マラソン当日の操作について

•

0 j'aime•780 vues

Katsuyoshi Ito

iPhoneアプリ「ゴールイン！」の使い方です。マラソン大会当日の操作についての説明です。

Santé & Médecine

ITO SOFT DESIGN Inc.
http://iphone.itosoft.com/

2011 2 3

Contenu connexe

En vedette

Export data

Katsuyoshi Ito

ABSTRACT The main objective of present research work is to formulate the floating tablets of Carvedilol Phosphate using 32 factorial design. Carvedilol Phosphate, non-selective α1-β1-blocking agent belongs to BCS Class-II and Indicated for treatment of Hypertension/moderate Heart Failure. The Floating tablets of Carvedilol Phosphate were prepared employing different concentrations of HPMCK100M and Sodium bicarbonate in different combinations by Direct Compression technique using 32 factorial design. The concentration of HPMCK100M and Sodium bicarbonate required to achieve desired drug release was selected as independent variables, X1 and X2 respectively whereas, time required for 10% of drug dissolution (t10%), 50% (t50%), 75% (t75%) and 90% (t90%) were selected as dependent variables. Totally nine formulations were designed and are evaluated for hardness, friability, thickness, % drug content, Floating Lag time, In-vitro drug release. From the Results concluded that all the formulation were found to be with in the Pharmacopoeial limits and the In-vitro dissolution profiles of all formulations were fitted in to different Kinetic models, the statistical parameters like intercept (a), slope (b) & regression coefficient (r) were calculated. Polynomial equations were developed for t10%, t50%, t75%, t90%. Validity of developed polynomial equations were verified by designing 2 check point formulations (C1, C2). According to SUPAC guidelines the formulation (F8) containing combination of 25% HPMCK100M and 3.75% Sodium bicarbonate, is the most similar formulation (similarity factor f2=88.801, dissimilarity factor f1= 2.250 & No significant difference, t= 0.095) to marketed product (CARDIVAS). The selected formulation (F8) follows Higuchi’s kinetics, and the mechanism

Formulation Design, Optimization and Evaluation of Carvedilol Phosphate Gastr...

Dr. Raghavendra Kumar Gunda

The main objective of present investigation is to formulate the floating tablets of Ranitidine.HCl using 32 factorial design. Ranitidine.HCl, H2-receptor antagonist belongs to BCS Class-III. The Floating tablets of Ranitidine.HCl were prepared employing different concentrations of HPMCK4M and Guar Gum in different combinations as a release rate modifiers by Direct Compression technique using 32 factorial design. The concentration of Polymers , HPMCK4M and Guar Gum required to achieve desired drug release was selected as independent variables, X1 and X2 respectively whereas, time required for 10% of drug dissolution (t10%), 50% (t50%), 75% (t75%) and 90% (t90%) were selected as dependent variables. Totally nine formulations were designed and are evaluated for hardness, friability, thickness, % drug content, Floating Lag time, In-vitro drug release. From the Results concluded that all the formulation were found to be within the Pharmacopoeial limits and the In-vitro dissolution profiles of all formulations were fitted in to different Kinetic models, the statistical parameters like intercept (a), slope (b) & regression coefficient (r) were calculated. Polynomial equations were developed for t10%, t50%, t75%, t90%. Validity of developed polynomial equations were verified by designing 2 check point formulations(C1, C2). According to SUPAC guidelines the formulation (F5) containing combination of 22.5% HPMCK4M and 22.5% Guar Gum, is the most similar formulation (similarity factor f2=85.01, dissimilarity factor f1= 15.358 & No significant difference, t= 0.169) to marketed product (ZANTAC). The selected formulation (F5) follows Higuchi’s kinetics, and the mechanism of drug release was found to be Non-Fickian Diffusion (n= 0.922).

Design Formulation and Evaluation of Ranitidine HCl Gastro Retentive Floating...

Dr. Raghavendra Kumar Gunda

ABSTRACT The main objective of present investigation is to formulate the sustained release tablet of Metoprolol Succinate using 32 factorial design. Metoprolol Succinate, is a selective β1blocker, to treat Hypertension & Heart Failure. The SR tablets of Metoprolol Succinate were prepared employing different concentrations of HPMCK15M and HPMCK100M in different combinations as a rate retardants by Direct Compression technique using 32 factorial design. The quantity of rate retarders, HPMCK15M and HPMCK100M required to achieve the desired drug release was selected as independent variables, X1 and X2 respectively whereas, time required for 10% of drug dissolution (t10%), 50% (t50%), 75% (t75%) and 90% (t90%) were selected as dependent variables. Totally nine formulations were designed and are evaluated for hardness, friability, thickness, % drug content, In-vitro drug release. From the Results it was concluded that all the formulation were found to be with in the Pharmacopoeial limits and the Invitro dissolution profiles of all formulations were fitted in to different Kinetic models, the statistical parameters like intercept (a), slope (b) & regression coefficient (r) were calculated. Polynomial equations were developed for t10%, t50%, t75%, t90%. Validity of developed polynomial equations were verified by designing 2 check point formulations(C1, C2). According to SUPAC guidelines the formulation (F5) containing combination of 10% HPMCK15M and 10% HPMCK100M, is the most similar formulation (f2=92.38 & No significant difference, t= 0.0216) to marketed product (Metocard). The selected formulation (F5) follows Higuchi’s kinetics, the mechanism of drug release was found to be Super case II transport (Non-Fickian, n= 0.981).

Formulation development and evaluation of metoprolol succinate sustained rele...

Dr. Raghavendra Kumar Gunda

Abstract The main objective of present research work is to formulate the floating tablets of atenolol using 32 factorial design. Atenolol, β-blocker belongs to Biopharmaceutical Classification System Class-III. The floating tablets of atenolol were prepared employing different concentrations of hydroxypropyl methylcellulose (HPMC) K15M and sodium bicarbonate in different combinations by direct compression technique using 32 factorial design. The concentration of HPMC K15M and sodium bicarbonate required to achieve desired drug release was selected as independent variables, X1 and X2, respectively, whereas time required for 10% of drug dissolution (t10%), 50% (t50%), 75% (t75%), and 90% (t90%) were selected as dependent variables. Totally, nine formulations were designed and are evaluated for hardness, friability, thickness, % drug content, floating lag time, in vitro drug release. From the results, concluded that all the formulation were found to be within the pharmacopoeial limits and the in vitro dissolution profiles of all formulations were fitted into different Kinetic models, the statistical parameters like intercept (a), slope (b) and regression coefficient (r) were calculated. Polynomial equations were developed for t10%, t50%, t75%, t90%. Validity of developed polynomial equations was verified by designing 2 checkpoint formulations (C1, C2). According to SUPAC guidelines the formulation (F8) containing combination of 25% HPMC K15M and 3.75% sodium bicarbonate, is the most similar formulation (similarity factor f2 = 87.797, dissimilarity factor f1 = 2.248 and no significant difference, t = 0.098) to marketed product (BETACARD). The selected formulation (F8) follows Higuchi’s kinetics, and the mechanism of drug release was found to be non-Fickian diffusion (n = 1.029, Super Case-II transport).

Design, Formulation and Evaluation of Atenolol Gastro Retentive Floating Tablets

Dr. Raghavendra Kumar Gunda

Ocdds upp

Dr. Raghavendra Kumar Gunda

Buccaldrugdeliverysystem

Dr. Raghavendra Kumar Gunda

Background: The main objective of present research work is to formulate the Carbamazepine Fast Dissoving tablets. Carbamazepine, an antiepileptic, belongs to BCS Class-II and used to control some types of seizures in the treatment of epilepsy and Neuropathic Pain by blocking use-dependent sodium channels. Methods: The Fast Dissoving tablets of Carbamazepine were prepared employing different concentrations of Crospovidone and Croscarmellose sodium in different combinations as a Sperdisintegrants by Direct Compression technique using 32 factorial design. The concentration of Crospovidone and Croscarmellose sodium was selected as independent variables, X1 and X2 respectively whereas, wetting time, Disintegration time, t 50% ,t90%were selected as dependent variables. Results and Discussion: Totally nine formulations were designed and are evaluated for hardness, friability, thickness, Assay, Wetting time, Disintegration time, Invitro drug release. From the Results concluded that all the formulation were found to be with in the Pharmacopoeial limits and the In-vitro dissolution profiles of all formulations were fitted in to different Kinetic models, the statistical parameters like intercept (a), slope (b) & regression coefficient (r) were calculated. Polynomial equations were developed for Wetting time, Disintegration time, t50%, t90%. Validity of developed polynomial equations were verified by designing 2 check point formulations (C1 , C2 ). According to SUPAC guidelines the formulation (F5 ) containing combination of 9.375% Crospovidone and 9.375% Croscarmellose, is the most similar formulation (similarity factor f 2 =82.675, dissimilarity factor f1 = 2.049 & No significant difference, t= 0.041) to marketed product (TEGRETOL-100). Conclusion: The selected formulation (F5 ) follows First order, Higuchi’s kinetics, mechanism of drug release was found to be Non-Fickian Diffusion (n= 0.665). KEYWORDS: Carbamazepine, 3 2Factorial Design, Crospovidone , croscarmellose Sodium, Wetting Time, Disintegration Time.

Formulation Development and Evaluation of Carbamazepine Fast Dissolving Tablets

Dr. Raghavendra Kumar Gunda

Bio adhesive dds

Dr. Raghavendra Kumar Gunda

Terapia Cognitivo Comportamental dos Transtornos da Personalidade

Eduardo Moreira

En vedette (10)

Export data

Formulation Design, Optimization and Evaluation of Carvedilol Phosphate Gastr...

Design Formulation and Evaluation of Ranitidine HCl Gastro Retentive Floating...

Formulation development and evaluation of metoprolol succinate sustained rele...

Design, Formulation and Evaluation of Atenolol Gastro Retentive Floating Tablets

Ocdds upp

Buccaldrugdeliverysystem

Formulation Development and Evaluation of Carbamazepine Fast Dissolving Tablets

Bio adhesive dds

Terapia Cognitivo Comportamental dos Transtornos da Personalidade

Dernier

Histologie de la Cavité Buccale (Chapitre 1/3 de l'Histologie du l'appareil d...

nadirmiry1

Massage japonais notre présentation powerpoint

Massage Guide

Histologie des Glandes Annexes Digestives (Chapitre 3/3 de l'Histologie du l'...

nadirmiry1

présentation PowerPoint sur les technique d'anesthésie en neurochirurgie.ppt

lailaelhaddaoui1

cours sous forme de présentation PowerPoint anesthesie hors bloc .pdf

lailaelhaddaoui1

LES HÉMOPHILIES.pptx pour les étudiants.

BallaMoussaDidhiou

cours de Sclérose en plaque partie 1 .pptx

yaminahamidi2

13-Partenariat Public Privé dans le domaine de santé.pdf

saidisoundos2

Histologie du Tube Digestif (Chapitre 2/3 de l'Histologie du l'appareil diges...

nadirmiry1

Dernier (9)

Histologie de la Cavité Buccale (Chapitre 1/3 de l'Histologie du l'appareil d...

Massage japonais notre présentation powerpoint

Histologie des Glandes Annexes Digestives (Chapitre 3/3 de l'Histologie du l'...

présentation PowerPoint sur les technique d'anesthésie en neurochirurgie.ppt

cours sous forme de présentation PowerPoint anesthesie hors bloc .pdf

LES HÉMOPHILIES.pptx pour les étudiants.

cours de Sclérose en plaque partie 1 .pptx

13-Partenariat Public Privé dans le domaine de santé.pdf

Histologie du Tube Digestif (Chapitre 2/3 de l'Histologie du l'appareil diges...