This document discusses applying insights from neuroscience to drive change and promote learning. It notes that the human brain is hardwired to focus on interactions and exchanges with others. While the brain retains neuroplasticity as adults, it is also programmed to conserve energy and minimize new information. The prefrontal cortex thinks best when stress and ambiguity are low. However, modern life often conflicts with how the brain is wired, exposing it to more stress, uncertainty, and information overload. To promote brain fitness and learning, organizations should minimize stress, foster inclusion and curiosity through questions, and leverage what engages the brain like pictures, patterns, and a sense of belonging.