1. Hyphenated Technique of Capillary Electrophoresis and Inductively Coupled Plasma Mass spectrometry Jesús Anzano University of Zaragoza– Department of Analytical Chemistry Zaragoza

6. CE-ICP-MS Instrument Setup Quadrupole Mass Analyzer Detector Computer ICP Interface UV Detector Buffer / Sample Make-up Solution Capillary CE HV Power Supply

7. The CE-ICP-MS Interface Requirements: An electrical connection to the end of CE capillary High aerosol transport efficiency Low dead volume ICP Nebulizer Flow From CE Capillary CE Platinum Ground Electrode Make-up Sheath Flow O-ring

8. The Modified Concentric Nebulizer Nebulizer Gas In CE Capillary Stainless Steel Tube To Spray Chamber CE Capillary Stainless Steel Tube Nebulizer Inner Tube

10. The Direct Injection Interface Nebulizer Gas Platinum Electrode CE Capillary Nebulizer Body ICP Torch Sampler Cone

12. Pulsed Field CE-ICP-MS Instrument Setup V A Sample or Buffer UV Detector Current Voltage Probe Pulse Power Supply Capillary Interface Nebulizer To ICP Capillary with Silver Paint + G

13. Pulsed Field CE-ICP-MS Comparison of power consideration for a continuous versus pulsed CE Continuous  s or ms, Pulsed DC 20kV, 40  A 0.8W Dc: 5kV, 10  A (0.05W) Pulse: 100kV, 0.2mA, 100  s, 200Hz (20W) Average: 0.45W t 1 t 2 Pulse DC

16. Laminar Flow Effect in CE-ICP-MS Cross-Sectional Flow Profile Due to Electroosmotic Flow Cross-Sectional Flow Profile Due to Laminar Flow

18. Preliminary Result The concentric nebulizer and interface

19. The Configuration of Nebulizer Tip Design 1 Design 2 Design 3 Design 4 CE liquid flow Make-up buffer Torr seal

20. Modified Nebulizer Gas Flow Rate Effect

21. 0.0E+00 5.0E+05 1.0E+06 1.5E+06 2.0E+06 2.5E+06 3.0E+06 0.00 0.05 0.10 0.15 0.20 0.25 0.30 0.35 0.40 0.45 0.50 Make-up sheath flow rate (mL/min) 1ppm In signal (acps)/solution flow rate (mL/min) Make-up Sheath Flow Rate Effect