8. D.1.2 Outline the experiments of Miller and Urey into the origin of organic compounds Earth’s atmosphere was ‘reducing’ in the early days. It did not contain oxygen gas until after plants started photosynthesising Can you identify these molecules? All molecules public domain from Wikimedia Commons, Background image http://www.flickr.com/photos/lrargerich/4587244190/
9. D.1.2 Outline the experiments of Miller and Urey into the origin of organic compounds Earth’s atmosphere was ‘reducing’ in the early days. It did not contain oxygen gas until after plants started photosynthesising The atmosphere contained: Hydrogen Nitrogen Water vapour Methane Ammonia Hydrogen sulfide The gases came from abundant volcanic activity All molecules public domain from Wikimedia Commons, Background image http://www.flickr.com/photos/lrargerich/4587244190/
10. These monomers mixed in the ‘primeval soup’, shallow oceans laden with chemicals where it is thought that they reacted to form biological molecules Miller and Urey tried to recreate these conditions in the lab in 1953 They were trying to demonstrate ‘chemical evolution’, the formation of more complex molecules from simpler stock in the primeval soup They combined the molecules from the previous page in a closed glass vessel (simulated atmosphere), they heated the water (simulated volcanic activity) and sparked electricity through the gases (simulated lightning) http://www.flickr.com/photos/afeman/663646181/
12. After a week they found: Thirteen of the twenty naturally occurring amino acids Around 15% of the carbon was now in organic compounds
13. D.1.3 State that comets may have delivered organic compounds to Earth Panspermia is the hypothesis that life on Earth originated from material delivered by a comet, either in the form of amino acids or as hardy bacteria Space is so empty, yet full of the potential for life Existing bacteria and archaebacteria have beenfound in odd and extreme environments on Earth: In hot springs, kilometres deep in the crust and even embedded in ice cores from deep inside Antarctica It is feasible that they could survive on or in a comet http://www.flickr.com/photos/12057715@N00/354536849/
14. Cosmic radiation could provide the energy for reactions that lead to the formation of complex organic molecules Analysis of the spectra of light coming from the comets reveals the presence of hydrocarbons, amino acids and peptides The bombardment of Earth by comets 4 billion years ago could have ‘kick started’ chemical evolution http://www.flickr.com/photos/jpstanley/2030855518/
15. D.1.3 Discuss possible locations where conditions could have allowed the synthesis of organic compounds Problem: The water in the Miller Urey experiment tends to hydrolyse any polymers as they form and prevents their formation. The conditions in the ocean not ideal for polymerisation Solution: “black smokers”, hydrothermal vents where superheated steam escapes from within the crust. The outflow is full of dissolved sulfides that crystallise around the vent and may be a suitable environment for the formation and concentration of complex biological compounds http://www.flickr.com/photos/noaaphotolib/5014975047/sizes/l/in/photostream/
16. Volcanoes may also have played a part: Gases from above hot lava lakes have been found to contain a higher than average level of fixed nitrogen Nitrogen fixation is the formation of ammonia (NH4) from nitrogen gas (N2). The Haber process is a modern industrial way to fix nitrogen and it requires high pressures (200 atm) and high temperatures (400 °C) Volcanoes and geysers may have provided a suitable location for the formation of biological compounds The hypothesis that life originated on Earth is called abiogenesis (ab bio genesis) (aboriginal – life – creation) http://www.flickr.com/photos/storm-crypt/3043902298/
17. The hypothesis that life came an extraterrestrial source: As previously mentioned, organic molecules are out there Mars is smaller than Earth and therefore cooled down more quickly, life could have begun there while Earth was still scorching Meteorites and comets impacting on mars could have thrown up debris with early life attached, this could then have crashed on Earth. Meteorites of Mars origin have been found in Antarctica There is no evidence that life has been transferred in this way. Every now and then there is a news story about “Fossils found in Mars meteorite” but so far this has not been confirmed The extraterrestrial hypothesis still doesn’t address how life formed, just how it could move around the galaxy http://images.cdn.fotopedia.com/flickr-2406913018-hd.jpg
18. D.1.5 Outline Two properties of RNA that would have allowed it to play a role in the origin of life RNAs can store, transmit and replicate genetic Information Ribozymes are RNA molecules that can catalyse reactions (Hey! You told us that all enzymes are proteins! Liar!) Some can polymerise nucleotides using ATP Some can break chemical bonds, including peptide bonds Ribosomes are themselves Ribozymes (huh?). The part that catalyses the peptide bonds is RNA, the protein part of a ribosome seems to have a purely structural function Evolution by natural selection requires variation and heritability. RNA possesses these traits http://genetics.mgh.harvard.edu/szostakweb/exploringOriginsDownloads/centralDogma.jpg
19. D.1.6 State that living cells may have been preceded by protobionts, with an internal chemical environment different from their surroundings (Proto = first, or precursor) Coacervatesare droplets of polymeric molecules. Coacervates containing enzyes can absorb and concentrate substrate molecules and then release the products to their surrounds If they absorb a lot of material they can divide into two smaller coacervate droplets This is not true reproduction though so they are not alive. An illustration of a protocell, composed of a fatty acid membrane encapsulating RNA ribozymes. http://exploringorigins.org/protocells.html
23. The first true cells probably heterotrophic (maybe getting energy from sulfur chemistry) and anaerobic (there was no free oxygen) Microspheres:are another candidate for a structure that might have given rise to protobionts. They form when amino acids are heated and polymerise to form simple proteins (thermal proteins) One milligram of thermal proteins can make 100 million microspheres! They divide like coacervates and can catalyse some reactions http://www.daviddarling.info/encyclopedia/M/microsphere.html
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25. The formation of the ozone layer, which blocked out UV and stopped the production of more of the ‘soupy’ moleculesThe oxygen concentration rose to 0.45% of the atmosphere Not much compared to today’s 21%, but it coincides with the rise of the Eukaryotes COINCIDENCE? Probably not.
26. D.1.8 Discuss theendosymbiotictheory for the origin of eukaryotes Evidence in support: Mitochondria and Chloroplasts have their own DNA that is more like bacterial DNA than what is found in the nucleus The structure and biochemistry of chloroplasts is similar to cyanobacteria New organelles are made by a process that resembles binary fission Both organelles have a double membrane which resembles the structure of prokaryotic cells Their ribosomes resemble those of bacteria (70S) DNA analysis suggests that some DNA in plant nuclei was previously in the chloroplast Some proteins coded for in the nucleus are transported to the organelles. The organelles have lost the DNA to make it themselves. Endosymbiosis is the theory that chloroplasts and mitochondria were once free-living prokaryotes that were engulfed by larger prokaryotes and survived to evolve into the modern organelles