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SADI: Semantic Support for Automated Workflow GenerationThe SADI Taverna plugin and SHARE Presentation to Workflow track ISoLA 2010, Crete, October 2010
Web ServicesXML + XML SchemaSemantic WebRDF + OWL
Web ServicesPOST of SOAP-XMLSemantic WebGET of RDF-XML
Web ServicesNo (rigorous) semanticsSemantic WebRich, flexible semantics
Web Services&Semantic WebFundamentally and deeply different Web technologies!
How can we make them work together?
Semantic Automated Discovery and Integrationhttp://sadiframework.org MicrosoftResearch Founding partner
SADI“best-practices” for Semantic Web Service provision
standards-compliant
Lightweight(only 2 “rules”)
What [most] bioinformatics Web Services do HTTP   POST RESPONSE
Bioinformatics web services implicitlycreate RDF “triples”
SADI “rule” #1 Make the implicit explicit… A Web Service should create RDF “triples” linking input and output data, thus explicitly describing the semantic relationship between them Input and output structuresdescribed by OWL Classes
SADI Rule #2 (Simple derivation from rule #1) The URI of the inputmust be preserved in the output Therefore, the output is explicitly about the input
Consequence The “Semantics” of our  interaction with the Web Service are now explicit
Consequence “Semantics” of HTTP POST are identical to the “Semantics” of HTTP GET Therefore SADI Web Services  behave like the Semantic Web
IMPORTANT!! SADI concerns itself ONLY with the way Web Services themselves are modeled SADI is not competitive with nor incompatible with* existing Web Service description standards (OWL-S, WSDL2, etc.) * AFAIK
Taverna A workbench for designing and executingScientific Workflows
Load-up your data and press “play”!
SADI Plug-in to Taverna
KEGG_Pathway KEGG Record hasPathwayGene
Initialize Semantic Search...
Connect your desired service to the workflow
Lather, Rinse, Repeat
And so on Und so weiter
Because we’re generating RDFthe output data is often in the form of a URI
And these URIs are “Live”
SADI-Taverna Summary Search for the property of the data you desire Automatically adds the service correctly connected automatically Unlike earlier BioMobyplugin, the SADI plugin handles parsing into and out of RDF format automatically and transparently Easy to connect SADI with non-SADI services
SHARESemantic Health And Research Environment SPARQL enhanced by SADI
A  Novel SPARQL Query Engine Uses SADI to automatically construct a workflow that creates a query-specific database
Show me the latest Blood Urea Nitrogen and Creatinine levelsof patients who appear to be rejecting their transplants PREFIX rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#>  PREFIX patient: <http://sadiframework.org/ontologies/patients.owl#>  PREFIX l: <http://sadiframework.org/ontologies/predicates.owl#>  SELECT ?patient ?bun ?creat FROM <http://sadiframework.org/ontologies/patients.rdf> WHERE { 	?patientrdf:typepatient:LikelyRejecter . 	?patient l:latestBUN ?bun .  	?patient l:latestCreatinine ?creat .  }
Likely Rejecter: A patient who has creatinine levelsthat are increasing over time - - Wilkinson MD
Likely Rejecter: …but there is no “likely rejecter” column or table in our database… only blood chemistry measurementsat various time-points
?
The definition of a LikelyRejecter is encoded in a machine-readable document  written in the OWL language  (“Ontology”) “the regression line over creatinine measurements should have an increasing slope”
The machine continues to burrow down through the definition and discovers that regression lines have things like slopes and intercepts, etc…
Then…  Two magical events occur…
The machine figures out by itselfthe need to do a Linear Regression analysisin order to answer your question
The machine figures out by itselfhow and wherethat analysiscan be doneand does it automatically!
http://www.impactlab.net/2009/03/22/improve-your-brain-power/
The SHARE system utilizes SADI to discover analytical services on the Web that do linear regression analysis
VOILA!
SHARE Summary SADI -enabled fully automated workflow generationin the context of creating a database capable of answering A SPARQL query Data  absent from local data-store automatically determined to be neededand the necessary workflow automatically constructed
Join us! SADI and CardioSHARE are Open-Source projects Come join us – we’re having a lot of fun!! http://sadiframework.org
 Credits Benjamin VanderValk(SHARE & SADI) Luke McCarthy (SADI, SHARE, Taverna, CardioSHARE) SoroushSamadian(CardioSHARE) David Withers(Taverna) Edward Kawas(SADI Service auto-generator)
U of New Brunswick Dr. Chris BakerAlexandreRiazanov Carleton University Dr. Michel Dumontier 	Marc-Alexandre Nolin 	Leonid Chepelev 	Steve Etlinger NichaellaKieth 	Jose Cruz
Microsoft Research
Fin This presentation available on SlideShare:  keywords   ‘wilkinson’   ‘ISoLA2010’

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