of recurrence Outcome: -6 publications -1 patent -2 collaborations with Pharmas for product validation
  14. 14. The AC lab strategy Computational biology Traslational fitness: How to get there
  15. 15. The AC lab strategy Computational biology 2014: Collaborative initiative with Genomics Platform Aims: To train informatician / statistician in biological informatics To exploit publicly accessible cancer datasets To develop a webtool to potentiate computational biology in untrained basic scientists Traslational fitness: How to get there
  16. 16. Liquid biopsy *Strategic alliances with OMICs labs Integration of experimental and observational models Mouse models of cancer Patient specimens Molecular and celular biology PlasmaUrine
  17. 17. An example: Biomarker search in PCa
  18. 18. The advantage of CIC bioGUNE: OMICs OMICs that are good for biomarker Discovery Transcriptomics Peptidomics NMR metabolomics An example: Biomarker search in PCa
  19. 19. The advantage of CIC bioGUNE: OMICs Urine extracelular vesicles An example: Biomarker search in PCa
  20. 20. Hiperplasia benigna Adenocarcinoma de próstata The advantage of CIC bioGUNE: OMICs Urine extracelular vesicles An example: Biomarker search in PCa
  21. 21. Hiperplasia benigna Adenocarcinoma de próstata The advantage of CIC bioGUNE: OMICs Urine extracelular vesicles Urine CDH3 mRNA An example: Biomarker search in PCa
  22. 22. The advantage of CIC bioGUNE: OMICs Perspective: Do urine exosomes “inform” about the molecular make up of PCa? Tumor alterations Urine alterations An example: Biomarker search in PCa
  23. 23. An example: Precision medicine in cancer
  24. 24. WHO will develop aggressive disease? HOW is PCa aggressiveness controlled? Relevant questions for the urologists
  25. 25. Selection criteria: -Consistently altered throughout datasets -Associated to disease aggressiveness An example: Precision medicine in cancer
  26. 26. An example: Precision medicine in cancer
  27. 27. The AC lab strategy Discussion group on cancer Traslational fitness: How to get there Cancer discussion group
  28. 28. The AC lab strategy Discussion group on cancer 2014: Created in answer to the following needs: Loss of Perspective in Research: To remember who the enemy is Relevant question often come from other participants in the disease Dissemination of Research is of essence to scientific wellness Traslational fitness: How to get there Cancer discussion group
  29. 29. The AC lab strategy Discussion group on cancer Cancer as a compendium of diseases Clinical testing of drugs Biobanking Nutrition and cancer Biomarkers Psychological treatment Patient advocacy Testimony Ethics in science Traslational fitness: How to get there Oncologists Advocates Patients Scientists Psychologists Journalists Nurses Clinicians
  30. 30. Thank you! Collaborations J. Falcón (SPA) JL. Iovanna (FRA) R. Gomis (SPA) C.Cordon (USA) P. Pinton (ITA) R. Barrio (BIO) H.U.Basurto Servicio de Urología Servicio de Patología Servicio de enfermería Biobanco

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