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Lars Juhl Jensen
Large-scale integration of data and
text
Lars Juhl Jensen
Large-scale integration of data and
text
Ph.D.
sequence analysis
postdoc
staff scientist
protein networks
cellular signalling
group leader
cofounder
data integration
omics data
association networks
text mining
biomedical literature
electronic health records
association networks
guilt by association
STRING
Franceschini et al., Nucleic Acids Research, 2013
1100+ genomes
genomic context
gene fusion
Korbel et al., Nature Biotechnology, 2004
operons
Korbel et al., Nature Biotechnology, 2004
bidirectional promoters
Korbel et al., Nature Biotechnology, 2004
phylogenetic profiles
Korbel et al., Nature Biotechnology, 2004
a real example
Cell
Cellulosomes
Cellulose
experimental data
gene coexpression
physical interactions
Jensen & Bork, Science, 2008
genetic interactions
Beyer et al., Nature Reviews Genetics, 2007
curated knowledge
pathways
Letunic & Bork, Trends in Biochemical Sciences, 2008
many databases
different formats
different identifiers
variable quality
not comparable
not same species
hard work
(Ph.D. students)
quality scores
von Mering et al., Nucleic Acids Research, 2005
calibrate vs. gold standard
von Mering et al., Nucleic Acids Research, 2005
homology-based transfer
Franceschini et al., Nucleic Acids Research, 2013
missing most of the data
text mining
>10 km
too much to read
computer
as smart as a dog
teach it specific tricks
named entity recognition
comprehensive lexicon
cyclin dependent kinase 1
CDC2
flexible matching
cyclin dependent kinase 1
cyclin-dependent kinase 1
orthographic variation
CDC2
hCdc2
“black list”
SDS
augmented browsing
Reflect
browser add-on
real-time text mining
Pafilis, O’Donoghue, Jensen et al., Nature Biotechnology, 2009
O’Donoghue et al., Journal of Web Semantics, 2010
information extraction
co-mentioning
within documents
within paragraphs
within sentences
NLP
Natural Language Processing
grammatical analysis
Gene and protein names
Cue words for entity
recognition
Verbs for relation extraction
[nxexpr The expression of
[nxgene the cytochrome
genes
[nxpg CYC1 and CYC7]]]
is controlled by
[nxpg HAP1]
more precise
worse recall
related web resources
STITCH
STRING + 300k chemicals
stitch-db.org
COMPARTMENTS
compartments.jensenlab.org
TISSUES
tissues.jensenlab.org
DISEASES
diseases.jensenlab.org
general framework
curated knowledge
experimental data
text mining
computational predictions
common identifiers
quality scores
visualization
web resources
download files
why so many?
Swiss army knife syndrome
targeted resources
common infrastructure
medical data mining
Jensen et al., Nature Reviews Genetics, 2012
opt-out
opt-in
centralized registries
structured data
Jensen et al., Nature Reviews Genetics, 2012
14 years
6.2 million patients
119 million diagnoses
distributions
Jensen et al., submitted, 2014
diagnosis trajectories
Jensen et al., submitted, 2014
Jensen et al., submitted, 2014
complex trajectories
Jensen et al., submitted, 2014
confounding factors
correlation causation≠
electronic health records
unstructured data
Danish
busy doctors
pharmacovigilance
custom dictionaries
drugs
adverse drug events
typo rules
complex filters
Eriksson et al., Drug Safetey, 2014
new adverse drug reactions
Eriksson et al., Drug Safety, 2014
Drug substance ADE p-value
Chlordiazepoxide Nystagmus 4.0e-8
Simvastatin Personality
changes
8.4e-8
Dipyridamole Visual impairment 4.4e-4
Citalopram Psychosis 8.8e-4
Bendroflumethiazi
de
Apoplexy 8.5e-3
direct medical implications
Acknowledgments
STRING/STITCH
Christian von Mering
Damian Szklarczyk
Michael Kuhn
Manuel Stark
Samuel Chaffron
Chris Creevey
Jean Muller
Tobias Doerks
Philippe Julien
Alexander Roth
Milan Simonovic
Jan Korbel
Berend Snel
Martijn Huynen
Peer Bork
Text mining
Sune Frankild
Jasmin Saric
Evangelos Pafilis
Kalliopi Tsafou
Alberto Santos
Janos Binder
Heiko Horn
Michael Kuhn
Nigel Brown
Reinhardt Schneider
Sean O’ Donoghue
EHR mining
Anders Boeck
Jensen
Peter Bjødstrup
Jensen
Robert Eriksson
Francisco S. Roque
Henriette Schmock
Marlene Dalgaard
Massimo Andreatta
Thomas Hansen
Karen Søeby
Søren Bredkjær
Anders Juul
Tudor Oprea
Pope Moseley
Thomas Werge
Søren Brunak
Large-scale integration of data and text

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Large-scale integration of data and text