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Mitosis,[object Object],Why do cells need to divide?,[object Object]
Mitosis part 1
Recap…,[object Object],Cell theory…,[object Object],Cells are the basic structural unit of life,[object Object],Cells are the functional units of life,[object Object],Cells come from pre-existing cells,[object Object]
Overview,[object Object],Why do cells need to divide?,[object Object],Repair, growth, development,[object Object],Types of reproduction,[object Object],Sexual,[object Object],Genetically different,[object Object],2 parents,[object Object],Takes time to develop, better chance of survival ,[object Object],asexual,[object Object],Genetically identical,[object Object],One parent,[object Object],Many offspring very quickly,[object Object]
DNA,[object Object],Blueprint of life, nucleic acid,[object Object],Chromatin,[object Object],Granular genetic material, spread out in nucleus of non-dividing cells,[object Object],Chromosomes,[object Object],Condensed genetic material, in dividing cells,[object Object],Sister chromatids,[object Object],Identical copies of Chromosomes joined by a centromere (“centro-” middle),[object Object]
Mitosis part 1
Mitosis part 1
Humans,[object Object],46 chromosomes ,[object Object],46 sister chromatids,[object Object],One from your mom, one from your dad,[object Object]
Cell Cycle: Life of a Cell,[object Object]
Cell Cycle,[object Object],Interphase,[object Object],90 % of cell’s life, non dividing,[object Object],G1 phase,[object Object],Grows, makes organelles,[object Object],S phase,[object Object],DNA Synthesis…DNA replicates,[object Object],G2 phase,[object Object],Cell prepares to divide, makes sure it has all important organelles for division,[object Object],M phase,[object Object],When the cytoplasm and nucleus of the cell divides,[object Object]
Cell Cycle,[object Object],There are check points in G1, S, and G2,[object Object],Make sure cell is ready to move onto the next phase (has all necessary organelles, copied DNA, etc.),[object Object],Once the cell has past the G1 checkpoint, it will complete the cell cycle,[object Object],Some cells stay in the G1 phase all their life (muscle cell, brain cells),[object Object]
Regulators of Cell Cycle,[object Object],Cyclins,[object Object],Protein that regulates the timing of the cell cycle in eukaryotic cells,[object Object],Levels of cyclins rise and fall throughout the cell cycle,[object Object],Cyclin-dependent Kinases (cdks),[object Object],Enzymes that are activated when they bind with cyclin and they make the cell cycle continue,[object Object]
Mitosis part 1
Regulators,[object Object],Internal,[object Object],Factors within the cell that control cell cycle,[object Object],Cyclin and CDKs,[object Object],Allow cell cycle to proceed only when certain processes have occurred,[object Object],Replication of chromosomes,[object Object],Chromosome Attachment to spindle before anaphase ,[object Object],External,[object Object],Factors Outside the cell,[object Object],Growth factorsmolecules that bind to cell surface that signal cell to divide,[object Object],Similar cells have molecules that have opposite effect so that when it becomes to crowded, cells stop dividing,[object Object]
Mitosis part 1
Mitosis part 1
Mitosis part 1
Mitosis part 1
M-phase,[object Object],Consists of mitosis and cytokinesis,[object Object],Mitosis,[object Object],Process by which the nucleus of a cell divides,[object Object],One parent cell makes two identical daughter cells,[object Object],This is how organisms repair tissue and grow and develop,[object Object],Cytokinesis-division of the cytoplasm,[object Object]
Depending on cell type…,[object Object],Mitosis can take a few minutes or a few days,[object Object],Muscle cells (non-dividing),[object Object],Nerve cells (non-dividing),[object Object],Skin cells (divide all the time),[object Object],Digestive Tract cells (divide all the time),[object Object]
Life Span of Some Human Cells,[object Object]
Easy way to remember M-Phase,[object Object],PMAT ,[object Object],Pilates Make Annie Toned,[object Object],Practice Makes Athletes Train,[object Object],Prophase,[object Object],Metaphase,[object Object],Anaphase,[object Object],Telophase,[object Object]
Prophase,[object Object],50-60% of time,[object Object],Chromosomes become visible,[object Object],Centrioles develop in cytoplasm near nuclear envelope,[object Object],Centrioles separate and migrate to opposite ends of nuc. Env.,[object Object],Centrosome,[object Object],Region where Centrioles are found,[object Object],Organize the “spindle”,[object Object],Fan like microtubule structure that helps separate chromosomes,[object Object],Plants do NOT have Centrioles,[object Object]
Mitosis part 1
Mitosis part 1
End of prophase,[object Object],Chromosomes coil together tightly,[object Object],Nucleolus disappears,[object Object],Nuclear envelope breaks down,[object Object]
Metaphase,[object Object],Few minutes,[object Object],Chromosomes line up in middle (M in metaphase MIDDLE),[object Object],Microtubules connect centromere of each chromosome to the 2 poles of spindle,[object Object]
Mitosis part 1
Mitosis part 1
Mitosis part 1
Anaphase,[object Object],Centromeres joining sister chromatids separate and become individual chromosomes,[object Object],They are dragged by fibers to opposite poles,[object Object],Ends when chromosomes stop moving,[object Object]
Mitosis part 1
Mitosis part 1
Mitosis part 1
Telophase,[object Object],Opposite of prophase,[object Object],Condensed chromosomes disperse into tangle of material,[object Object],Nuclear envelope reforms,[object Object],Spindle breaks apart,[object Object],Nucleolus becomes visible,[object Object],At the end 2 identical nuclei in one cell,[object Object]
Mitosis part 1
Mitosis part 1
Mitosis part 1
Cytokinesis,[object Object],Happens at the same time as Telophase,[object Object],Division of cytoplasm,[object Object],Animal Cells,[object Object],Cell membrane drawn inward until it pinches off and forms 2 id daughter cells,[object Object],Plant Cells,[object Object],Cell plate forms between nuclei,[object Object],Cell Plate develops into separate membrane ,[object Object],Cell wall appears,[object Object]
Mitosis part 1
Mitosis part 1
Mitosis part 1
Mitosis part 1
Mitosis part 1
Regulators of Cell Cycle,[object Object],Cyclins,[object Object],Protein that regulates the timing of the cell cycle in eukaryotic cells,[object Object],Levels of cyclins rise and fall throughout the cell cycle,[object Object],Cyclin-dependent Kinases (cdks),[object Object],Enzymes that are activated when they bind with cyclin and they make the cell cycle continue,[object Object]
Regulators,[object Object],Internal,[object Object],Factors within the cell that control cell cycle,[object Object],Cyclin and CDKs,[object Object],Allow cell cycle to proceed only when certain processes have occurred,[object Object],Replication of chromosomes,[object Object],Chromosome Attachment to spindle before anaphase ,[object Object],External,[object Object],Factors Outside the cell,[object Object],Growth factorsmolecules that bind to cell surface that signal cell to divide,[object Object],Similar cells have molecules that have opposite effect so that when it becomes to crowded, cells stop dividing,[object Object]

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Mitosis part 1

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