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Tutorial #1 by Ma’ayan Fishelson Changes made by Anna Tzemach Basic Concepts  in Genetics
Genetic Information ,[object Object],[object Object],[object Object],[object Object]
Chromosome Logical Structure ,[object Object],[object Object],Locus1 Possible Alleles: A1,A2 Locus2 Possible Alleles: B1,B2,B3
Human Genome ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Genotypes  Phenotypes ,[object Object],[object Object]
  Genotypes     Phenotypes   (example)   ,[object Object],[object Object],genotypes phenotypes
Dominant vs. Recessive ,[object Object],[object Object]
One Locus Inheritance heterozygote homozygote 2 1 A | A a | a A | a 3 4 a | a A |  a 5 6 a | a Male Female
Mendel’s 1 st  Law Two members of a gene pair segregate from each other into  the gametes, so half the gametes carry one member of the  pair and the other half carry the other member of the pair. Y / y y / y ½ y/y ½ Y/y ½ y ½ Y all y Gamete production Gamete production
Calculating Probabilities ,[object Object],[object Object]
X-linked Inheritance Different results obtained from reciprocal crosses between red-eyed and white-eyed Drosophila. Explanation : The gene  responsible for eye-color  is  X-linked . Females have 2 X-chromosomes, while  males have 1 X-chromosome and 1 Y-chromosome.
Mendel’s 2 nd   Law ,[object Object],[object Object],Gene pairs on  SEPARATE CHROMOSOMES   assort independently at meiosis. This “law” is true only in some cases.
Medical Genetics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Medical Genetics (cont.) ,[object Object],[object Object],[object Object]
Medical Genetics (cont.) ,[object Object],[object Object],[object Object],[object Object]
Medical Genetics (cont.) ,[object Object],[object Object],[object Object],[object Object],[object Object]
Medical Genetics (cont.) ,[object Object],[object Object],[object Object],[object Object]
Medical Genetics (cont.) ,[object Object],[object Object],[object Object],[object Object]
Medical Genetics (cont.) ,[object Object],[object Object],[object Object],[object Object]
Question #1 1 2 ,[object Object],[object Object],[object Object]
Question #2 ,[object Object],[object Object],[object Object],[object Object]
Question #2-Solution Highlights P – the normal allele p – the mutant allele P/p P/p P/p P/p p/p p/p P/- P/-
Question #3 ,[object Object],[object Object],[object Object],[object Object],1 2 3 4 5 6 7 8 9 10
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Question #3-Solution Highlights Same All normal
Notes  ,[object Object],[object Object]
Notes ,[object Object],[object Object]
Notes -cont ,[object Object],[object Object],[object Object]
Notes -cont ,[object Object],[object Object],[object Object]

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Tutorial01 (1)

  • 1. Tutorial #1 by Ma’ayan Fishelson Changes made by Anna Tzemach Basic Concepts in Genetics
  • 2.
  • 3.
  • 4.
  • 5.
  • 6.
  • 7.
  • 8. One Locus Inheritance heterozygote homozygote 2 1 A | A a | a A | a 3 4 a | a A | a 5 6 a | a Male Female
  • 9. Mendel’s 1 st Law Two members of a gene pair segregate from each other into the gametes, so half the gametes carry one member of the pair and the other half carry the other member of the pair. Y / y y / y ½ y/y ½ Y/y ½ y ½ Y all y Gamete production Gamete production
  • 10.
  • 11. X-linked Inheritance Different results obtained from reciprocal crosses between red-eyed and white-eyed Drosophila. Explanation : The gene responsible for eye-color is X-linked . Females have 2 X-chromosomes, while males have 1 X-chromosome and 1 Y-chromosome.
  • 12.
  • 13.
  • 14.
  • 15.
  • 16.
  • 17.
  • 18.
  • 19.
  • 20.
  • 21.
  • 22. Question #2-Solution Highlights P – the normal allele p – the mutant allele P/p P/p P/p P/p p/p p/p P/- P/-
  • 23.
  • 24.
  • 25.
  • 26.
  • 27.
  • 28.

Editor's Notes

  1. References : Kenneth Lange “Mathematical and Statistical Methods for Genetic Analysis” Jurg Ott “Analysis of Human Genetic Linkage” http://www.accessexcellence.com/AB/GG/ http://www.nhgri.nih.gov/DIR/VIP/Glossary/index.html http://www.tokyo-med.ac.jp/genet/index-e.htm
  2. Image from http://www.accessexcellence.com/AB/GG/
  3. Image from http://www.accessexcellence.com/AB/GG/