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• DMT or 'Di-methyl
tryptamine' ,is a chemical
compound that is found in
mammilian brain in the
part called the Pineal
• Also can found naturally in
plants &The most common
source is the root bark of
Mimosa Hostilis .
In Drug Form ,,
– DMT is the common name
for the hallucinogenic drug.
– DMT is inactive orally without the aid of an MAOI drug
as the enzyme ''mono amine-oxidase'' oxidizes orally-
taken DMT too quickly for any effect to be noticed .
Why is this important?
• DMT is the chemical that elicits dreams.
• DMT plays an important role in the process of
thought, near-death experiences, as well as
• When smoked, injected, or ingested in
combination with a (MAOI), DMT
induces an intense cinegonicullah
dnaetats ciledehcysp. ..
•DMT was first synthesized in 1931 by
Richard Manske in the great wave of
chemical experimentation that followed the
discovery of mescaline at the end of the
•At this time neither its effect on the
human consciousness nor its presence in
traditional South American indigenous
admixtures were known, and so DMT was
forgotten until the snuffs and potions of
the South American shamans became of
great curiosity to the then burgeoning field
of 'psychopharmacology‘ fifteen years later.
•O. Goncalves first isolated DMT from
Mimosa Hostilis (= M. teniflora) in
1946 and further investigations into
the plants used by South American
shamans resulted in DMT being later
isolated from both Piptadenia
macrocarpa (= Anadenanthera
colubrine var Cebil) and P. Peregrina (=
A. peregrina) in 1955.
•The psychoactive effects of DMT were
not discovered until first reported by
Stephen Szára in 1956.
•From January 1971 journal article by Alexander T. Shulgin, as
reproduced on Deoxy, retrieved on October 13, 2012
•DMT was first synthesized in 1931, and demonstrated to be
hallucinogenic in 1956.
•It has been shown to be present in many plant genera (Acacia,
Anandenanthera, Mimosa, Piptadenia, Virola) and is a major
component of several hallucinogenic snuffs (cohoba, parica, yopo).
•It is also present in the intoxicating beverage "ayahuasca" made from
Banisteriopsis caapi, and it may have oral effectiveness due to the
presence of several naturally occurring inhibitors of catabolic
•Extracted DMT (e.g. in
fumarate or freebase form) is
considered illegal in all the UN-
•Natural materials containing
DMT (e.g., Psychotria viridis)
are frequently in a legal grey
area, and its control will depend
on country’s current specific
legislation and priorities.
•The rightness or wrongness of any action/substance/food is decided by
estimating its beneficence, or its benefits to risks ratio.
•Benefits of DMT:
1-Entering parallel realms of existence
2-Provides a spiritual experience and helps in exploring our inner
selves 3-interactions with higher entities that aren't present in our 3D
3-The brain chemistry changes so that the brain recieves different
types of information and that promotes creativity and the individual
4- Has a potential for psychotherapeutic use, and for helping drug
addicts kick their habit
•Risks of DMT:
Effects of high doses of DMT are toxic to the human system
1- Cardiac arrest ,Heart failure, coma Nerve damage.
2- Difficulty speaking or communicating
3- Sense of suspended time
4- Alternating feelings of motor paralysis and motor
5- Loss decreased appetite.
6- Loss of sexual desire.
7- Frightening trips and flashbacks distortion of sensory
8- Mental or psychological episodes.
•DMT belongs to tryptamines, which are a specific
class of chemicals.
•Some tryptamines are vital parts of your normal
brain function such as serotonin and melatonin;
others are psychedelic drugs such as LSD.
•Most psychedelics produce their primary effects
through a complex (non-typical) agnostic effect on
the serotonin receptors 5-HT2A, 5-HT2C and 5-HT1A.
•Many psychedelics also have affinity for a large
number of other receptors.
• Tryptamine psychedelics influence a large
number of brain areas, including but not
– The posterior cingulate cortex (PCC)
– The thalamus
– The visual cortex
•The primary effects of interest of the
psychedelic tryptamines are on the central
nervous system (CNS). There may also be
effects on the peripheral nervous system (PNS)
through activation of serotonin receptors in the
intestinal wall for example, but these are
generally mild and not (yet) medically
• As described there is a plethora of
different areas altered by the effects of
tryptamines within the brain.
• It is important to note that due to legal
was very difficult to perform research
relating to psychedelics. As such, most
either ‘very old ; or very recent
and therefore representing ‘work in
is subject to frequent change in our
Inside the Brain
• The most popular view of the effects
of psychedelic substances is that of
visual distortions and hallucinations,
so we will begin there.
• The visual cortex is – like all cortex –
made up of many folds and shapes.
As it happens however, the image
seen by the eyes can be directly
mapped to this cortex (reversed and
flipped) if you were to physically
unfold this area to a flat surface.
• The most consistent reported visual of psychedelic substances is that
of specific patterns appearing ‘overlaid’ over normal reality. It appears
that these patterns are caused by a kind of ‘data bleed’ in the visual
cortex, prior to optic radiation passing the data to the conscious mind.
• The patterns seen on psychedelics can be mathematically generated by
computationally creating a coordinate map of this area of the brain,
‘bleeding’ data to physically nearby locations (that may not be visually
nearby) and then ‘unfolding’ the cortex.
• Another common experience with psychedelics is the
feeling that one is ‘taking in a lot more information’.
• One of the jobs of the thalamus is to organise or translate
the data in a way that other parts of the brain will
understand. When doing this it has the additional function
of acting somewhat like a filter.
• Under the influence of psychedelics, the thalamus reduces
its activities significantly , so when you take a psychedelic
substance,–you open yourself up to the opportunity to
process a much greater amount of the raw sensory
data, even if it is sometimes more unstructured and difficult
to focus on just one thing.
• Yet another experience common to psychedelic
experiences is that of ‘receiving visions’. These are often
taken as mystical revelation from another realm or world
by traditional shamanic use of psychedelics in their
• In contrast to the visual distortions, these visions are not
generated on the visual cortex. They are more in line
with dreaming whilst awake.
• Disrupting connectivity of the posterior cingulate
cortex (PCC) through electrical stimulation causing
‘waking dreams’ not dissimilar to that aspect of the
• PCC cerebral blood flow is lower during REM sleep,
and as a direct result of tryptamine psychedelics,
showing a likely cause of these same effects when
taking a psychedelic.
:Oneness with the Universe
• Another common reported experience with
psychedelic substances is that of undergoing a
mystical experience. The person experiences a
sense of “oneness with the universe”.
• PCC is also an important ‘hub’ of information
transfer. One aspect of this is separation of the self
and the external world. It occurs as a part of a
network based on asynchronous activity with other
areas of the brain – the “default mode network”
• When this is disrupted, the
experiences described are
the conscious mind’s
attempt to make sense of
• This can be interpreted as a
complete breakdown of the
DMN, so that the ‘self’ no
longer exists until function
• The principal physiological effects of DMT-ingestion
include an increased heart rate, increased blood
pressure, strong dilation of the pupils, and steady
breathing. The user will appear to be in a trance.
These cases are not formal documented cases
at the government. But it is an interview
between a journalist called John Barclay works
at Washington post and the cases.
That was the most intense thing ever.
The whole room was dancing. To my
left all I saw was fantasy. I was going
through something very serious.
You’re beyond consciousness—but
you are consciousness—and you want
nothing to tie you down to this
It’s hard to talk about it. My
concentration was very high as well as
I taking the drug. But my intense
becomes high and high until you’re
not high anymore. I heard a kind of
music. I was so dizzy.
It hit really fast. After the second puff
there were like clouds everywhere. I
felt really physically heavy and time
slowed down. I went through so many
dreams and so many scenarios. It was
basically a concentrated dream. I was
awake but I couldn’t make the dream
I felt tingly and I had a body high or
whatever and I still felt self-conscious. I
don’t think I lost sight of myself enough to
think that wasn’t funny. Almost the
strangest part is how quickly you come
down. At the next day you feel weird. With
this you pretty much feel normal almost
DMT or N,N-DMT) is a psychdelic
compound of the tryptamine
•It is a structural analog of seretonin
and melatonin and a functional analog
of other psychedelic tryptamines.
• DMT is the most powerful
Routes of administration
this is inhaled in a few successive breaths. The effects last for
a short period of time
Injected DMT produces an experience that is similar to
inhalation in duration, intensity, and characteristics
DMT is broken down by the enzyme monoamine oxidase
through a process called deamination.