Ratziu Hépatites Nane Vhg Ttv

Hepatites Non A-E ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Evidence for Additional Hepatitis Agents ,[object Object],[object Object],[object Object],[object Object],[object Object]

VHG : GBV-C, 95 % homology VHG : HCV, 29 % homology

HGV Epidemiology and Diagnosis ,[object Object],[object Object],[object Object],[object Object],[object Object]

HGV Epidemiology and Diagnosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Prevalence of Serum HGVRNA in Acute Hepatitis of Viral Origin ,[object Object],[object Object],[object Object],[object Object],% * : p<0.05 vs HAV and HCV Alter M, NEJM 1997

HGV : is it an Hepatotropic Virus ? Pessoa, Hepatology 1998

HGV : is it an Hepatotropic Virus ? ,[object Object],[object Object],Pessoa, Hepatology 1998

HGV has no Pathogenic Role on the Course of Acute Hepatitis ,[object Object],[object Object],[object Object]

HGV and Transfusion associated Hepatitis (TAH) ,[object Object],[object Object],[object Object],[object Object],A CAUSAL RELATION BETWEEN HGV AND TAH IS NOT ESTABLISHED Alter H, NEJM 1997

HGV in End-Stage Liver Disease and Liver Transplantation ,[object Object],[object Object],[object Object],Fried, Hepatology 1997 Pessoa, Hepatology 1998

Does HGV Impact on the Course of other Viral Infections? ,[object Object],[object Object]

No Histopathologic Impact of HGV on Chronic Hepatitis C ,[object Object],[object Object],[object Object],[object Object],HGV INFECTION DOES NOT MODIFY THE COURSE OF CHRONIC HCV INFECTION CONTRIBUTION TO LIVER DISEASE LESS THAN OTHER HEPATOTROPIC VIRUSES Bralet, Gastroenterology 1997

Improved Survival in HGV-HIV Coinfection Tillmann, NEJM 2001

Improved Survival in HGV-HIV Coinfection ,[object Object],[object Object],[object Object],[object Object],[object Object],Tillmann, NEJM 2001

Multicenter AIDS Cohort Study Baltimore, Chicago, Pittsburgh, LA ,[object Object],[object Object],[object Object],[object Object],Williams, NEJM 2004

L’infection par le GBV-C Améliore la Survie des Patients VIH ,[object Object],[object Object],GBV-C pos GBV-C éliminé GBV-C neg SURVIE A 10 ANS CD4+ 75% 39% 16% -26/mm 3 -70/mm 3 -107/mm 3 Williams, NEJM 2004

Inhibition of HIV Replication by HGV in PBMC ,[object Object],[object Object],Xiang, NEJM 2001

Molecular Interactions Between GBV-C and HIV

TT Virus and Transfusion Associated Hepatitis ,[object Object],[object Object],[object Object],[object Object],Matsumoto, Hepatology 1999

TTV and Acute Viral Hepatitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],% with TTV Condition Kanda, Hepatology 1999 NO ETIOLOGIC ROLE !

Chronic TTV Carriage ,[object Object],[object Object],[object Object],[object Object],[object Object],Lefrere JJ, Blood 1999

TTV and Chronic Liver Disease ,[object Object],[object Object],[object Object],Tagger, Hepatology 1999 Kato, J Hepatol 1999 Nakano, J Hepatol 1999

TTV, Chronic Hepatitis C and Response to IFN ,[object Object],[object Object],[object Object],[object Object],TTV DOES NOT MODIFY CLINICAL FEATURES OF CHRONIC HEPATITIS C OR RESPONSE TO IFN Hagiwara, J Viral Hepat 1999

Prognostic Significance of TTV in Patients with HIV Infection ,[object Object],[object Object],[object Object],[object Object],[object Object],Shibayama, AIDS 2001 Christensen, J Inf Dis, 2000

TTV - The Essentials ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Establishing Causality for New Viruses ,[object Object],[object Object],[object Object],[object Object],[object Object],Alter, Postgraduate Course, AASLD 2000

Chronic Liver Disease - Beyond the Viruses ... ,[object Object],[object Object]

Etiologie de la Cirrhose (n=78) Etude Dionysos (Hepatology 1994) HCV 28 % HBV 9 % HBV+ ALCOOL 3 % HEMO CHROMATOSE 1 % ALCOOL 26 % CBP 1 % HCV+ ALCOOL 3% CRYPTOGENIC 24 %

Factors Associated with ALT Levels ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Piton, Hepatology 1998 Prati, Ann Intern Med 2002

What is a Normal ALT Value ? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Piton, Hepatology 1998 Prati, Ann Intern Med 2002

Clinical Implications of the Different Thresholds for Normal ALT ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Piton, Hepatology 1998 abnormal ALT

Chronic Liver Disease - Beyond the Viruses ... ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Abnormal Liver Function Tests ,[object Object],[object Object],[object Object],[object Object]

Ratziu Hépatites Nane Vhg Ttv

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Ratziu Hépatites Nane Vhg Ttv