Formulation and Processing of Special Oral Dosage Forms

FORMULFORMULATION ASPECTS OF SPECIAL TABLET LIKE -BUCCAL,CHEWABLE,SUBLINGUAL TABLETS & LOZENGES (Medicated Lozenges) Presented By …Nisargrx@hotmail.co.uk

CONTENTS:- ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

INTRODUCTION:- ,[object Object],[object Object],[object Object]

DEFINITION & RELATED TERMS:- ,[object Object],[object Object]

[object Object],[object Object],[object Object]

LOZENGES/ MEDICATED LOZENGES:- ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

HARD CANDY LOZENGES:- ,[object Object],[object Object]

ASPECTS:- ,[object Object],[object Object],[object Object],[object Object]

CONTENTS OF LOZENGES:- ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Dextrose Equivalent (DE):- ,[object Object],[object Object],[object Object]

PROPERTIS & FUNCTIONAL USES OF CORN SYRUP:-

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

COOKING:- ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

COMPRESSED TABLET LOZENGES:- ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

MANUFACTURING STPES INVOLVED IN C.T.L:- ,[object Object],[object Object],[object Object],[object Object]

SUBLINGUAL DOSAGE FORM:- ,[object Object],[object Object],[object Object],[object Object],[object Object]

FORMULATION FACTORS:- ,[object Object],[object Object],[object Object],[object Object],[object Object]

MOLDED SUBLINGUAL TABLETS:- ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

HAND MOLDING & MACHINE MOLDING:- ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

COMPRESSED SUBLINGUAL TABLET:- ,[object Object],[object Object],[object Object],[object Object],[object Object]

BUCCAL TABLETS:- ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

CHEWABLE TABLETS:- ,[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

FORMULATION TECHNIQUES:- ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

MICROENCAPSULATION:- ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

ADSORPTION:- ,[object Object],[object Object],[object Object],[object Object]

ION EXCHANGE:- ,[object Object],[object Object],[object Object],[object Object],[object Object],Vitamins Coating agent %W/W Thiamine mononitrate Mono& diglycerides- 33.3 Riboflavin -Of Fatty- 33.3 Pyridoxime -acid 33.3 Niacinamide Stearic acid 33.3

SPRAY DRYING:- ,[object Object],[object Object],[object Object],[object Object]

COATING BY CONVENTIONAL GRANULATING METHOD:- ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

MATERIAL USED IN FORMULATION OF CH.TAB.:- ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

MOISTURE UPTAKE CHARACTERISTICS:- ,[object Object],[object Object],[object Object],[object Object],[object Object]

HARDNESS OF TABLET WITH DEXTROSE, MANNITOL, SUCROSE…. ,[object Object],[object Object],Vehicles Initial hardness (Sc) Hardness (sc unit) after 12 days 43%RH 65.%RH 75%RH 100%RH Lactose (Ah) 14.0 12.0 11.2 10.8 7.9 Mannitol 9.9 7.5 4.9 3.6 1.7 Sorbitol 14.7 12.2 8.1 6.4 4.2 Dextrose 15.6 11.4 6.2 4.0 1.8 Sucrose 15.1 7.2 2.3 1.2 0.2

LOADING POTENTIAL:- ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

RELATIVE SWEETNESS OF VEHICLE /AUXILLARY SWEETENER:- ,[object Object],[object Object],[object Object],[object Object]

2). FLAVORING AGENTS:- ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

RECENT DEVELOPMENT & ASPECTS CHEWING GUMS (chewable tablets):- ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object]

FORMULATION ASPECT:- ,[object Object],[object Object],[object Object],External layers % Core layer % Antiadherant layer 70-90 Active 0.1-8 Compression adj. 1-10 Gum base 70-80 Sweetener 1-10 Compr. adj. 1-10 Flavors 1-10 Sweetener 1-10 Flavors 2-20

MELT-IN-MOUTH TABLETS BY SUBLIMATION TECHNIQUE:- ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Name of Ingredients Forml n SO 1 SO 2 SO 3 Olanzapine 5.0 5.0 5.0 Pearlitol SD200 113.12 94.375 75.625 Ammo. bicarbonate - 18.750 37.500 Aspartame 3.125 3.125 3.125 Flavour 1.875 1.875 1.875 Aerosil 200 0.625 0.625 0.625 Magnesium Stearate 1.250 1.250 1.250 Formulation code Disint. Time in sec. In Oral SO 1 80 +/-5 80+/-5 SO 2 75 +/-5 60+/-5 SO 3 80 +/-5 35+/-5

MOUTH DISSOLVING TABLETS:- ,[object Object]

TECHNOLOGIES FOR PREPARING MDT:- ,[object Object],[object Object],[object Object],[object Object],[object Object]

QUIT SMOKING LOZENGES:- ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

REFERENCES:- ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Formulation and Processing of Special Oral Dosage Forms

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Formulation and Processing of Special Oral Dosage Forms