Factors affecting the release of API
Advantages and Disadvantages
Chewing gum has been used worldwide since ancient times
when man experienced the pleasure of chewing a variety of
Chewing gum can be used as a convenient modified-release
drug delivery system.
Commercially available medicated chewing gums are
currently available for ,
travel illness and freshening of breath.
MCG’s are solid, single dosage forms with a base consisting
mainly of gums that are intended to be chewed but not
Medicated Chewing Gum (MCG) is a novel drug delivery
system containing masticatory gum base with
pharmacologically active ingredient and intended to use for
local treatment of mouth diseases or systemic absorption
through oral mucosa.
Chewing gum provides new competitive advantages over
conventional drug delivery system....
Fast onset of action
Higher compliance (easy and discreet administration without
Ready for use.
High acceptance by children.
Water insoluble Water soluble
chewing gum base bulk portion
or treditional compression
Components of gumbase are softened or melted and placed in
a kettle mixer to which sweetners, syrups, active ingredients
and other excipients are added at a definte time.
The gum is then sent through a series of rollers that form into
a thin, wide ribbon.
During this process, a light coating of finely powdered sugar
or sugar substitutes is added to keep the gum away from
sticking and to enhance the flavour.
In a carefully controlled room, the gum is cooled for upto 48
hours. This allows the gum to set properly. Finally the gum is
cut to the desired size and cooled at a carefully controlled
temperature and humidity.
Inter affecting mical
Dose not requires water to swallow. Hence can be take
Excellent for acute medication.
Counteracts dry mouth, prevents candidiasis and caries.
Avoids First Pass Metabolism and thus increases the
bioavailability of drugs.
Fast onset due to rapid release of active ingredients in buccal
cavity and subsequent absorption in systemic circulation.
Stomach does not suffer from direct contact with high
concentrations of active principles, thus reducing the risk of
intolerance of gastric mucosa.
Risk of over dosage.
Sorbitol present in MCG formulation may cause flatulence,
Additives in gum like flavouring agent, Cinnamon can cause
Ulcers in oral cavity and Licorice cause Hypertension.
Prolong chewing on gum may result in pain in facial muscles
and earache in children.
Chewing gum have been shown to adhere to different degrees
to enamel dentures and fillers.
Chlorhexidine oromucosal application is limited to short term
use because of its unpleasant taste and staining properties to
teeth and tongue.
Nowadays more and more disease can be treated with NDDS.
Generally it takes time for a new drug delivery system to
establish itself in the market.
But MCG is believed to manifest its position as a convenient
and advantageous drug delivery system as it meets the high
quality standards of Pharm.Industry and can be formulated to
obtain different release profiles of active substances.
In the future we may see that more and more drugs formulated
into chewing gum in preference to other delivery systems.
The reason is simple that the chewing gum delivery system is
convenient , easy to administer anywhere, anytime and its
pleasant taste increases the product acceptability and patient
Finally it is concluded that chewing is an excellent drug
delivery system for self medication and having its own merits.
So in forth coming years it will be a much more common and
popular drug delivery system.
1. A review article published on Journal of Applied
Pharmaceutical Science 02 (06); 2012: 40-54.
2. Modified-Release Drug Delivery Technology by Michael
and Jonathan, Vol-126, page-419.
3. Journal of Pharmacy Research 2011,4(3),848-851.
4. Archives of Applied Science Research, 2010, 2 (2): 79-99.
5. IJPRD, 2011; Vol 4(03): May-2012(001-016).
7. International Journal of Research in Pharmaceutical and
Biomedical Sciences ISSN: 2229-3701.
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