1. PROTEIN 'PASSPORT' HELPS
NANOPARTICLES GET PAST IMMUNE
SYSTEM & PROTEIN “FILMED”
WHILE UNFOLDING AT ATOMIC
RESOLUTION
JUAN ESTEBAN QUIROZ ÁLVAREZ
III SEMESTER OF MEDICINE
TEACHER: LINA MARIA MARTÍNEZ SÁNCHEZ
MOLECULAR BIOLOGY
MARCH 04, 2013

4. STRUCTURAL LEVELS:
-Primary structure:
Amino line.
-Secondary structure:
Alpha and B pleated sheet.
-Tertiary structure:
Alpha and B Togheter.
-Quaternary structure:
Multiple domains.
CHARACTERISTIC:
-Affect the properties that
characterize living organisms.
-Participation in the immune
system.
-Control gene expression.

5. PROTEIN “PASSPORT” HELPS
NANOPARTICLES GET PAST
INMUNE SYSTEM.
Researchers at the
University of
Pennsylvania with
these proteins
discovered how to
prevent the body
from rejecting
medical and
therapeutic
devices.

6. PROTEIN “PASSPORT”HELPS
NANOPARTICLES GET PAST INMUNE
SYSTEM
Protein
“Passport”:
The adaptive immune
system does not work
-Avoid inflammatory in the same way, in
response innate this B and T
immune system, lymphocytes
because this system produces antibodies,
attacks foreign which generates an
bodies in general. improved resistance
to reinfection and
-In this type of
does not attack the
response body in a general
macrophages are way.
involved.

7. PROTEIN “PASSPORT”HELPS
NANOPARTICLES GET PAST INMUNE
SYSTEM.
Macrophages:
-Cellular component in innate
immune response.
-Recognize and destroy the
invaders.
-The proteins bind to the
macrophages… then these
proteins bind to the object in the
blood called macrophages, if they
consider that these proteins have
a foreign invader attack him, for
this is that these “passport”
taunt this recognition to prevent
the therapeutic agent is
degraded.

8. PROTEIN “PASSPORT”HELPS
NANOPARTICLES GET PAST INMUNE
SYSTEM.

9. OBSERVATION

10. PROTEIN “FILMED” WHILE
UNFOLDING AT ATOMIC.
Scientists in Warsaw and elsewhere
have shown in atomic resolution
protein that is losing its shape all with
the goal of showing how and why a
protein loses its three-dimensional
structure.

11. PROTEIN “FILMED” WHILE UNFOLDING AT ATOMIC.
“The scientist's findings may
help to gain deeper insights
into how proteins assume
their spatial structure and
why intermediate forms of
certain proteins misfold in
the event of illness”.

12. PROTEIN “FILMED” WHILE UNFOLDING AT
ATOMIC.

13. PROTEIN “FILMED” WHILE UNFOLDING AT ATOMIC.

14. OBSERVATION
Most importantly, looking ahead in my
opinion is that to know the description of
the structure of the protein on various
factors such as temperature, pH and
others can start making treatments of
neurodegenerative diseases like
Alzheimer's that is today little that can be
done about this.
I also believe that with the development
of know proteins can look at the
molecular processes which can prevent
the folding of proteins in disease.

15. MEDICAL UTILITY
PROTEIN “PASSPORT” HELPS NANOPARTICLES GET PAST
INMUNE SYSTEM.

16. MEDICAL UTILITY
PROTEIN “PASSPORT” HELPS NANOPARTICLES GET PAST
INMUNE SYSTEM.
Creation of
nanoparticles which
may be joined to a wide
range of vehicles for
drug delivery,
utilization of these in
multiple experiments
such as the inhibition
of macrophages. Turn
on the selection of
cancerous cells or
diseased tissues.

17. MEDICAL UTILITY
PROTEIN “FILMED” WHILE UNFOLDING AT ATOMIC.
 With the discovery of the structures
of proteins can perform a treatment
early to prevent these to fold and
form clusters that cause central
nervous system diseases, then this
knowledge can develop and
administer medication to avoid these
folds, this help to reduce global
mortality, as well as this study was
done in bacteria can implement
measures to counter bacterial
infections especially in places that
need greater security against these
pathogens such as hospitals.

18. MEDICAL UTILITY
PROTEIN “FILMED” WHILE UNFOLDING AT ATOMIC.

19. BIBLIOGRAPHY
Martínez Sánchez, Lina Maria; “Biología Molecular”;
7 edition; Upb medical faculty.
 Protein 'Passport' Helps Nanoparticles Get Past
Immune System. Science Daily. Feb.21,2013.
Protein 'Filmed' While Unfolding at Atomic
Resolution. Science Daily. Feb.11,2013.

20. THANK