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Commonly Renal Diseases
associated with urine elements
Kridsada Sirisabhabhorn, M.MT.
Division of Cilnical Microscopy and Parasitology, Medical Technology
Laboratory, Thammasat Charlermprakiet Hospital
Pathumtani, Thailand
July 12th 2013
Clinical guide line on urine strip
• Color : DI, Hepatic disease, GM, GN
• Sp.gr. : DI, RTN
• pH : Calculi, Stone
• Leuk. : Bacterial infection / Immune ?? / Allergy
• Protein : GM, GN, NS, RF, Sperm
• Nitrite : Bacterial infection
• Glucose : DM
• Ketone : DM, MS
• Bilirubin : Hepatic disease
• Urobilinogen : Large intestinal disorder
• Erythrocyte : Inflammation, bleeding, GM, GN, CA
Major groups of commonly renal
disease
1. Cystitis / Urethritis
2. Pyelonephritis
3. Uroliths / Renal calculi / Nephroliths
4. Glomerulonephritis [GN]
5. Nephrotic syndrome [NS]
6. Renal failure [RF] & End stage of renal failure
7. Renal tubular necrosis [RN]
8. Carcinomas / Malignant or Tumor
9. Neurogenic bladder disorder
10. Disorder associated with hepatic diseases
11.Polycystic kidney disease
• Acute phase: remaining symptom < 3 weeks
Urine elements presented : Cell cast
• Chronic phase : remaining symptom > 4 weeks
Urine elements presented : Broad
cast, Granular cast and Waxy cast, Macrophage
1. Cystitis & Urethritis
• Etiology
Bacterial, Fungal infection
• Symptom and appearance
Greenish, cloudy, bloody with foul smelling of
urine, dysuria
• Microscopic finding
Pyuria, WBCs, Bacteria numerous no cast
• Treatment
Antibiotics
2. Pyelonephritis
• Etiology
Bacterial or yeast infection at renal pelvis
• Symptom & appearance
Lumbar pain, fever, chills, nausea, vomitting
urine greenish, urine cloudy, Proteinuria
• Microscopic finding
Pyuria, WBCs, Bacteria numerous with WBC
cast
• Treatment
Antibiotics
3. Renal calculi
• Etiology
Calcium oxalate, uric acid, cystine, struvite
Hyperparathyroidism, Gout, Neoplasm, UTI
• Symptom and appearance
Flank
pain, Hematuria, Nausea, Vomitting, Fever
• Microscopic finding
Crystaluria & Hematuria on cast
Isomorphic RBCs
4. Glomerulonephritis [GN]
• Etiology
Damaged of glomerulus due to
- Ag-Ab complex reaction
- Virus : HIV, Hepatitis
- DM
- Hypertension
Clinical sign & Symptoms
- Smoky brown
hematuria, Oliguria, Adema, Lumbar
pain, Proteinuria, High BUN Creatinine, GFR
Microscopic finding
***Dysmorphic rbc, RBC cast, Hb cast
Renal biopsy positive with immune complex
Glomerular filtration rate (GFR)
5. Nephrotic syndrome [NS]
• Etiology
GM, GN, DM, hypertension, SLE, Drugs, CA
• Symptom & appearance
Edema, shortness of breath, High
BUN, Creatinine, K+, Heavy proteinuria, Low level of
serum albumin, urine cloudy, GFR
• Microscopic finding
**Oval fat body, Fatty cast, Cholesterol
crystal** many hyaline cast, High count of
RBCs, WBCs and Casts.
Remaining long term of NS can progress to
end stage renal disease.
Pathogenesis of NS
6. Renal Failure [RF]
• Etiology
Long term standing of kidney disease
• Microscopic finding
Telescopic urine sediment with Broad waxy
cast and very low of GFR value [< 15]
High level of BUN & Creatinine
7. Renal tubular necrosis [RTN]
• Etiology
RTE dysfunction, Hypoxia, Chemical toxic
agent
• Symptom & appearance
Diluted urine sp.gr. < 1.010, BUN, Crea.
• Microscopic finding
High count of renal epithelial & renal
epithelial cast, RBCs
8. Neoplasm / CA / Tumor
• Etiology : Diversity factors
• Appearance : Urine bloody
• Microscopic finding
- Abnormal cell presented in atypical
morphology ex. Glandular, Ball, Signet ring
formation etc.
- Should be report that “Abnormal cell
found
9. Neurogenic bladder disorder
• Etiology
Bladder nerve or spinal cord damaged
• Appearance
Urinary incontinence
Difficultly to control urine flowing
• Microscopic finding
Some case found spermatozoa
10. Hepatic disease
• Etiology
Ex. expose hazard chemical or toxic agent
congenital
hepatitis virus
bile obstruction or entero hepatic tract obstruction
etc.
• Appearance : Bilirubinuria, Urobilinogenuria, Dark yellow or
Brown urine color
• Microscopic finding
Bilirubin, Leucine crystal, bilirubin
granule, hemosiderin granule, pigment cast, bile cast, bilirubin
cast
Often, appear with many count of renal tubular
epithelial and renal epithelial cast.
11. Polycystic kidney disease
• Etiology – Genetic defect
• Symptom & appearance
Mutiple, grapelike, fluid-filled cysts
Lumbar pain
Hypertension
• Microscopic finding
Hematuria
1. Polycystic kidney disease : Hematuria
2. Pyelonephritis : Wbc casts & caudate cells
3. Renal calculi : Isomorphic rbc & crystal
4. Tubular necrosis [TN] : Renal epthelial cast & renal epithelial
5. Glomerulonephritis : Dysmorphic rbc & rbc cast
6. Nephrotic syndrome : Oval fat bodies, fatty cast & cholesterol
crystal
7. Renal failure [RF] : Broad granular, Broad waxy and waxy cast with
telescopic urine sediments
8. Neoplasm of kidney : Abnormal cells, maybe with sheet cause of
over cell perforation.
9. Cystitis : Numerous of wbc and bacteria, but no cast present.
Conclusions of clinical specific urine elements with
major types of kidney diseases
Reference
• Manual of training in Urinalysis : Intergration
and Validation of Laboratory Results by Assis.
Prof. Dr. Yupin Aniwatangkoora and Assoc.
Prof. Dr. Nattaya Sae-ung. Faculty of
Associated Medical Sciences, Khon Kaen
University, Thailand

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Commonly renal diseases associated with urine elements/Kridsada31

  • 1. Commonly Renal Diseases associated with urine elements Kridsada Sirisabhabhorn, M.MT. Division of Cilnical Microscopy and Parasitology, Medical Technology Laboratory, Thammasat Charlermprakiet Hospital Pathumtani, Thailand July 12th 2013
  • 2. Clinical guide line on urine strip • Color : DI, Hepatic disease, GM, GN • Sp.gr. : DI, RTN • pH : Calculi, Stone • Leuk. : Bacterial infection / Immune ?? / Allergy • Protein : GM, GN, NS, RF, Sperm • Nitrite : Bacterial infection • Glucose : DM • Ketone : DM, MS • Bilirubin : Hepatic disease • Urobilinogen : Large intestinal disorder • Erythrocyte : Inflammation, bleeding, GM, GN, CA
  • 3.
  • 4. Major groups of commonly renal disease 1. Cystitis / Urethritis 2. Pyelonephritis 3. Uroliths / Renal calculi / Nephroliths 4. Glomerulonephritis [GN] 5. Nephrotic syndrome [NS] 6. Renal failure [RF] & End stage of renal failure 7. Renal tubular necrosis [RN] 8. Carcinomas / Malignant or Tumor 9. Neurogenic bladder disorder 10. Disorder associated with hepatic diseases 11.Polycystic kidney disease
  • 5. • Acute phase: remaining symptom < 3 weeks Urine elements presented : Cell cast • Chronic phase : remaining symptom > 4 weeks Urine elements presented : Broad cast, Granular cast and Waxy cast, Macrophage
  • 6. 1. Cystitis & Urethritis • Etiology Bacterial, Fungal infection • Symptom and appearance Greenish, cloudy, bloody with foul smelling of urine, dysuria • Microscopic finding Pyuria, WBCs, Bacteria numerous no cast • Treatment Antibiotics
  • 7. 2. Pyelonephritis • Etiology Bacterial or yeast infection at renal pelvis • Symptom & appearance Lumbar pain, fever, chills, nausea, vomitting urine greenish, urine cloudy, Proteinuria • Microscopic finding Pyuria, WBCs, Bacteria numerous with WBC cast • Treatment Antibiotics
  • 8. 3. Renal calculi • Etiology Calcium oxalate, uric acid, cystine, struvite Hyperparathyroidism, Gout, Neoplasm, UTI • Symptom and appearance Flank pain, Hematuria, Nausea, Vomitting, Fever • Microscopic finding Crystaluria & Hematuria on cast Isomorphic RBCs
  • 9. 4. Glomerulonephritis [GN] • Etiology Damaged of glomerulus due to - Ag-Ab complex reaction - Virus : HIV, Hepatitis - DM - Hypertension Clinical sign & Symptoms - Smoky brown hematuria, Oliguria, Adema, Lumbar pain, Proteinuria, High BUN Creatinine, GFR Microscopic finding ***Dysmorphic rbc, RBC cast, Hb cast Renal biopsy positive with immune complex
  • 11. 5. Nephrotic syndrome [NS] • Etiology GM, GN, DM, hypertension, SLE, Drugs, CA • Symptom & appearance Edema, shortness of breath, High BUN, Creatinine, K+, Heavy proteinuria, Low level of serum albumin, urine cloudy, GFR • Microscopic finding **Oval fat body, Fatty cast, Cholesterol crystal** many hyaline cast, High count of RBCs, WBCs and Casts. Remaining long term of NS can progress to end stage renal disease.
  • 13. 6. Renal Failure [RF] • Etiology Long term standing of kidney disease • Microscopic finding Telescopic urine sediment with Broad waxy cast and very low of GFR value [< 15] High level of BUN & Creatinine
  • 14. 7. Renal tubular necrosis [RTN] • Etiology RTE dysfunction, Hypoxia, Chemical toxic agent • Symptom & appearance Diluted urine sp.gr. < 1.010, BUN, Crea. • Microscopic finding High count of renal epithelial & renal epithelial cast, RBCs
  • 15. 8. Neoplasm / CA / Tumor • Etiology : Diversity factors • Appearance : Urine bloody • Microscopic finding - Abnormal cell presented in atypical morphology ex. Glandular, Ball, Signet ring formation etc. - Should be report that “Abnormal cell found
  • 16. 9. Neurogenic bladder disorder • Etiology Bladder nerve or spinal cord damaged • Appearance Urinary incontinence Difficultly to control urine flowing • Microscopic finding Some case found spermatozoa
  • 17. 10. Hepatic disease • Etiology Ex. expose hazard chemical or toxic agent congenital hepatitis virus bile obstruction or entero hepatic tract obstruction etc. • Appearance : Bilirubinuria, Urobilinogenuria, Dark yellow or Brown urine color • Microscopic finding Bilirubin, Leucine crystal, bilirubin granule, hemosiderin granule, pigment cast, bile cast, bilirubin cast Often, appear with many count of renal tubular epithelial and renal epithelial cast.
  • 18. 11. Polycystic kidney disease • Etiology – Genetic defect • Symptom & appearance Mutiple, grapelike, fluid-filled cysts Lumbar pain Hypertension • Microscopic finding Hematuria
  • 19. 1. Polycystic kidney disease : Hematuria 2. Pyelonephritis : Wbc casts & caudate cells 3. Renal calculi : Isomorphic rbc & crystal 4. Tubular necrosis [TN] : Renal epthelial cast & renal epithelial 5. Glomerulonephritis : Dysmorphic rbc & rbc cast 6. Nephrotic syndrome : Oval fat bodies, fatty cast & cholesterol crystal 7. Renal failure [RF] : Broad granular, Broad waxy and waxy cast with telescopic urine sediments 8. Neoplasm of kidney : Abnormal cells, maybe with sheet cause of over cell perforation. 9. Cystitis : Numerous of wbc and bacteria, but no cast present. Conclusions of clinical specific urine elements with major types of kidney diseases
  • 20. Reference • Manual of training in Urinalysis : Intergration and Validation of Laboratory Results by Assis. Prof. Dr. Yupin Aniwatangkoora and Assoc. Prof. Dr. Nattaya Sae-ung. Faculty of Associated Medical Sciences, Khon Kaen University, Thailand