1. ORBAS 20, 40 mg
(Olmesartan Medoxomil INN)
Presented by
Mohammed Moshiur Rahaman
Senior Brand Executive
Brand Management Department
Strategic Brand Management Division
The ACME Laboratories Ltd.

2. ORBAS
(Olmesartan Medoxomil INN 20, 40 mg)
Olmesartan effectively reduces blood
pressure in adult patients along
with 6 years old children

3. Price & Supply
Price: 20 mg (08 taka)
40 mg (15 taka)
Supply: 3x10 tablets
Product Group : A

4. Indication
For the treatment of hypertension
Dosage & Administration
 20 mg Once daily OR
may be increased after 2 weeks to 40 mg
 Children (10 mg for weigh <35 kg &
20 mg for weigh >35 kg)

9. Endothelial Cell:
The endothelium is the thin layer of cells that lines the interior
surface of blood vessels and lymphatic vessels, forming an
interface between circulating blood in the lumen and the rest of the
vessel wall. The cells that form the endothelium are called
endothelial cells.
Major function of Endothelial Cell:
Vasoconstriction and vasodilation, and hence the control of blood
pressure.
Dysfunction of Endothelial Cell:
Endothelial dysfunction can result from and/or contribute to several
disease processes, as occurs in hypertension,
hypercholesterolemia, diabetes.

15. Product information of Losart, Valtin & Orbas
Losart Valtin Orbas
Generic Losartan Valsartan Olmesartan
Dosage form Tablet Tablet Tablet
Strength 25, 50, 100 mg 80, 160 mg 20, 40 mg
Indication Hypertension, Congestive Heart
failure
Hypertension, Heart failure, Myocardial
infarction
Hypertension
AT1 affinity 10000 fold 20000 fold 12500 fold
tmax (h), on
set of action
3-4 hrs 2 hrs 1.4-2.8 hrs
IMS market
size
105 crore with 8% positive growth 9.7 crore with 6.21% negative growth 15.56 crore with 65% positive
growth
Positioning Shows better control on blood
pressure
Provides prompt & sustained blood
pressure
More potent ARB Ensures
double digit BP reduction
Economic ARB Significantly reduces mortality and
morbidity in patients with HF
Shows 24 hrs BP control, even
final 4 hrs
Also effective in CHF Shows early onset of action
compared to other ARBs
Improves endothelial
dependent coronary dilation in
hypertensive patients
Mechanism of
action
Blocks AT1 receptor, as a result Angiotensin II is unable to participate further reaction