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Developing customizable smartphone
 and web applications for doctorsto
 personalizepatient engagement in
      chronic care situations.



              Confidential            @RxApps
The Inspiration




                                 Mom



                  Confidential     @RxApps
The pattern – Repeated in College




      Doctors miss things by no fault of their own
        Medications do not workby themselves
                       Confidential                  @RxApps
Treatment Follow Up is inconsistent

                                    Only 20% make recommended follow
                                    up appointments during first 3 months




                                    60% of Patients adherent at 3 months




                                    43% Adherent at 6 months



          ~50% Overall Adherence Long Term

                     Confidential                                   @RxApps
IMAGINE A NEW CARE
CONTINUUM…

            Confidential   @RxApps
Doctor gives diagnosis
and ‘prescription’ to
set up account




               Confidential   @RxApps
Profile – Set up by Patient
Web




      (S)




                   Confidential   @RxApps
Use Walkthrough
   Customize   Prompt and Respond   View History




                  Confidential                 @RxApps
Built in logic




                            OR
                                       617.555.5656
                                        917.665.7272
                                             911




                                      Irregular, Alarming
     Normal, Healthy
                       Confidential                     @RxApps
Doctor can monitor in real
   time and easily reach out;
   change questions on the fly




Confidential            @RxApps
Provider Dashboard and Registry


                                 Patients will eventually
                                 be prioritized based on
                                 severity of condition at
                                 last check in (trending
                                 patterns also taken
                                 into account)




                  Confidential                    @RxApps
Better Treatment

                    80% of patients in weekly communication
                     with care team had medication changed
                   within 60 days vs 15% in treatment as usual




Treatment Adjustment and Medication Adherence for Complex Patients With Diabetes, Heart Disease, and Depression:
A Randomized Controlled Trial
Lin, EHB, et al. (2012) Annals of Family Medicine 10:6-14.

                                                 Confidential                                         @RxApps
Better self-management

“Doctor engagement outside of care
settingincreases adherence by 33%”




               Confidential    @RxApps
*




                     *
                 *




     Over $28 B in savings for MH Alone
ImprovedQOL, Management of other Conditions
                     Confidential       @RxApps
Accountable Care Organizations (ACO) want
Monitoring




                      Monitoring
                 Predictive Analytics
              Simple, Intuitive interfaces


                       Confidential          @RxApps
HITECH/EMRs                             ACO/PPACA
Tech Reform          Mobile           Payment Reform
      Market factors aligned for the first time
Prescribable Apps      Confidential            @RxApps
Benefits of Use
    Patients
        Higher quality of life
    Providers and Concierge Care Systems
        Competitive advantage
        Opportunity for increased revenue
    Large Hospital Systems (ACOs, IDNs)
        Population management
        Shared Savings Program quality reporting

                          Confidential          @RxApps
Revenue: Per member per month subscription

                    Scenario 1 – Focus:
               Only past inpatient/ED history
       At $10/mo:                  $36,000,000/year
       Providers:      +$12,000,000/year + SSP bonuses


                Scenario 2 – Volume:
             All Patients Receiving Treatment
       At $5/mo:                   $93,000,000/year
       Providers:     +$18,600,000/year + SSP bonuses

  Calculations based on 5 large provider systems
                           Confidential                  @RxApps
5 ‘Dream’ Customers, ~1.6 Million Users
   Paul Sherman, Med. Dir. at Group Health
       Board President of Seattle Counseling Service, 660k covered lives
   Tom Sequist, CDO at Harvard Vanguard/Atrius
       Researches quality improvement and under-represented
        demographics, 1 M covered lives
   George Isham, Med. Dir. at HealthPartners
       Board of ICSI and NCQA, 1.4 M covered lives
   Martha Wofford, VP at AETNA
       Head of Consumer Platform, 13 M covered lives
   Alfred Fortin, SVP at HMSA
       mHealth Enthusiast, 600k covered lives

                                  Confidential                        @RxApps
Competition
Emerging market, so not much yet. And no one focused on MH


                               Mental        Social     Physician
                Customizable                                        Education
                               Health      Community   Dashboard




                                 ?


    Care Mgmt
    Companies




                                  Confidential                                  @RxApps
The Ask
    Funding: $500k for next 12 months
                Private                        Enterprise     Social
      BU Focus Provider    HIPAA                Partner/    Community
       Group     Trial    Redeploy             Customer      Deployed
  500k                                                                    500k




                                     Build…




          Q2 2012         Q3 2012              Q4 2012          Q1 2013
                                Confidential                              @RxApps
Team
Founders                                               Advisors
       John Moore III, CEO                               Chris Stakutis
           Former genetics scientist                         Patient engagement research at CA
                                                               Tech
           Organizer, Boston Health 2.0
            Chapter                                           Hospital software sales executive at
                                                               Patient Keeper
       ElioMaggini, CTO
                                                          Anne Whitman, PhD
           Multi-startup CTO
                                                              Founder, Cole Resource Center at
           Successful exits to Google and                     McLean Hospital
            Nokia; Visual VM for VZW
                                                              Leading patient advocate
       Christopher McDonald, CFO
                                                          Sarah Lord, PhD
           Back end developer
                                                              Director, Center for Technology and
           Corporate financial analyst, RBS                   Behavioral Health at Dartmouth
       John Moore Jr.                                         Psychiatric Research Institute
           Leading Healthcare IT analyst                 Thor Bergerson, MD
           Idea originator and lead mkt                      Owner, ADHD Boston
            advisor                                           Director, Hallowell Center New York
                                            Confidential                                      @RxApps
Advancing treatment outcomes for
                      chronic illness
“This could help us immensely                                    “Better management of
with our quality payments.”     “If outcomes can be              mental health population?
          -CMO, Pioneer ACO     improved, this is a goldmine.”   Yes, we need that.”
                                      -CEO, Carve-out payer           -VP, Safety-net system


                      Email: john3@PrescribableApps.com
                                Twitter: @RxApps

                                       Confidential                               @RxApps
BACKUPS


          Confidential   @RxApps
Better Treatment


 80% of patients in weekly communication
  with care team had medication changed
within 60 days vs 15% in treatment as usual




             Confidential             @RxApps
Better self-management

“Doctor engagement outside of care
settingincreases adherence by 33%”




               Confidential    @RxApps
Mobile offering adoption by large
providers
             ACO/PCMH Model



                     Now: Time to Act
 Adoption




                   EHR
                                                                       Quality Monitoring
                                                                       Preventive Engagement

            MU    MU Stage 2   Convenience and       ACO Year 1:         ACO expansion; Year 2:
                                   Loyalty         Quality reporting     Quality based payment

                                           Confidential                                           @RxApps
Expansion

                                                                             2017
                                                           Acquisition by:
                                                           -EMR Co.
                                           Solutions for
                                           other Chronic   -Large Payor
                                           Illnesses       -DM Co.
                       Primary Care
                       Implementation
                       (~140,000
                       practicing)
        Psychiatric
        Professional
        Capture
        (22,690
        practicing)

 2012
                                  Confidential                               @RxApps
My Path to PrescribableApps
                        2003
             Vassar: Neuroscience

     Post-undergrad: 2.5 years research at
           MGH, NIBR – not for me

    Post-research: MA2 and RVL Internships

    1st Consulting Project: Health IT Market
            Overview for major VC
                        2011
                    Confidential               @RxApps
Mobile-web enabled




                               6

        6




                Confidential       @RxApps
Summary
    PrescribableApps is a patient-         6
     provider engagement solution
    Patients will better self-manage
     and doctors will provide smarter
     treatment
    Payer systems are starting to
     invest in mobile offerings for
     competitive advantage
     (Aetna, Intermountain, Highmar
     k, etc).
    Very large (>$100 Bn) emerging
     market for accountable care
     organizations

                             Confidential       @RxApps
Vision: Platform for Connected and Continuous Care




                        6




“This could help us immensely                                    “Better management of
with our quality payments.”     “If outcomes can be              mental health population?
          -CMO, Pioneer ACO     improved, this is a goldmine.”   Yes, we need that.”
                                      -CEO, Carve-out payer           -VP, Safety-net system

                                       Confidential                               @RxApps
Patient Engagement Offerings
   Social community for
    sharing experiences

   Badges for continued
    engagement, acknowledg
    ement

   Educational
    resources, interactive
                                        V IDEO
    videos                              S ERIES

                         Confidential             @RxApps
Why this strategy will work:
    4% return users on traditional static
     browsers, 40% return users with mobile web.
    Doctor engagement outside of care setting
     increases adherence by ~33%
    92% of US population owns a cell phone, and
     smartphone saturation is expected in 3 years
    We are developing a prescribablebehavioral
     intervention, which has never been done before
                        Confidential             @RxApps
What we’re looking for now:
    Funding: $500k for next 12 months
        HIPAA compliance
        Integration with first EMR system
        Use cases for customers, strategics
             Trial set up at BU, advisor can get us into rapid testing at
              Dartmouth
    Advisors and Feedback
        Hospital administration connections, warm intros
        Go-to-market validation
        Algorithms/‘big data’ expertise
        Consumer advocate leader (Anne Whitman?)
                                   Confidential                       @RxApps
Market – Mental Health Only                                 Assume cost is
                        Scenario 1 – Focus:                 $4/pt per mo:
                   Only past inpatient/ED history
                     $21 Bn, 6 Million Patients
                                                             60% Margin
      5% Reduction of costs = $166 saved per pt/year         $21.6 M
      5 Large Payers/Providers = 300,000 pts
      At $10/mo:                        $36,000,000/year
      Providers:        $12,000,000/year + SSP bonuses

                     Scenario 2 – Volume:
               All Patients Receiving Treatment
                 $113 Bn, 31 Million Patients
                                                             20% Margin
      2% Reduction of costs = $72 saved per pt/year          $18.6 M
      5 Large Payers/Providers= 1,550,000 pts
      At $5/mo:                          $93,000,000/year
      Providers:        $18,600,000/year + SSP bonuses
                              Confidential                      @RxApps

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12.04.3 7 minute pitch

  • 1. Developing customizable smartphone and web applications for doctorsto personalizepatient engagement in chronic care situations. Confidential @RxApps
  • 2. The Inspiration Mom Confidential @RxApps
  • 3. The pattern – Repeated in College Doctors miss things by no fault of their own Medications do not workby themselves Confidential @RxApps
  • 4. Treatment Follow Up is inconsistent Only 20% make recommended follow up appointments during first 3 months 60% of Patients adherent at 3 months 43% Adherent at 6 months ~50% Overall Adherence Long Term Confidential @RxApps
  • 5. IMAGINE A NEW CARE CONTINUUM… Confidential @RxApps
  • 6. Doctor gives diagnosis and ‘prescription’ to set up account Confidential @RxApps
  • 7. Profile – Set up by Patient Web (S) Confidential @RxApps
  • 8. Use Walkthrough Customize Prompt and Respond View History Confidential @RxApps
  • 9. Built in logic OR 617.555.5656 917.665.7272 911 Irregular, Alarming Normal, Healthy Confidential @RxApps
  • 10. Doctor can monitor in real time and easily reach out; change questions on the fly Confidential @RxApps
  • 11. Provider Dashboard and Registry Patients will eventually be prioritized based on severity of condition at last check in (trending patterns also taken into account) Confidential @RxApps
  • 12. Better Treatment 80% of patients in weekly communication with care team had medication changed within 60 days vs 15% in treatment as usual Treatment Adjustment and Medication Adherence for Complex Patients With Diabetes, Heart Disease, and Depression: A Randomized Controlled Trial Lin, EHB, et al. (2012) Annals of Family Medicine 10:6-14. Confidential @RxApps
  • 13. Better self-management “Doctor engagement outside of care settingincreases adherence by 33%” Confidential @RxApps
  • 14. * * * Over $28 B in savings for MH Alone ImprovedQOL, Management of other Conditions Confidential @RxApps
  • 15. Accountable Care Organizations (ACO) want Monitoring Monitoring Predictive Analytics Simple, Intuitive interfaces Confidential @RxApps
  • 16. HITECH/EMRs ACO/PPACA Tech Reform Mobile Payment Reform Market factors aligned for the first time Prescribable Apps Confidential @RxApps
  • 17. Benefits of Use  Patients  Higher quality of life  Providers and Concierge Care Systems  Competitive advantage  Opportunity for increased revenue  Large Hospital Systems (ACOs, IDNs)  Population management  Shared Savings Program quality reporting Confidential @RxApps
  • 18. Revenue: Per member per month subscription Scenario 1 – Focus: Only past inpatient/ED history At $10/mo: $36,000,000/year Providers: +$12,000,000/year + SSP bonuses Scenario 2 – Volume: All Patients Receiving Treatment At $5/mo: $93,000,000/year Providers: +$18,600,000/year + SSP bonuses Calculations based on 5 large provider systems Confidential @RxApps
  • 19. 5 ‘Dream’ Customers, ~1.6 Million Users  Paul Sherman, Med. Dir. at Group Health  Board President of Seattle Counseling Service, 660k covered lives  Tom Sequist, CDO at Harvard Vanguard/Atrius  Researches quality improvement and under-represented demographics, 1 M covered lives  George Isham, Med. Dir. at HealthPartners  Board of ICSI and NCQA, 1.4 M covered lives  Martha Wofford, VP at AETNA  Head of Consumer Platform, 13 M covered lives  Alfred Fortin, SVP at HMSA  mHealth Enthusiast, 600k covered lives Confidential @RxApps
  • 20. Competition Emerging market, so not much yet. And no one focused on MH Mental Social Physician Customizable Education Health Community Dashboard ? Care Mgmt Companies Confidential @RxApps
  • 21. The Ask  Funding: $500k for next 12 months Private Enterprise Social BU Focus Provider HIPAA Partner/ Community Group Trial Redeploy Customer Deployed 500k 500k Build… Q2 2012 Q3 2012 Q4 2012 Q1 2013 Confidential @RxApps
  • 22. Team Founders Advisors  John Moore III, CEO  Chris Stakutis  Former genetics scientist  Patient engagement research at CA Tech  Organizer, Boston Health 2.0 Chapter  Hospital software sales executive at Patient Keeper  ElioMaggini, CTO  Anne Whitman, PhD  Multi-startup CTO  Founder, Cole Resource Center at  Successful exits to Google and McLean Hospital Nokia; Visual VM for VZW  Leading patient advocate  Christopher McDonald, CFO  Sarah Lord, PhD  Back end developer  Director, Center for Technology and  Corporate financial analyst, RBS Behavioral Health at Dartmouth  John Moore Jr. Psychiatric Research Institute  Leading Healthcare IT analyst  Thor Bergerson, MD  Idea originator and lead mkt  Owner, ADHD Boston advisor  Director, Hallowell Center New York Confidential @RxApps
  • 23. Advancing treatment outcomes for chronic illness “This could help us immensely “Better management of with our quality payments.” “If outcomes can be mental health population? -CMO, Pioneer ACO improved, this is a goldmine.” Yes, we need that.” -CEO, Carve-out payer -VP, Safety-net system Email: john3@PrescribableApps.com Twitter: @RxApps Confidential @RxApps
  • 24. BACKUPS Confidential @RxApps
  • 25. Better Treatment 80% of patients in weekly communication with care team had medication changed within 60 days vs 15% in treatment as usual Confidential @RxApps
  • 26. Better self-management “Doctor engagement outside of care settingincreases adherence by 33%” Confidential @RxApps
  • 27. Mobile offering adoption by large providers ACO/PCMH Model Now: Time to Act Adoption EHR Quality Monitoring Preventive Engagement MU MU Stage 2 Convenience and ACO Year 1: ACO expansion; Year 2: Loyalty Quality reporting Quality based payment Confidential @RxApps
  • 28. Expansion 2017 Acquisition by: -EMR Co. Solutions for other Chronic -Large Payor Illnesses -DM Co. Primary Care Implementation (~140,000 practicing) Psychiatric Professional Capture (22,690 practicing) 2012 Confidential @RxApps
  • 29. My Path to PrescribableApps 2003 Vassar: Neuroscience Post-undergrad: 2.5 years research at MGH, NIBR – not for me Post-research: MA2 and RVL Internships 1st Consulting Project: Health IT Market Overview for major VC 2011 Confidential @RxApps
  • 30. Mobile-web enabled 6 6 Confidential @RxApps
  • 31. Summary  PrescribableApps is a patient- 6 provider engagement solution  Patients will better self-manage and doctors will provide smarter treatment  Payer systems are starting to invest in mobile offerings for competitive advantage (Aetna, Intermountain, Highmar k, etc).  Very large (>$100 Bn) emerging market for accountable care organizations Confidential @RxApps
  • 32. Vision: Platform for Connected and Continuous Care 6 “This could help us immensely “Better management of with our quality payments.” “If outcomes can be mental health population? -CMO, Pioneer ACO improved, this is a goldmine.” Yes, we need that.” -CEO, Carve-out payer -VP, Safety-net system Confidential @RxApps
  • 33. Patient Engagement Offerings  Social community for sharing experiences  Badges for continued engagement, acknowledg ement  Educational resources, interactive V IDEO videos S ERIES Confidential @RxApps
  • 34. Why this strategy will work:  4% return users on traditional static browsers, 40% return users with mobile web.  Doctor engagement outside of care setting increases adherence by ~33%  92% of US population owns a cell phone, and smartphone saturation is expected in 3 years  We are developing a prescribablebehavioral intervention, which has never been done before Confidential @RxApps
  • 35. What we’re looking for now:  Funding: $500k for next 12 months  HIPAA compliance  Integration with first EMR system  Use cases for customers, strategics  Trial set up at BU, advisor can get us into rapid testing at Dartmouth  Advisors and Feedback  Hospital administration connections, warm intros  Go-to-market validation  Algorithms/‘big data’ expertise  Consumer advocate leader (Anne Whitman?) Confidential @RxApps
  • 36. Market – Mental Health Only Assume cost is Scenario 1 – Focus: $4/pt per mo: Only past inpatient/ED history $21 Bn, 6 Million Patients 60% Margin 5% Reduction of costs = $166 saved per pt/year $21.6 M 5 Large Payers/Providers = 300,000 pts At $10/mo: $36,000,000/year Providers: $12,000,000/year + SSP bonuses Scenario 2 – Volume: All Patients Receiving Treatment $113 Bn, 31 Million Patients 20% Margin 2% Reduction of costs = $72 saved per pt/year $18.6 M 5 Large Payers/Providers= 1,550,000 pts At $5/mo: $93,000,000/year Providers: $18,600,000/year + SSP bonuses Confidential @RxApps