Objective Time Content Teachers
Celiac disease also known as gluten induced enteropathy, gluten
sensitive enteropathy and celiac sprue.
It is a disease of the proximal small intestine characterized by abnormal
mucosa and permanent intolerance to gluten.
More frequent in Europeans than in Americans and is rarely reported in
Asians or blacks.
Previously it was 1 in 6000 individuals, recently it was 1 in 250
Mutation of Genes
Absence of the healthy bacteria which helps in the
Gluten- Consuming gluten triggers the abnormal immune
system response that causes celiac disease
Acute, severe episodes of profuse watery diarrhea and vomiting
May be precipitated by:
Infections (specially gastrointestinal)
Prolonged fluid and electrolyte depletion
Bloating and gas
Nausea and vomiting
Biopsy of the small intestine
Serologic test- to detect antibodies to connective tissue
(endomysium & reticulin) and to gliadin.
Antigliadin, antireticulin, & antiendomysial IgG & IgA
antibodies- More specific markers for active celiac disease.
Enzyme tissue transglutaminase (tTG),
The diet should be gluten free
Restriction on wheat, rye, barley & oats
Correction of nutritional deficiencies with supplements
including vitamins, iron, & Calories
Wong’s. (2005), Essentials of Pediatric nursing, 7th Edition, Elsevier
Publications, New Delhi. Page no: 885- 886.