Biotechnology is application of molecular
and cell biology tools to solve problems of
health, agricultural and the environment
The discovery of DNA structure in 1955
Biotechnology tools include cloning, genetic
modification, genetic screening
What is biotechnology?
Biotechnology can provide
Sustainable Growth, Healthy Lifestyle and
Indian biotech story began with Biocon in 1978.
Initiative in early 1980’s
Agencies - DST, CSIR, ICAR, ICMR, UGC
National Biotechnology Development Board – 1982
Department of Biotechnology – 1986
India is the first country in the world to create a separate
Department of Biotechnology (DBT) under the Ministry of
Science & Technology in 1986
Indian biotech made its presence on the world map in 1997, when
Hyderabad based Shantha Biotechnics launched the indigenously
developed hepatitis B vaccine, Shanvac.
New forms of treatment
Control of biodeposits
Bleaching of pulp
Waste water treatment
Production of chemicals
Production of enzymes
Biomaterials for medical
Modification of raw
Plant and animal
Treatment of biowaste
Food and feed
Virus-resistant crop plants and livestock
Diagnostics for detecting genetic diseases and
Therapies that use genes to cure diseases
Recombinant vaccines to prevent disease
Biotechnology can also aid the environment
"DNA analysis: be it for forensic research or for exploratory
"Food Production and ways to enhance productivity",
"New Diagnostic Equipment",
"Environment friendly products and services",
"New Apps being developed for various smart phones to probe
The future of this field is thus very bright!
TYPES OF BIOTECHNOLOGY
Recombinant, R protein, R DNA
Genetically Modified Organism (GMO)
Antibody (monoclonal antibody)
Gene therapy, Immunotherapy
Risks and advantages of biotech
Shanvac-B (r-DNA Hepatitis B Vaccine) is
India's first recombinant vaccine and is
produced in the yeast Pichia pastoris.
Hepatitis B vaccine is used for the prevention
of the deadly liver infection Hepatitis B which
can lead to liver failure or cancer.
Shanvac-B is India’s first WHO-Geneva pre-
qualified Hepatitis-B vaccine.
Bharat Biotech recently launched the world’s
first clinically proven typhoid conjugate
vaccine, Typbar – TCV, for infants above six
months and adults
PRODUCTS OF BIOTECH
A new rice based vaccine promises effective
treatment for the dreaded Cholera
Other diseases targeted for rice based
vaccines include the pesky influenza and the
much dreaded HIV
Gene-modified potato seeds would enhance
the crop’s overall resistance against blight, a
commonly found disease in potato.
Giant Strides in crop biotechnology
Tomatoes, with their abundant lycopene, may
defend against cancer by protecting DNA from
Broccoli sprouts contain an abundance of the
cancer-fighting phytochemical sulforaphane
Rich in flavonoids – apples may protect against
Garlic, with it’s abundant allicin, may lower blood
cholesterol and protect against stomach cancer
A newly uncovered mechanism for
clearing common brain blood clots
provides a potential therapeutic target for
stroke recovery and age-related cognitive
C.K. Lam et al, Nature, 2010 May 27, 465(7297): 478-82.
Eval by Jaime Garcia-Anoveros, Northwestern
University; Ray Rodgers, University Adelaide.
Brain Blood Busters
Super E. Coli
The mother cell of E. Coli maintains a constant
growth rate throughout its replicative life
(hundreds of cell divisions), despite accumulating
damage and an increased probability of death,
suggesting that growth and aging are decoupled,
unlike all other studied aging models.
P. Wang et al, Current Biology, 2010 May 26, 20:1099-1103. Eval by
Roy Kishony, Harvard Univ.; Thomas Meier, Max Planck Institute
First implantable artificial kidney could remove
demand for dialysis and donor organs
•U.S researchers have just unveiled the first
prototype model of the artificial kidney that
would be implanted inside the body and work
as well as a living organism and could eliminate
the need for dialysis.
•The kidney is being developed in a
collaborative effort by engineers, biologists and
physicians led by Dr. Shuvo Roy at the
University of California San Francisco. The
treatment has already been proven to work for
the sickest patients using a room-sized external
•The process relies on the body's blood
pressure to perform filtration without needing
pumps or an electrical power supply.
The artificial kidney will be
the size of a coffee cup.
Blood will be pumped
through microscopic filters
using the body's own blood
Scientists have successfully grown complex human
brain tissue from stem cells using a new 3D culture
system, according to a study published in the
Researchers from the Institute of Molecular
Biotechnology (IMBA) at the Austrian Academy of
Sciences (OeAW) say the newly created tissue could
be the start of developing model systems for the
About 32 percent of the global cotton cultivation area
Contributes 21 percent of the global cotton produce,
second after China.
Provides employment to around 42 million people
directly or indirectly.
Production increased more than double from 13.6
million bales in 2002-2003 to 35.5 million bales in
Over the past few years, India has even managed to
produce at least six to nine million bales more than
required for domestic consumption.
An importer country became an exporter country
Benefits of Human Genome Project
Improvements in medical prevention of disease, gene
therapies, diagnosis techniques
Production of useful protein products for use in
medicine, agriculture, bioremediation and pharmaceutical
Improved bioinformatics – using computers to help in
DNA sequencing …
Biotechnology India: The Infrastructure
Institutions & Manpower
Number of hospitals : 16,000
Number of doctors : 500,000
Number of research institutions: 200
Number of Scientists : 25,000
Medical graduates produced : 17,500 per yrs
Science graduates produced : 500,000 per yrs
Number of Agriculture Univs. : 40
Major Biotech Companies
Serum Institute of India
Krebs Biochemical's & Industries
Chiron Behring Vaccines
Eli Lilly and Company
Organizations in India working for the growth of
the biotechnology industry
Association of Biotechnology Led Enterprises (ABLE)
Association of Diagnostic Manufacturers of India
Association of Contract Research Organizations
Indian Society for Clinical Research (ISCR)
All India Crop Biotechnology Associations (AICBA)
All India Biotech Association (AIBA)
Funding Agencies in area of
APIDC Venture Capital Limited
Gujarat Venture Capital
IDBI Venture Capital
And Several Others
Biotech Knowledge Providers
Council of Scientific and Industrial Research
Indian Council of Medical Research
Indian Council of Agriculture Research
Indian Institute of Science, Bangalore
Indian Institute of Technology
Five bioclusters are emerging in the
New Delhi-Lucknow *
• Three of these clusters have already found a
place in a recent global listing of bioclusters by a
Why did a Biocluster arise in Lucknow?
Expertise of over 400 Scientists, 700 Technicians and 500
Park holding hands of 15 biotech units
Biopharma - TWO
Lifecare Innovation Pvt. Ltd.
Chandan Healthcare Pvt. Ltd.
Bio-Agri (PPP mode) - TWO
Sheel Biotech Pvt. Ltd.
Hindustan Bioenergy Ltd. - Expanded its activities in 28 acres of land at Kundanganj District, Raebareli
Bioinformatics & Bioservices – Five
Institute of Biological Sciences
ACS Informatics Pvt. Ltd.
Software Technology Parks of India
Acadia Research Lab. Pvt. Ltd.
Genetech BioLabs Private Limited
Health area (diagnostics, herbal cosmetics, nutraceuticals) – Six
India Pesticides Limited:
ABC Genomics (India) Pvt. Ltd
Amor Herbals Pvt. Ltd.
CIMAP – Point of Presence
Super Biofresh Pvt. Ltd.
SKiES Life Technologies Pvt. Ltd.-has 2 acres of land at UPSIDC Food Park