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Jean-Paul Grund, PhD 
CVO – Addiction Research Centre, Utrecht 
Department of Addictology, Charles University, Prague 
Harm Reduction & NPS 
Who’s up to the Challenge? 
New drugs, new & 
challenges, new harm reduction? 
EUROHRN @ Amsterdam Thursday 2nd October 16.30 – 17.30
New Psychoactive Substances Homemade drugs The Internet The future 
•New Harms? 
•Harm Reduction 2.0 
Presentation Outline
But it did get easier, way easier.. 
First, a lesson from history
Lifetime use of 'legal highs' in the EU 
15–24 year olds, percentage by country, n > 12000 
“In certain countries some new substances that imitate the effects of illicit drugs are being sold as legal substances in the form of - for example - powders, tablets/pills or herbs. Have you ever used such substances?” 
The Rise of a New Dawn: New Psychoactive Substances (NPS)
Huge growth in number, type and availability 
303 new drugs notified 2005–2013, 67 notified in 2013 so far… 
More than 200 have been notified since 2010 
New NPS in the EU 
2012: 73 
2013: 81
Timeline of NPS
Desomorphine (Permonid™) 
opiate analogue 
Analgesic effect: 10 x morphine 
Toxicity: 3x morphine 
short half-life, 
need for frequent administration 
2/10/14 
Homemade Drugs Cheornaya, Vint, Jeff, Krokodil
This is not Breaking Bad!
Breaking Worse: Bad Chemistry
Breaking Worse: Bad Chemistry hurts 
WARNING! 
GRAPHIC CONTENT!!
2/10/14 
strana 12
Diffusion of drug trends: Heroin in the Netherlands 1972~ 
2/10/14 
strana 13 
Cultural Capital 
Major Port City
Timeline of Cyber Space 
(Just the Surface…) 
jpgrund@compuserve.com 
Internet sales of “Legal Highs”
Homemade Drugs – an Act of Defiance in Eastern Europe 
Tor network 
Bitcoin 
1874 
1980 
1989 
1990 
1999 
2002 
2003 
2008 
2011 
2014 
What happens under the Surface 
Krokodil RU, UK 
USSR ╪ 
Cheornaya 
Vint, Jeff 
PIHKAL 
Heroin 
Krokodil GA 
Krokodil Panic US
Silk Road
Silk road shut down by the DEA (10-2013)
Silk Road 2 
Evolution 
Pandora 
Blue Sky 
Cloud Nine 
Hydra 
Andromeda 
Agora 
Twitter, Instagram 
18 
A glimpse of the future of drug markets?
”There are known knowns; there are things we know we know. We also know there are known unknowns; that is to say we know there are some things we do not know. But there are also unknown unknowns -- the ones we don't know we don't know.” 
Donald Rumsfeld 
New Harms: What do we know?
•Substance related 
•Unknown drugs 
•Unknown Potency – some extremely potent (μg) – Overdose! 
•Set related 
•… … “Legal Highs” & the Unprepared 
•Setting related 
•BBVs? 
•Who is your dealer? 
•Absence of regulation 
New Harms: What do we know?
Where there used to be Grass, Acid, Speed, Brown & Blow…
Where you used to buy from a dealer (a real person), you now buy online or you cook your own…
Harm Reduction 2.0 
A disconnect between drug use 2.0 and harm reduction movement A growing gap between “official” harm reduction and spontaneous, peer driven harm redux P2P HR went online 
•User forums, blogs 
• bluelight.ru; drugs-forum.com; legalhighsforum.com.”
(1) uncovering the substance facts, 
(2) dosage and administration, 
(3) subjectively experienced effects, 
(4) support and safety 
“The main characteristics of the discussions in general were a concern for safety and harm reduction.”
Tor network 
Bitcoin 
1874 
1980 
1989 
1990 
1999 
2002 
2003 
2008 
2011 
2014 
PIHKAL 
Silkroad 
Molecular 3D Printer 
2/10/14 
strana 25 
strana 25 
The Future: Homemade Meets NPS?
Tor network 
Bitcoin 
1874 
1980 
1989 
1990 
1999 
2002 
2003 
2008 
2011 
2014 
PIHKAL 
Silkroad 
Molecular 3D Printer 
2/10/14 
strana 26 
strana 26 
The Future: Homemade Meets NPS? 
LC: “In 5-10 years we will be ordering our medications online, prescription software, personalized to our genetic make up, will be streamed to our 3D printer at home.”
Tor network 
Bitcoin 
1874 
1980 
1989 
1990 
1999 
2002 
2003 
2008 
2011 
2014 
PIHKAL 
Silkroad 
Molecular 3D Printer 
2/10/14 
strana 27 
strana 27 
The Future: Homemade Meets NPS? 
JPG: “Before that, we will be printing our recreational drugs at home. We’ll pay for the software or develop these in online ‘connoisseurs’ clubs.”
Thank you for your attention! 
E: jpgrund@drugresearch.nl 
T: @HeisenbergXL 
W3: drugresearch.nl 
– 
(Most images: Internet. Thanks2Authors!)

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Harm Reduction & New Psychoactive Substances. Who’s up to the Challenge?

  • 1. Jean-Paul Grund, PhD CVO – Addiction Research Centre, Utrecht Department of Addictology, Charles University, Prague Harm Reduction & NPS Who’s up to the Challenge? New drugs, new & challenges, new harm reduction? EUROHRN @ Amsterdam Thursday 2nd October 16.30 – 17.30
  • 2. New Psychoactive Substances Homemade drugs The Internet The future •New Harms? •Harm Reduction 2.0 Presentation Outline
  • 3. But it did get easier, way easier.. First, a lesson from history
  • 4. Lifetime use of 'legal highs' in the EU 15–24 year olds, percentage by country, n > 12000 “In certain countries some new substances that imitate the effects of illicit drugs are being sold as legal substances in the form of - for example - powders, tablets/pills or herbs. Have you ever used such substances?” The Rise of a New Dawn: New Psychoactive Substances (NPS)
  • 5.
  • 6. Huge growth in number, type and availability 303 new drugs notified 2005–2013, 67 notified in 2013 so far… More than 200 have been notified since 2010 New NPS in the EU 2012: 73 2013: 81
  • 8. Desomorphine (Permonid™) opiate analogue Analgesic effect: 10 x morphine Toxicity: 3x morphine short half-life, need for frequent administration 2/10/14 Homemade Drugs Cheornaya, Vint, Jeff, Krokodil
  • 9. This is not Breaking Bad!
  • 10. Breaking Worse: Bad Chemistry
  • 11. Breaking Worse: Bad Chemistry hurts WARNING! GRAPHIC CONTENT!!
  • 13. Diffusion of drug trends: Heroin in the Netherlands 1972~ 2/10/14 strana 13 Cultural Capital Major Port City
  • 14. Timeline of Cyber Space (Just the Surface…) jpgrund@compuserve.com Internet sales of “Legal Highs”
  • 15. Homemade Drugs – an Act of Defiance in Eastern Europe Tor network Bitcoin 1874 1980 1989 1990 1999 2002 2003 2008 2011 2014 What happens under the Surface Krokodil RU, UK USSR ╪ Cheornaya Vint, Jeff PIHKAL Heroin Krokodil GA Krokodil Panic US
  • 17. Silk road shut down by the DEA (10-2013)
  • 18. Silk Road 2 Evolution Pandora Blue Sky Cloud Nine Hydra Andromeda Agora Twitter, Instagram 18 A glimpse of the future of drug markets?
  • 19. ”There are known knowns; there are things we know we know. We also know there are known unknowns; that is to say we know there are some things we do not know. But there are also unknown unknowns -- the ones we don't know we don't know.” Donald Rumsfeld New Harms: What do we know?
  • 20. •Substance related •Unknown drugs •Unknown Potency – some extremely potent (μg) – Overdose! •Set related •… … “Legal Highs” & the Unprepared •Setting related •BBVs? •Who is your dealer? •Absence of regulation New Harms: What do we know?
  • 21. Where there used to be Grass, Acid, Speed, Brown & Blow…
  • 22. Where you used to buy from a dealer (a real person), you now buy online or you cook your own…
  • 23. Harm Reduction 2.0 A disconnect between drug use 2.0 and harm reduction movement A growing gap between “official” harm reduction and spontaneous, peer driven harm redux P2P HR went online •User forums, blogs • bluelight.ru; drugs-forum.com; legalhighsforum.com.”
  • 24. (1) uncovering the substance facts, (2) dosage and administration, (3) subjectively experienced effects, (4) support and safety “The main characteristics of the discussions in general were a concern for safety and harm reduction.”
  • 25. Tor network Bitcoin 1874 1980 1989 1990 1999 2002 2003 2008 2011 2014 PIHKAL Silkroad Molecular 3D Printer 2/10/14 strana 25 strana 25 The Future: Homemade Meets NPS?
  • 26. Tor network Bitcoin 1874 1980 1989 1990 1999 2002 2003 2008 2011 2014 PIHKAL Silkroad Molecular 3D Printer 2/10/14 strana 26 strana 26 The Future: Homemade Meets NPS? LC: “In 5-10 years we will be ordering our medications online, prescription software, personalized to our genetic make up, will be streamed to our 3D printer at home.”
  • 27. Tor network Bitcoin 1874 1980 1989 1990 1999 2002 2003 2008 2011 2014 PIHKAL Silkroad Molecular 3D Printer 2/10/14 strana 27 strana 27 The Future: Homemade Meets NPS? JPG: “Before that, we will be printing our recreational drugs at home. We’ll pay for the software or develop these in online ‘connoisseurs’ clubs.”
  • 28. Thank you for your attention! E: jpgrund@drugresearch.nl T: @HeisenbergXL W3: drugresearch.nl – (Most images: Internet. Thanks2Authors!)