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January 15, 2011 ◆ Volume 83, Number 2 www.aafp.org/afp American Family Physician 159
Evaluation and Management
of Intestinal Obstruction
PATRICK G. JACKSON, MD, and MANISH RAIJI, MD
Georgetown University Hospital, Washington, District of Columbia
I
ntestinal obstruction accounts for
approximately 15 percent of all emer-
gency department visits for acute
abdominal pain.1
Complications of
intestinal obstruction include bowel isch-
emia and perforation. Morbidity and mor-
tality associated with intestinal obstruction
have declined since the advent of more
sophisticated diagnostic tests, but the condi-
tion remains a challenging surgical diagno-
sis. Physicians who are treating patients with
intestinal obstruction must weigh the risks of
surgery with the consequences of inappropri-
ate conservative management. A suggested
approach to the patient with suspected small
bowel obstruction is shown in Figure 1.
Pathophysiology
The fundamental concerns about intesti-
nal obstruction are its effect on whole body
fluid/electrolyte balances and the mechani-
cal effect that increased pressure has on
intestinal perfusion. Proximal to the point
of obstruction, the intestinal tract dilates as
it fills with intestinal secretions and swal-
lowed air.2
Failure of intestinal contents to
pass through the intestinal tract leads to a
cessation of flatus and bowel movements.
Intestinal obstruction can be broadly dif-
ferentiated into small bowel and large bowel
obstruction.
Fluid loss from emesis, bowel edema, and
loss of absorptive capacity leads to dehydra-
tion. Emesis leads to loss of gastric potassium,
hydrogen, and chloride ions, and signifi-
cant dehydration stimulates renal proximal
tubule reabsorption of bicarbonate and loss
of chloride, perpetuating the metabolic alka-
losis.3
In addition to derangements in fluid
and electrolyte balance, intestinal stasis leads
to overgrowth of intestinal flora, which may
lead to the development of feculent emesis.
Additionally, overgrowth of intestinal flora
in the small bowel leads to bacterial translo-
cation across the bowel wall.4
Ongoing dilation of the intestine increases
luminal pressures. When luminal pressures
exceed venous pressures, loss of venous
drainage causes increasing edema and
hyperemia of the bowel. This may eventu-
ally lead to compromised arterial flow to
the bowel, causing ischemia, necrosis, and
Acute intestinal obstruction occurs when there is an interruption in the forward flow of intes-
tinal contents. This interruption can occur at any point along the length of the gastrointestinal
tract, and clinical symptoms often vary based on the level of obstruction. Intestinal obstruc-
tion is most commonly caused by intra-abdominal adhesions, malignancy, or intestinal hernia-
tion. The clinical presentation generally includes nausea and emesis, colicky abdominal pain,
and a failure to pass flatus or bowel movements. The classic physical examination findings of
abdominal distension, tympany to percussion, and high-pitched bowel sounds suggest the
diagnosis. Radiologic imaging can confirm the diagnosis, and can also serve as useful adjunc-
tive investigations when the diagnosis is less certain. Although radiography is often the initial
study, non-contrast computed tomography is recommended if the index of suspicion is high or
if suspicion persists despite negative radiography. Management of uncomplicated obstructions
includes fluid resuscitation with correction of metabolic derangements, intestinal decompres-
sion, and bowel rest. Evidence of vascular compromise or perforation, or failure to resolve with
adequate bowel decompression is an indication for surgical intervention. (Am Fam Physician.
2011;83(2):159-165. Copyright © 2011 American Academy of Family Physicians.)
▲
Patient information:
A handout on intestinal
obstruction, written by the
authors of this article, is
provided on page 166.
Downloaded from the American Family Physician Web site at www.aafp.org/afp. Copyright © 2011 American Academy of Family Physicians. For the private, noncommer-
cial use of one individual user of the Web site. All other rights reserved. Contact copyrights@aafp.org for copyright questions and/or permission requests.
Intestinal Obstruction
160 American Family Physician www.aafp.org/afp Volume 83, Number 2 ◆ January 15, 2011
perforation. A closed-loop obstruction, in
which a section of bowel is obstructed proxi-
mally and distally, may undergo this pro-
cess rapidly, with few presenting symptoms.
Intestinal volvulus, the prototypical closed-
loop obstruction, causes torsion of arterial
inflow and venous drainage, and is a surgical
emergency.
Causes and Risk Factors
The most common causes of intestinal
obstruction include adhesions, neoplasms,
and herniation (Table 1). Adhesions resulting
from prior abdominal surgery are the pre-
dominant cause of small bowel obstruction,
accounting for approximately 60 percent
of cases.5
Lower abdominal surgeries, includ-
ing appendectomies, colorectal surgery,
gynecologic procedures, and hernia repairs,
confer a greater risk of adhesive small
bowel obstruction. Less common causes of
obstruction include intestinal intussuscep-
tion, volvulus, intra-abdominal abscesses,
gallstones, and foreign bodies.
Management of Small Bowel Obstruction
Figure 1. Algorithm for evaluation and treatment of patients with suspected small bowel
obstruction.
Patient presents with signs and
symptoms of small bowel obstruction
Clinically stable?
No Yes
Radiography or
computed tomography
Vascular compromise
or perforation?
Complete
obstruction
Partial
obstruction
No oral intake,
nasogastric intubation,
intravenous rehydration
Exploratory
laparotomy
No oral intake,
nasogastric intubation,
intravenous rehydration
Yes No
Resolution within 24 to 48 hours? Resolution within 24 to 48 hours?
Yes NoNo Yes
Advance diet
Upper gastrointestinal/
small bowel follow-
through/enteroclysis?
Resolution?
No
Yes
Exploratory
laparotomy
Exploratory
laparotomy
Exploratory
laparotomy
Intestinal Obstruction
January 15, 2011 ◆ Volume 83, Number 2 www.aafp.org/afp American Family Physician 161
History and Physical Examination
Patients should be asked about their history
of abdominal neoplasia, hernia or hernia
repair, and inflammatory bowel disease,
because these conditions increase the risk
of obstruction. The hallmarks of intesti-
nal obstruction include colicky abdominal
pain, nausea and vomiting, abdominal dis-
tension, and a cessation of flatus and bowel
movements. It is important to differentiate
between true mechanical obstruction and
other causes of these symptoms (Table 2).
Distal obstructions allow for a greater intes-
tinal reservoir, with pain and distension
more marked than emesis, whereas patients
with proximal obstructions may have mini-
mal abdominal distension but marked
emesis. The presence of hypotension and
tachycardia is an indication of severe dehy-
dration. Abdominal palpation may reveal a
distended, tympanitic abdomen; however,
this finding may not be present in patients
with early or proximal obstruction. Aus-
cultation in patients with early obstruction
reveals high-pitched bowel sounds, whereas
those with late obstruction may present with
minimal bowel sounds as the intestinal tract
becomes hypotonic.
Diagnostic Testing and Imaging
LABORATORY TESTS
Laboratory evaluation of patients with sus-
pected obstruction should include a com-
plete blood count and metabolic panel.
Hypokalemic, hypochloremic metabolic
alkalosis may be noted in patients with
severe emesis. Elevated blood urea nitrogen
levels are consistent with dehydration, and
hemoglobin and hematocrit levels may be
increased. The white blood cell count may
be elevated if intestinal bacteria translocate
into the bloodstream, causing the systemic
inflammatory response syndrome or sepsis.
The development of metabolic acidosis, espe-
cially in a patient with an increasing serum
lactate level, may signal bowel ischemia.
RADIOGRAPHY
The initial evaluation of patients with
clinical signs and symptoms of intestinal
obstruction should include plain upright
abdominal radiography. Radiography can
quickly determine if intestinal perforation
has occurred; free air can be seen above the
liver in upright films or left lateral decubi-
tus films. Radiography accurately diagno-
ses intestinal obstruction in approximately
60 percent of cases,6
and its positive predic-
tive value approaches 80 percent in patients
with high-grade intestinal obstruction.7
However, plain abdominal films can appear
normal in early obstruction and in high
jejunal or duodenal obstruction. Therefore,
when clinical suspicion for obstruction is
high or persists despite negative initial radi-
ography, non-contrast computed tomogra-
phy (CT) should be ordered.8
In patients with small bowel obstruc-
tion, supine views show dilation of multiple
loops of small bowel, with a paucity of air in
the large bowel (Figure 2). Those with large
bowel obstruction may have dilation of the
Table 1. Causes of Intestinal
Obstruction
Adhesive disease (60 percent)
Neoplasm (20 percent)
Herniation (10 percent)
Inflammatory bowel disease (5 percent)
Intussusception (< 5 percent)
Volvulus (< 5 percent)
Other (< 5 percent)
Table 2. Differential Diagnosis of Abdominal Pain,
Distension, Nausea, and Cessation of Flatus and
Bowel Movements
Alternate diagnosis Clues
Ascites Acute liver failure, history of hepatitis or
alcoholism
Medications (e.g., tricyclic
antidepressants, narcotics)
Review of medications; diagnosis of
exclusion
Mesenteric ischemia History of peripheral vascular disease,
hypercoagulable state, or postprandial
abdominal angina; recent use of
vasopressors
Perforated viscus/intra-
abdominal sepsis
Fever, leukocytosis, acute abdomen, free
air on imaging
Postoperative paralytic ileus Recent abdominal surgery with no
postoperative flatus or bowel movement
Pseudo-obstruction
(Ogilvie syndrome)
Acutely dilated large intestine, history of
intestinal dysmotility, diabetes mellitus,
scleroderma
Intestinal Obstruction
162 American Family Physician www.aafp.org/afp Volume 83, Number 2 ◆ January 15, 2011
colon, with decompressed small bowel in the
setting of a competent ileocecal valve. Upright
or lateral decubitus films may show laddering
air fluid levels (Figure 3). These findings, in
conjunction with a lack of air and stool in the
distal colon and rectum, are highly suggestive
of mechanical intestinal obstruction.
COMPUTED TOMOGRAPHY
CT is appropriate for further evaluation of
patients with suspected intestinal obstruc-
tion in whom clinical examination and radi-
ography do not yield a definitive diagnosis.
CT is sensitive for detection of high-grade
obstruction (up to 90 percent in some series),9
and has the additional benefit of defining
the cause and level of obstruction in most
patients.10-12
In addition, CT can identify
emergent causes of intestinal obstruction,
such as volvulus or intestinal strangulation.
CT findings in patients with intestinal
obstruction include dilated loops of bowel
proximal to the site of obstruction, with dis-
tally decompressed bowel. The presence of a
discrete transition point helps guide opera-
tive planning (Figure 4). Absence of contrast
material in the rectum is also an impor-
tant sign of complete obstruction. For this
Figure 3. Lateral decubitus view of the abdomen, showing air-fluid
levels consistent with intestinal obstruction (arrows).
Figure 2. Supine view of the abdomen in a patient with intestinal
obstruction. Dilated loops of small bowel are visible (arrows).
Figure 4. Axial computed tomography scan
showing dilated, contrast-filled loops of
bowel on the patient’s left (yellow arrows),
with decompressed distal small bowel on
the patient’s right (red arrows). The cause of
obstruction, an incarcerated umbilical hernia,
can also be seen (green arrow), with proxi-
mally dilated bowel entering the hernia and
decompressed bowel exiting the hernia.
The rights holder did not grant the American Academy of Family
Physicians the right to sublicense this material to a third party. For
the missing item, see the original print version of this publication.
The rights holder did not grant the American Academy of Family
Physicians the right to sublicense this material to a third party. For
the missing item, see the original print version of this publication.
The rights holder did not grant the Ameri-
can Academy of Family Physicians the
right to sublicense this material to a third
party. For the missing item, see the origi-
nal print version of this publication.
Intestinal Obstruction
January 15, 2011 ◆ Volume 83, Number 2 www.aafp.org/afp American Family Physician 163
reason, rectal administration of contrast
material should be avoided. A C-loop of dis-
tended bowel with radial mesenteric vessels
with medial conversion is highly suspicious
for intestinal volvulus. Thickened intesti-
nal walls and poor flow of contrast material
into a section of bowel suggests ischemia,
whereas pneumatosis intestinalis, free intra-
peritoneal air, and mesenteric fat stranding
suggest necrosis and perforation.
Although CT is highly sensitive and spe-
cific for high-grade obstruction, its value
diminishes in patients with partial obstruc-
tion. In these patients, oral contrast mate-
rial may be seen traversing the length of the
intestine to the rectum, with no discrete area
of transition. Fluoroscopy may be of greater
value in confirming the diagnosis.
The American College of Radiology rec-
ommends non-contrast CT as the initial
imaging modality of choice.13
However,
because most causes of small bowel obstruc-
tion will have systemic manifestations or fail
to resolve—necessitating operative interven-
tion—the additional diagnostic value of CT
compared with radiography is limited. Radi-
ation exposure is also significant. Therefore,
in most patients, CT should be ordered when
the diagnosis is in doubt, when there is no
surgical history or hernias to explain the eti-
ology, or when there is a high index of suspi-
cion for complete or high-grade obstruction.
CONTRAST FLUOROSCOPY
Contrast studies, such as a small bowel
follow-through, can be helpful in the diag-
nosis of a partial intestinal obstruction in
patients with high clinical suspicion and in
clinically stable patients in whom initial con-
servative management was not effective.14
The use of water-soluble contrast material is
not only diagnostic, but may also be thera-
peutic in patients with partial small-bowel
obstruction. A randomized controlled trial
of 124 patients showed a 74 percent reduc-
tion in the need for surgical intervention in
patients receiving gastrografin fluoroscopy
within 24 hours of initial presentation.15
Contrast fluoroscopy may also be useful in
determining the need for surgery; the pres-
ence of contrast material in the rectum
within 24 hours of administration has a
97 percent sensitivity for spontaneous resolu-
tion of intestinal obstruction.16,17
There are several variations of contrast
fluoroscopy. In the small-bowel follow-
through study, the patient drinks contrast
material, then serial abdominal radiographs
are taken to visualize the passage of contrast
through the intestinal tract. Enteroclysis
involves naso- or oro-duodenal intubation,
followed by the instillation of contrast mate-
rial directly into the small bowel. Although
this study has superior sensitivity compared
with small-bowel follow-through,18
it is more
labor-intensive and is rarely performed.
Rectal fluoroscopy can be helpful in deter-
mining the site of a suspected large bowel
obstruction.
ULTRASONOGRAPHY
In patients with high-grade obstruction,
ultrasound evaluation of the abdomen has
high sensitivity for intestinal obstruction,
approaching 85 percent.19
However, because
of the wide availability of CT, it has largely
replaced ultrasonography as the first-line
investigation in stable patients with suspected
intestinal obstruction. Ultrasonography
remains a valuable investigation for unstable
patients with an ambiguous diagnosis and in
patients for whom radiation exposure is con-
traindicated, such as pregnant women.
MAGNETIC RESONANCE IMAGING
Magnetic resonance imaging (MRI) may be
more sensitive than CT in the evaluation of
intestinal obstruction.20
MRI enteroclysis,
which involves intubation of the duodenum
and infusion of contrast material directly
into the small bowel, can more reliably
determine the location and cause of obstruc-
tion.21
However, because of the ease and cost-
effectiveness of abdominal CT, MRI remains
an investigational or adjunctive imaging
modality for intestinal obstruction.
Treatment
Management of intestinal obstruction is
directed at correcting physiologic derange-
ments caused by the obstruction, bowel rest,
and removing the source of obstruction. The
Intestinal Obstruction
164 American Family Physician www.aafp.org/afp Volume 83, Number 2 ◆ January 15, 2011
former is addressed by intravenous fluid
resuscitation with isotonic fluid. The use of
a bladder catheter to closely monitor urine
output is the minimum requirement for
gauging the adequacy of resuscitation; other
invasive measures, such as arterial canaliza-
tion or central venous pressure monitoring,
can be used as the clinical situation war-
rants. Antibiotics are used to treat intestinal
overgrowth of bacteria and translocation
across the bowel wall.22
The presence of fever
and leukocytosis should prompt inclusion of
antibiotics in the initial treatment regimen.
Antibiotics should have coverage against
gram-negative organisms and anaerobes,
and the choice of a specific agent should be
determined by local susceptibility and avail-
ability. Aggressive replacement of electro-
lytes is recommended after adequate renal
function is confirmed.
The decision to perform surgery for intes-
tinal obstruction can be difficult. Perito-
nitis, clinical instability, or unexplained
leukocytosis or acidosis are concerning for
abdominal sepsis, intestinal ischemia, or
perforation; these findings mandate imme-
diate surgical exploration. Patients with an
obstruction that resolves after reduction of
a hernia should be scheduled for elective
hernia repair, whereas immediate surgery
is required in patients with an irreducible
or strangulated hernia. Stable patients with
a history of abdominal malignancy or high
suspicion for malignancy should be thor-
oughly evaluated for optimal surgical plan-
ning. Abdominal malignancy can be treated
with primary resection and reconstruction
or palliative diversion, or placement of vent-
ing and feeding tubes.
Treatment of stable patients with intesti-
nal obstruction and a history of abdominal
surgery presents a challenge. Conservative
management of a high-grade obstruction
should be attempted initially, using intesti-
nal intubation and decompression, aggres-
sive intravenous rehydration, and antibiotics.
The inclusion of oral magnesium hydroxide,
simethicone, and probiotics decreased the
length of hospitalization in a randomized
controlled trial of 144 patients with partial
small bowel obstructions (number needed
to treat = 7).23
Caution should be used when
clinical and radiologic evidence suggest com-
pleteobstruction,becausetheuseofintestinal
stimulation can exacerbate the obstruction
and precipitate intestinal ischemia.
SORT: KEY RECOMMENDATIONS FOR PRACTICE
Clinical recommendation
Evidence
rating References Comments
Abdominal radiography is an effective initial
examination in patients with suspected intestinal
obstruction.
C 6, 7 Radiography has greater sensitivity in
high-grade obstruction than in partial
obstruction.
Computed tomography is warranted when
radiography indicates high-grade intestinal
obstruction or is inconclusive.
C 8-10 Computed tomography can reliably determine
the cause of obstruction, and whether
serious complications are present, in most
patients with high-grade obstructions.
Upper gastrointestinal fluoroscopy with small
bowel follow-through can determine the need
for surgical intervention in patients with partial
obstruction.
C 14, 15 Contrast material that passes into the cecum
within four hours of oral administration is
highly predictive of successful nonoperative
management.
Antibiotics can protect against bacterial
translocation and subsequent bacteremia in
patients with intestinal obstruction.
C 22 Enteric bacteria have been found in cultures
from serosal scrapings and mesenteric lymph
node biopsy in patients requiring surgery.
Clinically stable patients can be treated
conservatively with bowel rest, intubation
and decompression, and intravenous fluid
resuscitation.
A 22-26 Several randomized controlled trials have
shown that surgery can be avoided with
conservative management.
Surgery is warranted in patients with intestinal
obstruction that does not resolve within 48 hours
after conservative therapy is initiated.
B 25 Study found that conservative management
beyond 48 hours does not diminish the need
for surgery, but increases surgical morbidity.
A = consistent, good-quality patient-oriented evidence; B = inconsistent or limited-quality patient-oriented evidence; C = consensus, disease-
oriented evidence, usual practice, expert opinion, or case series. For information about the SORT evidence rating system, go to http://www.aafp.
org/afpsort.xml.
Intestinal Obstruction
January 15, 2011 ◆ Volume 83, Number 2 www.aafp.org/afp American Family Physician 165
Conservative management is successful in
40 to 70 percent of clinically stable patients,
with a higher success rate in those with partial
obstruction.24-26
Although conservative man-
agement is associated with shorter initial hos-
pitalization (4.9 versus 12 days), there is also a
higher rate of eventual recurrence (40.5 versus
26.8 percent).27
With conservative manage-
ment, resolution generally occurs within 24
to 48 hours. Beyond this time frame, the risk
of complications, including vascular compro-
mise, increases. If intestinal obstruction is not
resolved with conservative management, sur-
gical evaluation is required.25
Figures 2 through 4 provided by Cirrelda J. Cooper, MD.
The Authors
PATRICK G. JACKSON, MD, is chief of gastrointestinal sur-
gery at Georgetown University Hospital, Washington, DC.
MANISH RAIJI, MD, is a third year surgical resident at
Georgetown University Hospital.
Address correspondence to Patrick G. Jackson, MD, 3800
Reservoir Rd., 4th Floor, PHC, Washington, DC 20007.
Reprints are not available from the authors.
Author disclosure: Nothing to disclose.
REFERENCES
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2. Wright HK, O’Brien JJ, Tilson MD. Water absorption in
experimental closed segment obstruction of the ileum
in man. Am J Surg. 1971;121(1):96-99.
3. Wangensteen OH. Understanding the bowel obstruc-
tion problem. Am J Surg. 1978;135(2):131-149.
4. Rana SV, Bhardwaj SB. Small intestinal bacterial over-
growth. Scand J Gastroenterol. 2008;43(9):1030-1037.
5. Shelton BK. Intestinal obstruction [published correction
appears in AACN Clin Issues. 2000;11(1):following table
of contents]. AACN Clin Issues. 1999;10(4):478-491.
6. Maglinte DD, Heitkamp DE, Howard TJ, Kelvin FM, Lap-
pas JC. Current concepts in imaging of small bowel
obstruction. Radiol Clin North Am. 2003;41(2):263-283.
7. Lappas JC, Reyes BL, Maglinte DD. Abdominal radiog-
raphy findings in small-bowel obstruction: relevance
to triage for additional diagnostic imaging. AJR Am
J Roentgenol. 2001;176(1):167-174.
8. Stoker J, van Randen A, Laméris W, Boermeester MA.
Imaging patients with acute abdominal pain. Radiology.
2009;253(1):31-46.
9. Suri S, Gupta S, Sudhakar PJ, Venkataramu NK, Sood B,
Wig JD. Comparative evaluation of plain films, ultra-
sound and CT in the diagnosis of intestinal obstruction.
Acta Radiol. 1999;40(4):422-428.
10. Furukawa A, Yamasaki M, Furuichi K, et al. Helical CT in
the diagnosis of small bowel obstruction. Radiographics.
2001;21(2):341-355.
11. Gazelle GS, Goldberg MA, Wittenberg J, Halpern EF,
Pinkney L, Mueller PR. Efficacy of CT in distinguishing
small-bowel obstruction from other causes of small-bowel
dilatation. AJR Am J Roentgenol. 1994;162(1):43-47.
12. Frager DH, Baer JW, Rothpearl A, Bossart PA. Distinc-
tion between postoperative ileus and mechanical small-
bowel obstruction: value of CT compared with clinical
and other radiographic findings. AJR Am J Roentgenol.
1995;164(4):891-894.
13. Ros PR, Huprich JE. ACR Appropriateness Criteria on
suspected small-bowel obstruction. J Am Coll Radiol.
2006;3(11):838-841.
14. Hayanga AJ, Bass-Wilkins K, Bulkley GB. Current man-
agement of small-bowel obstruction. Adv Surg. 2005;
39:1-33.
15. Choi HK, Chu KW, Law WL. Therapeutic value of gas-
trografin in adhesive small bowel obstruction after
unsuccessful conservative treatment: a prospective ran-
domized trial. Ann Surg. 2002;236(1):1-6.
16. Abbas S, Bissett IP, Parry BR. Oral water soluble contrast
for the management of adhesive small bowel obstruc-
tion. Cochrane Database Syst Rev. 2007;(3):CD004651.
17. Anderson CA, Humphrey WT. Contrast radiography
in small bowel obstruction: a prospective, randomized
trial. Mil Med. 1997;162(11):749-752.
18. Dunn JT, Halls JM, Berne TV. Roentgenographic con-
trast studies in acute small-bowel obstruction. Arch
Surg. 1984;119(11):1305-1308.
19. Lim JH, Ko YT, Lee DH, Lee HW, Lim JW. Determining
the site and causes of colonic obstruction with sonog-
raphy. AJR Am J Roentgenol. 1994;163(5):1113-1117.
20. Matsuoka H, Takahara T, Masaki T, Sugiyama M,
Hachiya J, Atomi Y. Preoperative evaluation by magnetic
resonance imaging in patients with bowel obstruction.
Am J Surg. 2002;183(6):614-617.
21. Wiarda BM, Horsthuis K, Dobben AC, et al. Magnetic
resonance imaging of the small bowel with the true
FISP sequence: intra- and interobserver agreement of
enteroclysis and imaging without contrast material. Clin
Imaging. 2009;33(4):267-273.
22. Sagar PM, MacFie J, Sedman P, May J, Mancey-Jones B,
Johnstone D. Intestinal obstruction promotes gut trans-
location of bacteria. Dis Colon Rectum. 1995;38(6):
640-644.
23. Chen SC, Yen ZS, Lee CC, et al. Nonsurgical manage-
ment of partial adhesive small-bowel obstruction with
oral therapy: a randomized controlled trial. CMAJ.
2005;173(10):1165-1169.
24. Mosley JG, Shoaib A. Operative versus conservative man-
agement of adhesional intestinal obstruction. Br J Surg.
2000;87(3):362-373.
25. Fevang BT, Jensen D, Svanes K, Viste A. Early opera-
tion or conservative management of patients with small
bowel obstruction? Eur J Surg. 2002;168(8-9):475-481.
26. Williams SB, Greenspon J, Young HA, Orkin BA. Small
bowel obstruction: conservative vs. surgical manage-
ment. Dis Colon Rectum. 2005;48(6):1140-1146.
27. Cox MR, Gunn IF, Eastman MC, Hunt RF, Heinz AW.
The safety and duration of non-operative treatment
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1993;63(5):367-371.

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Evaluation and management of intestinal obstruction

  • 1. January 15, 2011 ◆ Volume 83, Number 2 www.aafp.org/afp American Family Physician 159 Evaluation and Management of Intestinal Obstruction PATRICK G. JACKSON, MD, and MANISH RAIJI, MD Georgetown University Hospital, Washington, District of Columbia I ntestinal obstruction accounts for approximately 15 percent of all emer- gency department visits for acute abdominal pain.1 Complications of intestinal obstruction include bowel isch- emia and perforation. Morbidity and mor- tality associated with intestinal obstruction have declined since the advent of more sophisticated diagnostic tests, but the condi- tion remains a challenging surgical diagno- sis. Physicians who are treating patients with intestinal obstruction must weigh the risks of surgery with the consequences of inappropri- ate conservative management. A suggested approach to the patient with suspected small bowel obstruction is shown in Figure 1. Pathophysiology The fundamental concerns about intesti- nal obstruction are its effect on whole body fluid/electrolyte balances and the mechani- cal effect that increased pressure has on intestinal perfusion. Proximal to the point of obstruction, the intestinal tract dilates as it fills with intestinal secretions and swal- lowed air.2 Failure of intestinal contents to pass through the intestinal tract leads to a cessation of flatus and bowel movements. Intestinal obstruction can be broadly dif- ferentiated into small bowel and large bowel obstruction. Fluid loss from emesis, bowel edema, and loss of absorptive capacity leads to dehydra- tion. Emesis leads to loss of gastric potassium, hydrogen, and chloride ions, and signifi- cant dehydration stimulates renal proximal tubule reabsorption of bicarbonate and loss of chloride, perpetuating the metabolic alka- losis.3 In addition to derangements in fluid and electrolyte balance, intestinal stasis leads to overgrowth of intestinal flora, which may lead to the development of feculent emesis. Additionally, overgrowth of intestinal flora in the small bowel leads to bacterial translo- cation across the bowel wall.4 Ongoing dilation of the intestine increases luminal pressures. When luminal pressures exceed venous pressures, loss of venous drainage causes increasing edema and hyperemia of the bowel. This may eventu- ally lead to compromised arterial flow to the bowel, causing ischemia, necrosis, and Acute intestinal obstruction occurs when there is an interruption in the forward flow of intes- tinal contents. This interruption can occur at any point along the length of the gastrointestinal tract, and clinical symptoms often vary based on the level of obstruction. Intestinal obstruc- tion is most commonly caused by intra-abdominal adhesions, malignancy, or intestinal hernia- tion. The clinical presentation generally includes nausea and emesis, colicky abdominal pain, and a failure to pass flatus or bowel movements. The classic physical examination findings of abdominal distension, tympany to percussion, and high-pitched bowel sounds suggest the diagnosis. Radiologic imaging can confirm the diagnosis, and can also serve as useful adjunc- tive investigations when the diagnosis is less certain. Although radiography is often the initial study, non-contrast computed tomography is recommended if the index of suspicion is high or if suspicion persists despite negative radiography. Management of uncomplicated obstructions includes fluid resuscitation with correction of metabolic derangements, intestinal decompres- sion, and bowel rest. Evidence of vascular compromise or perforation, or failure to resolve with adequate bowel decompression is an indication for surgical intervention. (Am Fam Physician. 2011;83(2):159-165. Copyright © 2011 American Academy of Family Physicians.) ▲ Patient information: A handout on intestinal obstruction, written by the authors of this article, is provided on page 166. Downloaded from the American Family Physician Web site at www.aafp.org/afp. Copyright © 2011 American Academy of Family Physicians. For the private, noncommer- cial use of one individual user of the Web site. All other rights reserved. Contact copyrights@aafp.org for copyright questions and/or permission requests.
  • 2. Intestinal Obstruction 160 American Family Physician www.aafp.org/afp Volume 83, Number 2 ◆ January 15, 2011 perforation. A closed-loop obstruction, in which a section of bowel is obstructed proxi- mally and distally, may undergo this pro- cess rapidly, with few presenting symptoms. Intestinal volvulus, the prototypical closed- loop obstruction, causes torsion of arterial inflow and venous drainage, and is a surgical emergency. Causes and Risk Factors The most common causes of intestinal obstruction include adhesions, neoplasms, and herniation (Table 1). Adhesions resulting from prior abdominal surgery are the pre- dominant cause of small bowel obstruction, accounting for approximately 60 percent of cases.5 Lower abdominal surgeries, includ- ing appendectomies, colorectal surgery, gynecologic procedures, and hernia repairs, confer a greater risk of adhesive small bowel obstruction. Less common causes of obstruction include intestinal intussuscep- tion, volvulus, intra-abdominal abscesses, gallstones, and foreign bodies. Management of Small Bowel Obstruction Figure 1. Algorithm for evaluation and treatment of patients with suspected small bowel obstruction. Patient presents with signs and symptoms of small bowel obstruction Clinically stable? No Yes Radiography or computed tomography Vascular compromise or perforation? Complete obstruction Partial obstruction No oral intake, nasogastric intubation, intravenous rehydration Exploratory laparotomy No oral intake, nasogastric intubation, intravenous rehydration Yes No Resolution within 24 to 48 hours? Resolution within 24 to 48 hours? Yes NoNo Yes Advance diet Upper gastrointestinal/ small bowel follow- through/enteroclysis? Resolution? No Yes Exploratory laparotomy Exploratory laparotomy Exploratory laparotomy
  • 3. Intestinal Obstruction January 15, 2011 ◆ Volume 83, Number 2 www.aafp.org/afp American Family Physician 161 History and Physical Examination Patients should be asked about their history of abdominal neoplasia, hernia or hernia repair, and inflammatory bowel disease, because these conditions increase the risk of obstruction. The hallmarks of intesti- nal obstruction include colicky abdominal pain, nausea and vomiting, abdominal dis- tension, and a cessation of flatus and bowel movements. It is important to differentiate between true mechanical obstruction and other causes of these symptoms (Table 2). Distal obstructions allow for a greater intes- tinal reservoir, with pain and distension more marked than emesis, whereas patients with proximal obstructions may have mini- mal abdominal distension but marked emesis. The presence of hypotension and tachycardia is an indication of severe dehy- dration. Abdominal palpation may reveal a distended, tympanitic abdomen; however, this finding may not be present in patients with early or proximal obstruction. Aus- cultation in patients with early obstruction reveals high-pitched bowel sounds, whereas those with late obstruction may present with minimal bowel sounds as the intestinal tract becomes hypotonic. Diagnostic Testing and Imaging LABORATORY TESTS Laboratory evaluation of patients with sus- pected obstruction should include a com- plete blood count and metabolic panel. Hypokalemic, hypochloremic metabolic alkalosis may be noted in patients with severe emesis. Elevated blood urea nitrogen levels are consistent with dehydration, and hemoglobin and hematocrit levels may be increased. The white blood cell count may be elevated if intestinal bacteria translocate into the bloodstream, causing the systemic inflammatory response syndrome or sepsis. The development of metabolic acidosis, espe- cially in a patient with an increasing serum lactate level, may signal bowel ischemia. RADIOGRAPHY The initial evaluation of patients with clinical signs and symptoms of intestinal obstruction should include plain upright abdominal radiography. Radiography can quickly determine if intestinal perforation has occurred; free air can be seen above the liver in upright films or left lateral decubi- tus films. Radiography accurately diagno- ses intestinal obstruction in approximately 60 percent of cases,6 and its positive predic- tive value approaches 80 percent in patients with high-grade intestinal obstruction.7 However, plain abdominal films can appear normal in early obstruction and in high jejunal or duodenal obstruction. Therefore, when clinical suspicion for obstruction is high or persists despite negative initial radi- ography, non-contrast computed tomogra- phy (CT) should be ordered.8 In patients with small bowel obstruc- tion, supine views show dilation of multiple loops of small bowel, with a paucity of air in the large bowel (Figure 2). Those with large bowel obstruction may have dilation of the Table 1. Causes of Intestinal Obstruction Adhesive disease (60 percent) Neoplasm (20 percent) Herniation (10 percent) Inflammatory bowel disease (5 percent) Intussusception (< 5 percent) Volvulus (< 5 percent) Other (< 5 percent) Table 2. Differential Diagnosis of Abdominal Pain, Distension, Nausea, and Cessation of Flatus and Bowel Movements Alternate diagnosis Clues Ascites Acute liver failure, history of hepatitis or alcoholism Medications (e.g., tricyclic antidepressants, narcotics) Review of medications; diagnosis of exclusion Mesenteric ischemia History of peripheral vascular disease, hypercoagulable state, or postprandial abdominal angina; recent use of vasopressors Perforated viscus/intra- abdominal sepsis Fever, leukocytosis, acute abdomen, free air on imaging Postoperative paralytic ileus Recent abdominal surgery with no postoperative flatus or bowel movement Pseudo-obstruction (Ogilvie syndrome) Acutely dilated large intestine, history of intestinal dysmotility, diabetes mellitus, scleroderma
  • 4. Intestinal Obstruction 162 American Family Physician www.aafp.org/afp Volume 83, Number 2 ◆ January 15, 2011 colon, with decompressed small bowel in the setting of a competent ileocecal valve. Upright or lateral decubitus films may show laddering air fluid levels (Figure 3). These findings, in conjunction with a lack of air and stool in the distal colon and rectum, are highly suggestive of mechanical intestinal obstruction. COMPUTED TOMOGRAPHY CT is appropriate for further evaluation of patients with suspected intestinal obstruc- tion in whom clinical examination and radi- ography do not yield a definitive diagnosis. CT is sensitive for detection of high-grade obstruction (up to 90 percent in some series),9 and has the additional benefit of defining the cause and level of obstruction in most patients.10-12 In addition, CT can identify emergent causes of intestinal obstruction, such as volvulus or intestinal strangulation. CT findings in patients with intestinal obstruction include dilated loops of bowel proximal to the site of obstruction, with dis- tally decompressed bowel. The presence of a discrete transition point helps guide opera- tive planning (Figure 4). Absence of contrast material in the rectum is also an impor- tant sign of complete obstruction. For this Figure 3. Lateral decubitus view of the abdomen, showing air-fluid levels consistent with intestinal obstruction (arrows). Figure 2. Supine view of the abdomen in a patient with intestinal obstruction. Dilated loops of small bowel are visible (arrows). Figure 4. Axial computed tomography scan showing dilated, contrast-filled loops of bowel on the patient’s left (yellow arrows), with decompressed distal small bowel on the patient’s right (red arrows). The cause of obstruction, an incarcerated umbilical hernia, can also be seen (green arrow), with proxi- mally dilated bowel entering the hernia and decompressed bowel exiting the hernia. The rights holder did not grant the American Academy of Family Physicians the right to sublicense this material to a third party. For the missing item, see the original print version of this publication. The rights holder did not grant the American Academy of Family Physicians the right to sublicense this material to a third party. For the missing item, see the original print version of this publication. The rights holder did not grant the Ameri- can Academy of Family Physicians the right to sublicense this material to a third party. For the missing item, see the origi- nal print version of this publication.
  • 5. Intestinal Obstruction January 15, 2011 ◆ Volume 83, Number 2 www.aafp.org/afp American Family Physician 163 reason, rectal administration of contrast material should be avoided. A C-loop of dis- tended bowel with radial mesenteric vessels with medial conversion is highly suspicious for intestinal volvulus. Thickened intesti- nal walls and poor flow of contrast material into a section of bowel suggests ischemia, whereas pneumatosis intestinalis, free intra- peritoneal air, and mesenteric fat stranding suggest necrosis and perforation. Although CT is highly sensitive and spe- cific for high-grade obstruction, its value diminishes in patients with partial obstruc- tion. In these patients, oral contrast mate- rial may be seen traversing the length of the intestine to the rectum, with no discrete area of transition. Fluoroscopy may be of greater value in confirming the diagnosis. The American College of Radiology rec- ommends non-contrast CT as the initial imaging modality of choice.13 However, because most causes of small bowel obstruc- tion will have systemic manifestations or fail to resolve—necessitating operative interven- tion—the additional diagnostic value of CT compared with radiography is limited. Radi- ation exposure is also significant. Therefore, in most patients, CT should be ordered when the diagnosis is in doubt, when there is no surgical history or hernias to explain the eti- ology, or when there is a high index of suspi- cion for complete or high-grade obstruction. CONTRAST FLUOROSCOPY Contrast studies, such as a small bowel follow-through, can be helpful in the diag- nosis of a partial intestinal obstruction in patients with high clinical suspicion and in clinically stable patients in whom initial con- servative management was not effective.14 The use of water-soluble contrast material is not only diagnostic, but may also be thera- peutic in patients with partial small-bowel obstruction. A randomized controlled trial of 124 patients showed a 74 percent reduc- tion in the need for surgical intervention in patients receiving gastrografin fluoroscopy within 24 hours of initial presentation.15 Contrast fluoroscopy may also be useful in determining the need for surgery; the pres- ence of contrast material in the rectum within 24 hours of administration has a 97 percent sensitivity for spontaneous resolu- tion of intestinal obstruction.16,17 There are several variations of contrast fluoroscopy. In the small-bowel follow- through study, the patient drinks contrast material, then serial abdominal radiographs are taken to visualize the passage of contrast through the intestinal tract. Enteroclysis involves naso- or oro-duodenal intubation, followed by the instillation of contrast mate- rial directly into the small bowel. Although this study has superior sensitivity compared with small-bowel follow-through,18 it is more labor-intensive and is rarely performed. Rectal fluoroscopy can be helpful in deter- mining the site of a suspected large bowel obstruction. ULTRASONOGRAPHY In patients with high-grade obstruction, ultrasound evaluation of the abdomen has high sensitivity for intestinal obstruction, approaching 85 percent.19 However, because of the wide availability of CT, it has largely replaced ultrasonography as the first-line investigation in stable patients with suspected intestinal obstruction. Ultrasonography remains a valuable investigation for unstable patients with an ambiguous diagnosis and in patients for whom radiation exposure is con- traindicated, such as pregnant women. MAGNETIC RESONANCE IMAGING Magnetic resonance imaging (MRI) may be more sensitive than CT in the evaluation of intestinal obstruction.20 MRI enteroclysis, which involves intubation of the duodenum and infusion of contrast material directly into the small bowel, can more reliably determine the location and cause of obstruc- tion.21 However, because of the ease and cost- effectiveness of abdominal CT, MRI remains an investigational or adjunctive imaging modality for intestinal obstruction. Treatment Management of intestinal obstruction is directed at correcting physiologic derange- ments caused by the obstruction, bowel rest, and removing the source of obstruction. The
  • 6. Intestinal Obstruction 164 American Family Physician www.aafp.org/afp Volume 83, Number 2 ◆ January 15, 2011 former is addressed by intravenous fluid resuscitation with isotonic fluid. The use of a bladder catheter to closely monitor urine output is the minimum requirement for gauging the adequacy of resuscitation; other invasive measures, such as arterial canaliza- tion or central venous pressure monitoring, can be used as the clinical situation war- rants. Antibiotics are used to treat intestinal overgrowth of bacteria and translocation across the bowel wall.22 The presence of fever and leukocytosis should prompt inclusion of antibiotics in the initial treatment regimen. Antibiotics should have coverage against gram-negative organisms and anaerobes, and the choice of a specific agent should be determined by local susceptibility and avail- ability. Aggressive replacement of electro- lytes is recommended after adequate renal function is confirmed. The decision to perform surgery for intes- tinal obstruction can be difficult. Perito- nitis, clinical instability, or unexplained leukocytosis or acidosis are concerning for abdominal sepsis, intestinal ischemia, or perforation; these findings mandate imme- diate surgical exploration. Patients with an obstruction that resolves after reduction of a hernia should be scheduled for elective hernia repair, whereas immediate surgery is required in patients with an irreducible or strangulated hernia. Stable patients with a history of abdominal malignancy or high suspicion for malignancy should be thor- oughly evaluated for optimal surgical plan- ning. Abdominal malignancy can be treated with primary resection and reconstruction or palliative diversion, or placement of vent- ing and feeding tubes. Treatment of stable patients with intesti- nal obstruction and a history of abdominal surgery presents a challenge. Conservative management of a high-grade obstruction should be attempted initially, using intesti- nal intubation and decompression, aggres- sive intravenous rehydration, and antibiotics. The inclusion of oral magnesium hydroxide, simethicone, and probiotics decreased the length of hospitalization in a randomized controlled trial of 144 patients with partial small bowel obstructions (number needed to treat = 7).23 Caution should be used when clinical and radiologic evidence suggest com- pleteobstruction,becausetheuseofintestinal stimulation can exacerbate the obstruction and precipitate intestinal ischemia. SORT: KEY RECOMMENDATIONS FOR PRACTICE Clinical recommendation Evidence rating References Comments Abdominal radiography is an effective initial examination in patients with suspected intestinal obstruction. C 6, 7 Radiography has greater sensitivity in high-grade obstruction than in partial obstruction. Computed tomography is warranted when radiography indicates high-grade intestinal obstruction or is inconclusive. C 8-10 Computed tomography can reliably determine the cause of obstruction, and whether serious complications are present, in most patients with high-grade obstructions. Upper gastrointestinal fluoroscopy with small bowel follow-through can determine the need for surgical intervention in patients with partial obstruction. C 14, 15 Contrast material that passes into the cecum within four hours of oral administration is highly predictive of successful nonoperative management. Antibiotics can protect against bacterial translocation and subsequent bacteremia in patients with intestinal obstruction. C 22 Enteric bacteria have been found in cultures from serosal scrapings and mesenteric lymph node biopsy in patients requiring surgery. Clinically stable patients can be treated conservatively with bowel rest, intubation and decompression, and intravenous fluid resuscitation. A 22-26 Several randomized controlled trials have shown that surgery can be avoided with conservative management. Surgery is warranted in patients with intestinal obstruction that does not resolve within 48 hours after conservative therapy is initiated. B 25 Study found that conservative management beyond 48 hours does not diminish the need for surgery, but increases surgical morbidity. A = consistent, good-quality patient-oriented evidence; B = inconsistent or limited-quality patient-oriented evidence; C = consensus, disease- oriented evidence, usual practice, expert opinion, or case series. For information about the SORT evidence rating system, go to http://www.aafp. org/afpsort.xml.
  • 7. Intestinal Obstruction January 15, 2011 ◆ Volume 83, Number 2 www.aafp.org/afp American Family Physician 165 Conservative management is successful in 40 to 70 percent of clinically stable patients, with a higher success rate in those with partial obstruction.24-26 Although conservative man- agement is associated with shorter initial hos- pitalization (4.9 versus 12 days), there is also a higher rate of eventual recurrence (40.5 versus 26.8 percent).27 With conservative manage- ment, resolution generally occurs within 24 to 48 hours. Beyond this time frame, the risk of complications, including vascular compro- mise, increases. If intestinal obstruction is not resolved with conservative management, sur- gical evaluation is required.25 Figures 2 through 4 provided by Cirrelda J. Cooper, MD. The Authors PATRICK G. JACKSON, MD, is chief of gastrointestinal sur- gery at Georgetown University Hospital, Washington, DC. MANISH RAIJI, MD, is a third year surgical resident at Georgetown University Hospital. Address correspondence to Patrick G. Jackson, MD, 3800 Reservoir Rd., 4th Floor, PHC, Washington, DC 20007. Reprints are not available from the authors. Author disclosure: Nothing to disclose. REFERENCES 1. Irvin TT. Abdominal pain: a surgical audit of 1190 emer- gency admissions. Br J Surg. 1989;76(11):1121-1125. 2. Wright HK, O’Brien JJ, Tilson MD. Water absorption in experimental closed segment obstruction of the ileum in man. Am J Surg. 1971;121(1):96-99. 3. Wangensteen OH. Understanding the bowel obstruc- tion problem. Am J Surg. 1978;135(2):131-149. 4. Rana SV, Bhardwaj SB. Small intestinal bacterial over- growth. Scand J Gastroenterol. 2008;43(9):1030-1037. 5. Shelton BK. Intestinal obstruction [published correction appears in AACN Clin Issues. 2000;11(1):following table of contents]. AACN Clin Issues. 1999;10(4):478-491. 6. Maglinte DD, Heitkamp DE, Howard TJ, Kelvin FM, Lap- pas JC. Current concepts in imaging of small bowel obstruction. Radiol Clin North Am. 2003;41(2):263-283. 7. Lappas JC, Reyes BL, Maglinte DD. Abdominal radiog- raphy findings in small-bowel obstruction: relevance to triage for additional diagnostic imaging. AJR Am J Roentgenol. 2001;176(1):167-174. 8. Stoker J, van Randen A, Laméris W, Boermeester MA. Imaging patients with acute abdominal pain. Radiology. 2009;253(1):31-46. 9. Suri S, Gupta S, Sudhakar PJ, Venkataramu NK, Sood B, Wig JD. Comparative evaluation of plain films, ultra- sound and CT in the diagnosis of intestinal obstruction. Acta Radiol. 1999;40(4):422-428. 10. Furukawa A, Yamasaki M, Furuichi K, et al. Helical CT in the diagnosis of small bowel obstruction. Radiographics. 2001;21(2):341-355. 11. Gazelle GS, Goldberg MA, Wittenberg J, Halpern EF, Pinkney L, Mueller PR. Efficacy of CT in distinguishing small-bowel obstruction from other causes of small-bowel dilatation. AJR Am J Roentgenol. 1994;162(1):43-47. 12. Frager DH, Baer JW, Rothpearl A, Bossart PA. Distinc- tion between postoperative ileus and mechanical small- bowel obstruction: value of CT compared with clinical and other radiographic findings. AJR Am J Roentgenol. 1995;164(4):891-894. 13. Ros PR, Huprich JE. ACR Appropriateness Criteria on suspected small-bowel obstruction. J Am Coll Radiol. 2006;3(11):838-841. 14. Hayanga AJ, Bass-Wilkins K, Bulkley GB. Current man- agement of small-bowel obstruction. Adv Surg. 2005; 39:1-33. 15. Choi HK, Chu KW, Law WL. Therapeutic value of gas- trografin in adhesive small bowel obstruction after unsuccessful conservative treatment: a prospective ran- domized trial. Ann Surg. 2002;236(1):1-6. 16. Abbas S, Bissett IP, Parry BR. Oral water soluble contrast for the management of adhesive small bowel obstruc- tion. Cochrane Database Syst Rev. 2007;(3):CD004651. 17. Anderson CA, Humphrey WT. Contrast radiography in small bowel obstruction: a prospective, randomized trial. Mil Med. 1997;162(11):749-752. 18. Dunn JT, Halls JM, Berne TV. Roentgenographic con- trast studies in acute small-bowel obstruction. Arch Surg. 1984;119(11):1305-1308. 19. Lim JH, Ko YT, Lee DH, Lee HW, Lim JW. Determining the site and causes of colonic obstruction with sonog- raphy. AJR Am J Roentgenol. 1994;163(5):1113-1117. 20. Matsuoka H, Takahara T, Masaki T, Sugiyama M, Hachiya J, Atomi Y. Preoperative evaluation by magnetic resonance imaging in patients with bowel obstruction. Am J Surg. 2002;183(6):614-617. 21. Wiarda BM, Horsthuis K, Dobben AC, et al. Magnetic resonance imaging of the small bowel with the true FISP sequence: intra- and interobserver agreement of enteroclysis and imaging without contrast material. Clin Imaging. 2009;33(4):267-273. 22. Sagar PM, MacFie J, Sedman P, May J, Mancey-Jones B, Johnstone D. Intestinal obstruction promotes gut trans- location of bacteria. Dis Colon Rectum. 1995;38(6): 640-644. 23. Chen SC, Yen ZS, Lee CC, et al. Nonsurgical manage- ment of partial adhesive small-bowel obstruction with oral therapy: a randomized controlled trial. CMAJ. 2005;173(10):1165-1169. 24. Mosley JG, Shoaib A. Operative versus conservative man- agement of adhesional intestinal obstruction. Br J Surg. 2000;87(3):362-373. 25. Fevang BT, Jensen D, Svanes K, Viste A. Early opera- tion or conservative management of patients with small bowel obstruction? Eur J Surg. 2002;168(8-9):475-481. 26. Williams SB, Greenspon J, Young HA, Orkin BA. Small bowel obstruction: conservative vs. surgical manage- ment. Dis Colon Rectum. 2005;48(6):1140-1146. 27. Cox MR, Gunn IF, Eastman MC, Hunt RF, Heinz AW. The safety and duration of non-operative treatment for adhesive small bowel obstruction. Aust N Z J Surg. 1993;63(5):367-371.