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DNA Repair Mechanisms,[object Object],Maria Fernanda Sánchez Rico,[object Object],Third Semester,[object Object],Medicine – UPB,[object Object],2010,[object Object]
Folding,[object Object]
Folding,[object Object]
Introduction,[object Object],Cells have the ability to detect and repair the damage that DNA might suffer.,[object Object],When DNA sequence is damaged and left uncorrected, the cells can accumulate mutations and function improperly. ,[object Object],To prevent these kinds of failures, the cell has DNA repair mechanisms .,[object Object]
  Researchers identify DNA damage repair gene in Fanconi anemia pathwayNewswire The Rockefeller University(July 20, 2010)     ,[object Object]
Researchers identify DNA damage repair gene in Fanconi anemia pathway,[object Object],[object Object]
When one of the proteins in the FA  pathway is damaged, the result is Fanconi Anemia, which can cause various forms of cancer.,[object Object]
Researchers identify DNA damage repair gene in Fanconi anemia pathway,[object Object],[object Object]
The nuclease domain can cut DNA
FAN1’s restorative ability lie in the capacity to interact with ubiquinated proteins.,[object Object]
Drug that Inhibits DNA-repair Enzyme Shrinks Some Breast and Ovarian TumorsNCI Cancer Bulletin(July 13, 2010),[object Object]
Drug that Inhibits DNA-repair Enzyme Shrinks Some Breast and Ovarian Tumors,[object Object],[object Object]
Two phase II clinical trials were made to prove that olaparib shrinks tumors in women with inherited BRCA1 or BRCA2 mutations,[object Object]
27 women received 100mg of olaparib twice a day            tumors shrank in 6 women in this group.,[object Object]
24 received 100mg of olaparib twice a day         tumors shrank in 3 women in this group. ,[object Object]
Medical Utility,[object Object]
Medical Utility,[object Object],[object Object], ,[object Object]
Medical Utility,[object Object],Researchers identify DNA damage repair gene in Fanconi anemia pathway,[object Object],[object Object]
FAN1 might also be related with multiple types of cancer. ,[object Object]
Medical Utility,[object Object],Drug that Inhibits DNA-repair Enzyme Shrinks Some Breast and Ovarian Tumors,[object Object],[object Object]

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