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Hypothermia Treatment For Hypoxic Ischaemic Encaphalopathy In Newborn Infants

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Hypothermia Treatment For Hypoxic Ischaemic Encaphalopathy In Newborn Infants

  1. 1. Hypothermia Therapy for Hypoxic Ischemic Encephalopathy By Ben Savage
  2. 2. Objectives  What is Hypoxic Ischemic Encephalopathy  Stages Of HIE  Antepartum Risk factors  Effects of HIE  Hypothermia Therapy  Methods  Evidence  The Future
  3. 3. What is Hypoxic Ischemic Encephalopathy (HIE)  Condition that can occur in newborn  Is caused by hypoperfusion and therefore hypoxia in the brain (Menezes et al, 2006)  Lack of oxygen leads to damage to the cell and free radical formation (Shalak et al, 2004)  Cell function is restored but cerebral energy failure recurs after 6-48 hrs (Shalak et al, 2004)
  4. 4. What is Hypoxic Ischemic Encephalopathy (HIE)  Mitochondrial dysfunction, apoptosis and cytotoxic oedema cause this delayed damage (Shalak et al, 2004)  The most active cells in the brain are the most affected. In term babies this is in the grey matter (Triulzi et al 2006)  It is associated with a high level of morbidity and mortality.
  5. 5. Progression of illness (GUNN, 2007)
  6. 6. Stages Of HIE (Anon(a), 2009)
  7. 7. Antepartum Risk factors (Menezes et al, 2006)  Maternal diabetes  Pregnancy-induced hypertension  IUGR  Maternal hypotension/shock  Severe bleeding  Placental insufficiency  Cord prolapse  Abruptio placentae  Dystocia
  8. 8. Effects of HIE  Neurodevelopment problems and disability  Cerebral palsy  Seizures  Death
  9. 9. Hypothermia Therapy
  10. 10. (Anon (b), 2009)
  11. 11. Hypothermia (Shalak et al, 2004)  The hypothermia treatment is targeted at reducing the damage caused by the second stage  It reduces energy requirements and therefore the levels of free radicals  Preserves antioxidants  Inhibits apoptosis
  12. 12. Entry Criteria (Azzopardi et al, 2009)  36wks or greater gestation, age >6hrs  Any of:  APGAR 10mins 5 or less  Continued need for resuscitation 10mins  Within 60mins birth acidosis,  pH <7.00/ base deficit >16mmol/L  Moderate to severe encephalopathy  Abnormal background activity of at least 30mins or seizures on aEEG  Exclusion if there is a major congenital abnormality that requires immediate surgical correction
  13. 13. Methods  To cool the babies there are two options  Cool Cap – the only part of the body actively cooled is the head  Total body cooling
  14. 14. Method (Azzopardi et al 2009)  Treatment needs to begin before 6 hours after birth, before the 2nd stage is entered  Baby is rapidly cooled to 33-34°C and continuously monitored  They are kept cooled for 72 hours  Gradually re-warmed at no rate greater than 0.5°C per hour, to a maximum of 37±0.2°C
  15. 15. Evidence Base  There have been several trials and a cochrane review looking at the effectiveness of treatment.  The cochrane review looked at various outcomes. One of these was the difference between the two cooling methods. (Jacobs et al 2007)
  16. 16. (Jacobs et al 2007)
  17. 17. Cochrane Review (Jacobs et al 2007)  This review showed:  Selective head cooling has no statistically significant effect on mortality or severe disability  Whole body cooling causes a statistically significant reduction in mortality and severe disability.  Hypothermia therapy reduces mortality and major disability
  18. 18. TOBY trial 2009 (Azzopardi et al, 2009)  Multi centre RCT.  325 infants randomised to intensive care with cooling or intensive care alone  Babies cooled to 33-34 °C for 72hrs then slowly re-warmed
  19. 19. TOBY trial 2009 (Azzopardi et al, 2009)
  20. 20. TOBY trial 2009 (Azzopardi et al, 2009)  Conclusion:  No significantly reduction in the combined rate of death or severe disability  Improved neurological outcomes in survivors
  21. 21. Summary  HIE is a serious condition that can have implications for the survival and development of the child  Hypothermia therapy used to reduce effect of 2nd phase cell damage  Treatment using total body cooling is most effective
  22. 22. The Future  Is this method cost effective  TOBY study current looking at this.  National guidelines, only currently consultation document  NICE (2010)  Whether this would be suitable for perterm or surgical babies
  23. 23. Reflection  Why I picked this topic  What have I learnt
  24. 24. References  Anon(a) to_Cooling.htm, 10/11/09  Anon (b) 10/11/09  Denis V. Azzopardi et al, Moderate Hypothermia to Treat Perinatal Asphyxial Encephalopathy, New England Journal of Medicine October, 2009, 361;14  ALISTAIR JAN GUNN & PETER D. GLUCKMAN, Head Cooling for Neonatal Encephalopathy: The State of the ArtCLINICAL OBSTETRICS AND GYNECOLOGY, Volume 50, Number 3, 636–651, 2007  Jacobs SE et al. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database of Systematic Reviews 2007, Issue 4. Art. No.: CD003311. DOI: 10.1002/14651858.CD003311.pub2.  Marcio Sotero de Menezes et al April 2006  Lina Shalak et al, Hypoxic–ischemic brain injury in the term infant-current concepts, Early Human Development 80 (2004) 125– 141  Triulzi et al, Patterns of damage in the mature neonatal brain Pediatric Radiology [0301-0449] Triulzi yr:2006 vol:36 iss:7 pg:608 -620
  25. 25. Thank you for listening Any Questions