1. RESOURCES FOR CLINICAL
REASONING EXERCISE
KSOM Psychiatry
Clerkship, 2014-2015
Lynn Kysh, MLIS
Information Services
Librarian
2. LEARNING OBJECTIVES
Formulate a clinical research question from clerkship
experience
Identify databases relevant to psychiatry and conduct
an effective search
Apply basic criteria to appraise evidence
Retrieve available resources for more information on
citation styles, search strategies, etc.
3. MEDICAL
STUDENTS
YEARS 3-4
PORTAL
Available on the
Norris Medical
Library Homepage
usc.edu/nml
norris.usc.libguides.
com/medyrs3-4
4. REFRESHER: QUESTION TYPES
What is the disorder?
What causes it?
How does it present?
How can it be prevented?
What are treatment options?
Background Questions
Foreground
Questions
Clinical research question
Information for an actual
patient
PICO based
Experience with condition
5. FORMULATE A CLINICAL RESEARCH
QUESTION
Scenario:
Patient diagnosed with schizophrenia is
being treated with an anti-psychotic drug
(olanzapine).
This drug is causing patient to gain
weight. You wonder if nutrition therapy
would be effective for weight loss.
6. FORMULATE A CLINICAL RESEARCH
QUESTION: THERAPY
Problem/Patient/Popul
ation
Intervention/Indicator
Comparison/Control
(if any)
Outcome
Weight gain with anti-psychotic
olanzapine
Nutrition therapy
None
Continued treatment with
olanzapine while managing
healthy weight
8. TYPES OF CLINICAL QUESTIONS
How is the problem treated?
What causes the problem?
What is the frequency of the
problem?
Does this person have the
problem?
Who will get the problem?
Therapy
Etiology, Risk Factors
Frequency
Diagnosis
Prognosis, Prediction
9. AN IDEA FOR AN ETIOLOGY
QUESTION
Does the recreational use of marijuana
increase the incidence of psychosis
among adult men?
10. FORMULATE A CLINICAL RESEARCH
QUESTION: ETIOLOGY
Problem/Patient/Popul
ation
Intervention/Indicator
Comparison/Control
(if any)
Outcome
Adult men
Recreational use of marijuana
No recreational use of marijuana
Increased incidence of psychosis
11. COMMON MISTAKE IN
FORMULATING A RESEARCH
QUESTION
What is the most effective treatment of
schizophrenia?
ďWho is the patient?
ďAge, gender, comorbidities, etc.
ďWhat treatments are known to be effective?
ďPrimary research does not answer general questions
ďConsider background information tools (UpToDate,
AccessMedicine, etc.)
14. Journal articles, meeting abstracts, dissertations, book chapters
Search with synonyms and narrower terms
Quotes to search phrase; * for truncation
15. SELECT 5 BEST ARTICLES
1. Does this article address my research
question (PICO)?
2. Is this the best article for my research
question?
3. Does this article rely on sound research
methodologies?
16. 1.DOES THIS ARTICLE ADDRESS
MY RESEARCH QUESTION
(PICO)?
RememberâŚ
Problem/Patient
Intervention
Comparison
Outcome
Source: Flahery, RJ. âA simple method for evaluating the clinical literature.â Family Practice
Management. May 2004.
17. Patient
Problem
Interventio
n
Compariso
n
(if any)
Outcome
Schizophrenia or schizoaffective disorder (DSM IV)
Men and women; 19-64 y/o
Olanzapine for 12 weeks
7% or more weight gain
Associated weight gain with olanzapine
Diet management: food diary, dietician consultation
Exercise management: exercise diary, exercise manager
None
Physical exam (BMI measurement)
Pulse rate
Blood pressure
18. 2. IS THIS THE BEST ARTICLE
FOR MY RESEARCH QUESTION?
RememberâŚ
Problem/Patient
Intervention
Comparison
Outcome
AddâŚ
Date of Publication
Times cited (Web of
Knowledge, PSYCinfo, Google
Scholar)
Publication Type
Source: Flahery, RJ. âA simple method for evaluating the clinical literature.â Family Practice
Management. May 2004.
20. PYRAMID OF PUBLICATION TYPES
Guidelines
Systematic
Reviews
Randomized
Controlled Trials
Cohort Studies
Case Series, Case Reports
Higher Quality of Information
Fewer Articles
Lower Quality of Information
More Articles
21. Date
Times Cited
Publication Type
April 2006
69 (Web of Science)
71 (PsycINFO)
101 (Google Scholar)
Randomized Control Trial (RCT)
22. 3. DOES THIS ARTICLE RELY ON
SOUND RESEARCH
METHODOLOGIES?
Critical Appraisal Charts for...
⢠Systematic Reviews
⢠Therapy Studies
⢠Diagnosis Studies
⢠Prognosis Studies
⢠Harm/Etiology
23. Randomization
Allocation
Concealment
Similar Baseline
Characteristics
Blinding
To what extent?
Follow up
Intention to Treat
Yes (maybe); methods not described
Not described
Yes
No
Not described
Yes
24. SELECT 5 BEST ARTICLES
1. Does this article address my research question
(PICO)?
YES
2. Is this the best type of article for my research
question?
YES
3. Does this article rely on sound research
methodologies?
MOSTLY
25. WHAT I AM LOOKING FOR ON THE
ASSIGNMENT
1 Point â Reference 5 Articles
1
.75
.5
.25
0
List four or five articles that relate to the research question
and relevant PICO elements.
List three articles that relate to the research question and
relevant PICO elements.
List two articles that relate to the research question and
relevant PICO elements.
List one article that relates to the research question and
relevant PICO elements.
List no articles that relate to the research question and
relevant PICO elements.
26. WHAT I AM LOOKING FOR ON THE
ASSIGNMENT
1 Point â Provide One Article that Meets Assessment Criteria
1
.5
0
At least one article listed meets assessment
criteria of high quality evidence (combination of
publication type, currency, statistics, times cited,
aApt pleraaissta ol)n. e article listed meets some
assessment criteria ranking it as medium quality
evidence (combination of publication type,
cNuor raernticcyle, ss tlaisttisetdic ms,e teimt aensy c aitsesde,s aspmpernatis carli)t.eria
ranking all articles as low quality evidence.
29. LEARNING OBJECTIVES
Formulate a clinical research question from clerkship
experience
Identify databases relevant to psychiatry and conduct
an effective search
Apply basic criteria to appraise evidence
Retrieve available resources for more information on
citation styles, search strategies, etc.