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An introduction about DMT, its chemical structure, mode of action, effects and much more.
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  1. 1. DMT (The spirit molecule)
  2. 2. Introduction History Laws ReligionsMechanism Cases Conclusion
  3. 3. Introduction
  4. 4. • DMT or 'Di-methyl tryptamine' ,is a chemical compound that is found in mammilian brain in the part called the Pineal Gland • Also can found naturally in plants &The most common source is the root bark of Mimosa Hostilis .
  5. 5. In Drug Form ,, – DMT is the common name for the hallucinogenic drug. – DMT is inactive orally without the aid of an MAOI drug as the enzyme ''mono amine-oxidase'' oxidizes orally- taken DMT too quickly for any effect to be noticed .
  6. 6. Why is this important? • DMT is the chemical that elicits dreams. • DMT plays an important role in the process of thought, near-death experiences, as well as meditation.
  7. 7. • When smoked, injected, or ingested in combination with a (MAOI), DMT induces an intense cinegonicullah dnaetats ciledehcysp. ..
  8. 8. History
  9. 9. •DMT was first synthesized in 1931 by Richard Manske in the great wave of chemical experimentation that followed the discovery of mescaline at the end of the nineteenth century. •At this time neither its effect on the human consciousness nor its presence in traditional South American indigenous admixtures were known, and so DMT was forgotten until the snuffs and potions of the South American shamans became of great curiosity to the then burgeoning field of 'psychopharmacology‘ fifteen years later.
  10. 10. •O. Goncalves first isolated DMT from Mimosa Hostilis (= M. teniflora) in 1946 and further investigations into the plants used by South American shamans resulted in DMT being later isolated from both Piptadenia macrocarpa (= Anadenanthera colubrine var Cebil) and P. Peregrina (= A. peregrina) in 1955. •The psychoactive effects of DMT were not discovered until first reported by Stephen Szára in 1956.
  11. 11. •From January 1971 journal article by Alexander T. Shulgin, as reproduced on Deoxy, retrieved on October 13, 2012 •DMT was first synthesized in 1931, and demonstrated to be hallucinogenic in 1956. •It has been shown to be present in many plant genera (Acacia, Anandenanthera, Mimosa, Piptadenia, Virola) and is a major component of several hallucinogenic snuffs (cohoba, parica, yopo). •It is also present in the intoxicating beverage "ayahuasca" made from Banisteriopsis caapi, and it may have oral effectiveness due to the presence of several naturally occurring inhibitors of catabolic deamination.“.
  12. 12. Laws
  13. 13. •Extracted DMT (e.g. in fumarate or freebase form) is considered illegal in all the UN- bound countries. •Natural materials containing DMT (e.g., Psychotria viridis) are frequently in a legal grey area, and its control will depend on country’s current specific legislation and priorities.
  14. 14. Religions
  15. 15. •The rightness or wrongness of any action/substance/food is decided by estimating its beneficence, or its benefits to risks ratio. •Benefits of DMT: 1-Entering parallel realms of existence 2-Provides a spiritual experience and helps in exploring our inner selves 3-interactions with higher entities that aren't present in our 3D plane 3-The brain chemistry changes so that the brain recieves different types of information and that promotes creativity and the individual becomes "enlightened 4- Has a potential for psychotherapeutic use, and for helping drug addicts kick their habit
  16. 16. •Risks of DMT: Effects of high doses of DMT are toxic to the human system include: 1- Cardiac arrest ,Heart failure, coma Nerve damage. 2- Difficulty speaking or communicating 3- Sense of suspended time 4- Alternating feelings of motor paralysis and motor hyperactivity. 5- Loss decreased appetite. 6- Loss of sexual desire. 7- Frightening trips and flashbacks distortion of sensory perceptions. 8- Mental or psychological episodes.
  17. 17. Islam Christianity Judaism
  18. 18. Mechanism
  19. 19. •DMT belongs to tryptamines, which are a specific class of chemicals. •Some tryptamines are vital parts of your normal brain function such as serotonin and melatonin; others are psychedelic drugs such as LSD. •Most psychedelics produce their primary effects through a complex (non-typical) agnostic effect on the serotonin receptors 5-HT2A, 5-HT2C and 5-HT1A. •Many psychedelics also have affinity for a large number of other receptors.
  20. 20. • Tryptamine psychedelics influence a large number of brain areas, including but not limited to: – The posterior cingulate cortex (PCC) – The thalamus – The visual cortex •The primary effects of interest of the psychedelic tryptamines are on the central nervous system (CNS). There may also be effects on the peripheral nervous system (PNS) through activation of serotonin receptors in the intestinal wall for example, but these are generally mild and not (yet) medically interesting/useful.
  21. 21. • As described there is a plethora of different areas altered by the effects of tryptamines within the brain. • It is important to note that due to legal concerns, it was very difficult to perform research relating to psychedelics. As such, most research is either ‘very old ; or very recent and therefore representing ‘work in progress’ that is subject to frequent change in our understanding. Inside the Brain
  22. 22. • The most popular view of the effects of psychedelic substances is that of visual distortions and hallucinations, so we will begin there. • The visual cortex is – like all cortex – made up of many folds and shapes. As it happens however, the image seen by the eyes can be directly mapped to this cortex (reversed and flipped) if you were to physically unfold this area to a flat surface.
  23. 23. • The most consistent reported visual of psychedelic substances is that of specific patterns appearing ‘overlaid’ over normal reality. It appears that these patterns are caused by a kind of ‘data bleed’ in the visual cortex, prior to optic radiation passing the data to the conscious mind. • The patterns seen on psychedelics can be mathematically generated by computationally creating a coordinate map of this area of the brain, ‘bleeding’ data to physically nearby locations (that may not be visually nearby) and then ‘unfolding’ the cortex.
  24. 24. • Another common experience with psychedelics is the feeling that one is ‘taking in a lot more information’. • One of the jobs of the thalamus is to organise or translate the data in a way that other parts of the brain will understand. When doing this it has the additional function of acting somewhat like a filter.
  25. 25. • Under the influence of psychedelics, the thalamus reduces its activities significantly , so when you take a psychedelic substance,–you open yourself up to the opportunity to process a much greater amount of the raw sensory data, even if it is sometimes more unstructured and difficult to focus on just one thing.
  26. 26. Visions from Beyond
  27. 27. • Yet another experience common to psychedelic experiences is that of ‘receiving visions’. These are often taken as mystical revelation from another realm or world by traditional shamanic use of psychedelics in their rituals. • In contrast to the visual distortions, these visions are not generated on the visual cortex. They are more in line with dreaming whilst awake.
  28. 28. • Disrupting connectivity of the posterior cingulate cortex (PCC) through electrical stimulation causing ‘waking dreams’ not dissimilar to that aspect of the psychedelic state. • PCC cerebral blood flow is lower during REM sleep, and as a direct result of tryptamine psychedelics, showing a likely cause of these same effects when taking a psychedelic.
  29. 29. :Oneness with the Universe • Another common reported experience with psychedelic substances is that of undergoing a mystical experience. The person experiences a sense of “oneness with the universe”. • PCC is also an important ‘hub’ of information transfer. One aspect of this is separation of the self and the external world. It occurs as a part of a network based on asynchronous activity with other areas of the brain – the “default mode network” (DMN).
  30. 30. • When this is disrupted, the experiences described are the conscious mind’s attempt to make sense of the situation. • This can be interpreted as a complete breakdown of the DMN, so that the ‘self’ no longer exists until function is regained.
  31. 31. • The principal physiological effects of DMT-ingestion include an increased heart rate, increased blood pressure, strong dilation of the pupils, and steady breathing. The user will appear to be in a trance.
  32. 32. Cases
  33. 33. *Note:- These cases are not formal documented cases at the government. But it is an interview between a journalist called John Barclay works at Washington post and the cases.
  34. 34. 1) Oren:- That was the most intense thing ever. The whole room was dancing. To my left all I saw was fantasy. I was going through something very serious. You’re beyond consciousness—but you are consciousness—and you want nothing to tie you down to this physical realm. 2) Lex: It’s hard to talk about it. My concentration was very high as well as I taking the drug. But my intense becomes high and high until you’re not high anymore. I heard a kind of music. I was so dizzy.
  35. 35. 3-Adam: It hit really fast. After the second puff there were like clouds everywhere. I felt really physically heavy and time slowed down. I went through so many dreams and so many scenarios. It was basically a concentrated dream. I was awake but I couldn’t make the dream stop. 4-Victor: I felt tingly and I had a body high or whatever and I still felt self-conscious. I don’t think I lost sight of myself enough to think that wasn’t funny. Almost the strangest part is how quickly you come down. At the next day you feel weird. With this you pretty much feel normal almost immediately afterwards.
  36. 36. Conclusion
  37. 37. •N,N-Dimethyltryptamine DMT or N,N-DMT) is a psychdelic compound of the tryptamine family. •It is a structural analog of seretonin and melatonin and a functional analog of other psychedelic tryptamines. • DMT is the most powerful psychedelic drug.
  38. 38. Routes of administration 1-Inhalation: this is inhaled in a few successive breaths. The effects last for a short period of time 2-Injection: Injected DMT produces an experience that is similar to inhalation in duration, intensity, and characteristics 3-Oral ingestion: DMT is broken down by the enzyme monoamine oxidase through a process called deamination.
  39. 39. *Mechanism *Cases *Religions
  40. 40. Thank You