The document discusses the need for disruption in science. It notes that up to 70% of academic research cannot be reproduced, representing a waste of money and effort. Additionally, existing research systems are hindering progress by locking scientists into old mechanisms and traditions that persist due to influential people resisting change. However, the document expresses hope that systems can be improved by rethinking how knowledge is defined, produced and shared in order to increase reproducibility and openness in scientific research.