3 Regulation Of Cxcr4 Signaling By Najmaldin Saki (2)
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3 Regulation Of Cxcr4 Signaling By Najmaldin Saki (2)
- 1. CXCR4 & SDF1 By : Najmaldin Saki 2008
- 2. ย
- 3. ย
- 7. CCR5 NK-1R Signal Transduction? Hetero- dimerization? Protein Synthesis? CXCR4 HIV Cytokines, Chemokines, CCR5, CXCR4 NK-1R Antagonists NK-1R:CCR5 Interaction in Macrophages CD4 SP
- 9. In the other hand Inflammatory cytokinse Attenuate CXCR4 expression IL1 beta โ INF gama โ TNF Alpha HTLV1 Tax protein NRF1 HIV Herpes viruse 6 Target cell
- 11. ย
- 12. 2-Regulation of CXCR4 signaling 2.1. SDF binding CCR5 CXCR4 CD26 Cathepsin G & Neutrophil elastase Protease dipeptidase SDF Neu
- 14. SDF CXCR4 PLC- beta PI3K Src 2.2.G-protein signaling jak STAT arrestin pERK P38 PTX Desensitization Arre 2 arre3
- 16. C-tail
- 18. 2-Cancer The expression of CXCR4 has been detected in 23 different cancers of various origins and is the most common chemokine receptor expressed on cancer cells. O2 Activation (HIF1) Hypoxia inducible factor 1 CXCR4 (VHL)von hipple lindau Breast cancer VEGF metastasis NF- k B Enhanced migration and adhision of rhabdomyosarcoma Oncoprotein PAX-FKHR Enhanced the transforming ability of breast cancer cells Oncoprotein RET/PCT
- 19. Involvement of CXCR4/SDF-1 system in cancer progression Pancreatic cancer Kosshiba et al., Clin. Cancer Res. 2000 Neuroblastoma Geminder et al., J. Immunol. 2001 Breast cancer Muller et al., Nature 2001 Rhabdomyosarcoma Libura et al., Blood 2002 Prostate cancer Taichman et al., Cancer Res. 2002 Colon cancer Zeelemberg et al., Cancer Res. 2003 Osteosarcoma Perissinotto et al., Clin Cancer Res. 2005 Laverdiere et al., Clin Cancer Res. 2005 N on-small cell lung cancer cells Su et al., Clin Cancer Res. 2005 E sophageal cancer Kaifi et al., J Natl Cancer Inst. 2005 Carcinomatosis of Gastric Cancer Yasumoto et al., Cancer Res. 2006 G lioma Ehtesham et al., Oncogene 2006 Melanoma Bartolome et al., Cancer Res. 2006
- 20. Cancer cell Y Y chemokine receptor chemokine endothelium Target tissue Non-target tissue Cancer cell Y Y endothelium different chemokine
- 21. The C-tail is absolutely critical for proper regulation of CXCR4