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Literature ReviewBioactive Materialsby Wanpeng Cao & Larry L. Hench                         Sept 20th 2012By      : Leon V...
Main Objective• To Study about what is:     Tissue attachment     General Theory of Biomaterials     Bioactivity     B...
Tissue attachment of Biomaterials                                                                1.   Nearly Inert  Host T...
Tissue response to near inert implantHost Tissue                                                       Nearly Inert implan...
Tissue response to porous biomaterial implant Host Tissue                                                       Porous bio...
Tissue response to Bioactive Material Host Tissue                                                       Bioactive         ...
Tissue response to Resorbable Material Host Tissue                                                        Resorbable      ...
General Theory of Biomaterial by Hench andEthridgea) Ideal implant material perform as if it   equivalent to host tissueb)...
Bioactivity   Bioactive                             Elicit biological response at   material                              ...
Class in bioactive materials                                            Bioactive                                         ...
Bioactive ceramics• Base component in most bioactive glass and  ceramics (traditional) are SiO2, Na2O,CaO and P2O5.• By co...
Bioactive Bonding                                                           Do not depend on                              ...
Interaction implant-tissue• Extracellular interaction => determined by  surface features (important for protein and  colla...
Calcium Phosphate Ceramics                                            Precipitation                                       ...
Biological apatite and Synthetic HABiological Apatite (HCA)                        Synthetic HAContains carbonate (3.2-5.8...
Bioactive Composite and Coating                  Bioactive Composites                      and Coating                    ...
Bioactive Composite                          Bioactive Composites  Matrix : Bioactive glasses/glass-                   Mat...
Bioactive Composite       Nano Materials and Grain Boundary Engineering Lab   18
Bioactive coating                                Solve mechanical limitation for load-                                    ...
Conclusion• There are many factors influence bioactivity  such as Morphology (surface  morphology,pores), composition, mec...
Future Work• Produce MBG using Sol-Gel methode for temp  400 C and 600C          Nano Materials and Grain Boundary Enginee...
Nano Materials and Grain Boundary Engineering Lab   22
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introduction to bioactive glass

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introduction to bioactive glass

  1. 1. Literature ReviewBioactive Materialsby Wanpeng Cao & Larry L. Hench Sept 20th 2012By : Leon ValentinoAdvisor : Prof. Shao-Ju Shih
  2. 2. Main Objective• To Study about what is:  Tissue attachment  General Theory of Biomaterials  Bioactivity  Bioactive Ceramics  Mechanism of Bioactive Bonding  Bioactive Coating and Composites Nano Materials and Grain Boundary Engineering Lab 2
  3. 3. Tissue attachment of Biomaterials 1. Nearly Inert Host Tissue Response Implant 2. Porous 3. Bioactive 4. Resorbable 1. Morphological fixation 2. Biological fixation 3. Bioactive fixation 4. Replacement with tissue Nano Materials and Grain Boundary Engineering Lab 3
  4. 4. Tissue response to near inert implantHost Tissue Nearly Inert implant Response Non-adherent fibrous capsule (mechanical lock) Micromotion More reactive Degradation of Thicker Non- adherent fibrous implan/tissue capsule layer Nano Materials and Grain Boundary Engineering Lab 4
  5. 5. Tissue response to porous biomaterial implant Host Tissue Porous biomaterial implant Response Ingrowth of tissue into pores (biological fixation) Capable of withstanding more complex stress Provide blood supply Nano Materials and Grain Boundary Engineering Lab 5
  6. 6. Tissue response to Bioactive Material Host Tissue Bioactive Response Material Series of biophysical and biochemical reaction occur at interface Mechanically strong chemical interfacial bond Nano Materials and Grain Boundary Engineering Lab 6
  7. 7. Tissue response to Resorbable Material Host Tissue Resorbable Response Material Resorbable material degrade gradually and replace by natural tissue Must Rate of degradation metabolically must equivalent to accepted regeneration rate Nano Materials and Grain Boundary Engineering Lab 7
  8. 8. General Theory of Biomaterial by Hench andEthridgea) Ideal implant material perform as if it equivalent to host tissueb) Axiom 1. The tissue at interface should be equivalent to normal host tissuec) Axiom 2. Response of the material to physical stimuli should be like that tissue it replaces. Nano Materials and Grain Boundary Engineering Lab 8
  9. 9. Bioactivity Bioactive Elicit biological response at material interface that form bond Create osteogenesis environment Time for more than 50% of interface Bioactivity bonded Nano Materials and Grain Boundary Engineering Lab 9
  10. 10. Class in bioactive materials Bioactive Material Class A Class B (Osteoproductive) (Osteoconductive)Elicit intracellular Elicit extracellular Elicit extracellular response response response Nano Materials and Grain Boundary Engineering Lab 10
  11. 11. Bioactive ceramics• Base component in most bioactive glass and ceramics (traditional) are SiO2, Na2O,CaO and P2O5.• By comparing composition of SiO2-Na2O-CaO with P2O5 constant, a diagram of bioactivity are like this: Nano Materials and Grain Boundary Engineering Lab 11
  12. 12. Bioactive Bonding Do not depend on Stage 1-5 the presence of tissues. Nano Materials and Grain Boundary Engineering Lab 12
  13. 13. Interaction implant-tissue• Extracellular interaction => determined by surface features (important for protein and collagen adsorption)• Intracellular interaction => caused by soluble silicon release from glass surface. Soluble silicon => potent mitogen => enhanced alkaline phospatase activity and osteocalcin (product of resorption of bone) release Nano Materials and Grain Boundary Engineering Lab 13
  14. 14. Calcium Phosphate Ceramics Precipitation Hydrothermal reactionCalcium Phosphate Sol-Gel Solid state reaction Hydrolysis Nano Materials and Grain Boundary Engineering Lab 14
  15. 15. Biological apatite and Synthetic HABiological Apatite (HCA) Synthetic HAContains carbonate (3.2-5.8 wt%) Much more Isotropic than biological apatiteContains minor element (Mg,Na,K) and Much larger in grain sizetrace element (Sr,Pb,Ba) and acidphosphate.Contains organic material which exist ingrain boundaries and has large influenceto physical-chemical and biologicalproperties Nano Materials and Grain Boundary Engineering Lab 15
  16. 16. Bioactive Composite and Coating Bioactive Composites and Coating Have much better biomechanical properties than bioactive ceramics Nano Materials and Grain Boundary Engineering Lab 16
  17. 17. Bioactive Composite Bioactive Composites Matrix : Bioactive glasses/glass- Matrix : biocompatible Polymer ceramics Reinforce : metal fibers or tough Reinforce : Bioactive ceramic part glass/ceramic particle or fibers Mechanical properties Elastic moduli > bone close to bone Stress shielding Nano Materials and Grain Boundary Engineering Lab 17
  18. 18. Bioactive Composite Nano Materials and Grain Boundary Engineering Lab 18
  19. 19. Bioactive coating Solve mechanical limitation for load- bearing application Use Metals and alumina (medical grade)Bioactive Coating as susbtrate coated by HA,TCP,Bioglass Calcium Phospate deposit using HIP, plasma/flame spraying,ion beam sputtering, sol-gel deposition and RF sputtering Good for short term stabilization but cannot be used for long term due to deficiencies Nano Materials and Grain Boundary Engineering Lab 19
  20. 20. Conclusion• There are many factors influence bioactivity such as Morphology (surface morphology,pores), composition, mechanical properties,etc.• To achieve biochemically and biophysically strong interface between host tissues-implant is very important Nano Materials and Grain Boundary Engineering Lab 20
  21. 21. Future Work• Produce MBG using Sol-Gel methode for temp 400 C and 600C Nano Materials and Grain Boundary Engineering Lab 21
  22. 22. Nano Materials and Grain Boundary Engineering Lab 22

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