3. Nephroblastomatosis
• Nephrogenic rests are foci of metanephric
blastema that persist beyond 36 weeks gestation
and have the potential for malignant
transformation into Wilms tumor.
5. Nephroblastomatosis
• It is currently believed that nephrogenic rests
give rise to approximately 30%–40% of Wilms
tumors, and they are found in up to 99% of
bilateral Wilms tumors.
7. Nephroblastomatosis
The role of imaging in evaluating patients suspected of
having nephroblastomatosis:
(a) Preoperative assessment in a patient suspected of
having Wilms tumor to exclude macroscopic NRs in the
contralateral kidney.
(b) Follow-up of patients with known micro- or macroscopic
nephroblastomatosis to detect neoplastic change.
(c) Screening of patients with syndromes associated with
nephroblastomatosis and Wilms tumor.