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Nuclear and isotope techniques in   nutritional researches. Pawitra Masa-at 4937092 SIRS/M February 2, 2007 SIRA 609
B .  E .  Christopher Nordin 1, , Peter D. O Loughlin, Allan G. Need ,  Michael Horowitz ,  and Howard A. Morris  Radiocalcium absorption is reduced in postmenopausal women with vertebral and  most types of peripheral fractures  10.1007 / s00198-003-1493-1 © International Osteoporosis Foundation and National Osteoporosis Foundation 2003 Osteoporosis International With other metabolic bone diseases
Introduction ,[object Object],[object Object],[object Object],[object Object],[object Object]
Introduction ,[object Object],[object Object]
Clinical material  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical material ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical method  The subject arrived  after overnight fast blood   sample was withdrawn. As blank, 1,25-(OH)2 Vit.D3 ,[object Object],[object Object],[object Object],Blood sample taken exactly  60 min later. Centrifuge. Count plasma aliquots By liquid scintillation counter
Calcium-45
Results  ,[object Object]
[object Object],Mean ~ 0.7 Mean ~ 0.51 100 % absorption 71 % absorption
[object Object],[object Object]
[object Object]
The most significant relative risks were related to  fractures of the  humerus, vertebrae, and hip .  Calcium absorption was not significantly related to  fractures of the  ankle, foot, or tibia ,  but they were also the smallest groups  Age was a significant determinant of all fractures except  those of  the tibia .
Discussion ,[object Object],[object Object]
[object Object],[object Object],Discussion
What estrogen appears to do is  to reduce the  resistance   to calcitriol  caused by estrogen deficiency calcitriol and PTH production  in responseto the increase  in bone resorption  and assumed increase  in ionized calcium(hypercalcimia)  Calcium absorption is reduced. Machanism for monitor Ca  homeostasis     secretion of PTH the increase in bone resorption  Cause of osteoporosis  in postmenopausal women
Radiocalcium absorption test Ca-45 Blood intestine T Low calcium absorption    low count rate Bone
Conclusion ,[object Object],[object Object],[object Object],[object Object]
Thank you   :)

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Isotope Techniques Reveal Reduced Calcium Absorption in Women with Bone Fractures

  • 1. Nuclear and isotope techniques in nutritional researches. Pawitra Masa-at 4937092 SIRS/M February 2, 2007 SIRA 609
  • 2. B .  E .  Christopher Nordin 1, , Peter D. O Loughlin, Allan G. Need , Michael Horowitz , and Howard A. Morris Radiocalcium absorption is reduced in postmenopausal women with vertebral and most types of peripheral fractures 10.1007 / s00198-003-1493-1 © International Osteoporosis Foundation and National Osteoporosis Foundation 2003 Osteoporosis International With other metabolic bone diseases
  • 3.
  • 4.
  • 5.
  • 6.
  • 7.
  • 9.
  • 10.
  • 11.
  • 12.
  • 13. The most significant relative risks were related to fractures of the humerus, vertebrae, and hip . Calcium absorption was not significantly related to fractures of the ankle, foot, or tibia , but they were also the smallest groups Age was a significant determinant of all fractures except those of the tibia .
  • 14.
  • 15.
  • 16. What estrogen appears to do is to reduce the resistance to calcitriol caused by estrogen deficiency calcitriol and PTH production in responseto the increase in bone resorption and assumed increase in ionized calcium(hypercalcimia) Calcium absorption is reduced. Machanism for monitor Ca homeostasis  secretion of PTH the increase in bone resorption Cause of osteoporosis in postmenopausal women
  • 17. Radiocalcium absorption test Ca-45 Blood intestine T Low calcium absorption  low count rate Bone
  • 18.
  • 19. Thank you :)