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Nanotechnology:  Progress, Potential and Pitfalls Peter Hackett Executive Professor,  School of Business, University of Alberta  Fellow, National Institute for Nanotechnology [email_address]
Synthesis, Structure, and Dynamics ,[object Object],Synthesis Structure  Dynamics
The “wow” of nanotechnology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
NANOTECHNOLOGY PROGRESS
CANDU Nuclear Reactor ,[object Object],[object Object],[object Object]
Radiation Creep ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Isotope shifts in atomic spectra ,[object Object],[object Object],[object Object],[object Object]
Hyperfine coupling effects ,[object Object],[object Object],[object Object],[object Object],[object Object]
Pulsed laser metal cluster beams ,[object Object],[object Object],[object Object],[object Object]
LIF of Zirconium Atom Beams ,[object Object],RED  16296.62 cm-1  BLUE
LIS of Zirconium Atom Beams ,[object Object],Mass Spectrum m/e Excitation Wavelength
Molecular Surface Science ,[object Object],[object Object],[object Object],[object Object]
Nanofilaments: thermionic emission ,[object Object]
Reactivity of metal clusters… ,[object Object]
Molecular surface science… ,[object Object]
PFI-ZEKE Spectroscopy ,[object Object]
ZEKE spectroscopy of Nb clusters Yang  et al .,  J. Electron. Spectrosc. Rel. Phenom..  106  (2000) 153
ZEKE spectroscopy of Nb clusters ,[object Object]
Molecular surface science… ,[object Object],UV of Au n Xe and Au n Xe +
Molecular surface science… ,[object Object],IRMPD of Ag 2 NH 3
Molecular surface science… ,[object Object],FIRMPD of Au 7 Kr
Molecular surface science… ,[object Object],FIRMPD of Au 19  and Au 20
Digital etching of nanostructures I ,[object Object]
Digital etching of nanostructures II ,[object Object],ETCH RATE:  0.9 monolayers per pulse
National Institute for Nanotechnology ,[object Object],Adjuncts NRC Fellows $2M/a $40M $40M $12M/a $20M Interdisciplinary Global Scale $?M/a $20M NINT: Building ($40M) NRC/UofA Shared Nanotech Facility ($40M) ,[object Object],[object Object],[object Object],[object Object],University Aligned Nanotech Research Programs
NINT announcement 2001 ,[object Object]
I believe so much in this model that I’ve picked an area of research I believe is fertile for Canada – quantum information theory and quantum computing – and have invested heavily in it. It’s a fresh, green valley just waiting for us to claim. I have put $133 million so far into the Perimeter Institute for Theoretical Physics and the Institute for Quantum Computing at the University of Waterloo.  Mike Lazaridis CEO,  Research in Motion “
NINT and IQC Thompson-Reuters Web-of-Science, November 2010 SIMS NINT IQC Established 1991 2001 2002 Age 19 9 8 Papers 3130 525 415 Citations 64945 5223 2890 Cites/paper 20.7 10 7 h-index 100 35 25
Growth of Institutes and Centres ,[object Object],INSTITUTE OR CENTRE COUNTRY FIRST PAPER TOTAL PAPERS TOTAL CITATIONS h-index citations per paper Glasgow Univ Nanoelectr Res Centre UK 1988 220 2683 23 12.2 University of Cicinnati Nanoelectonics Lab USA 1990 48 1003 16 20.9 Cornell Univ Natl Nanofab Facility USA 1990 224 4342 34 19.4 Agr Univ Vienna Inst Mol Nanotechnol AUSTRIA 1991 133 3887 36 29.2 Taiwan Natl Nanodevice Lab TAIWAN 1992 441 3827 30 8.7 Paul Scherrer Institute Lab Micro and Nano SWITZERLAND 1993 431 7683 43 17.8 Chalmers Univ Technology SWEDEN 1993 639 7364 38 11.5 University of Birmingham UK 1995 316 3757 32 11.9 Rice University Nano Ctr and Smalley Inst USA 1995 895 64393 116 71.9 Smalley Institute USA 2005 260 3247 29 12.5 University of Cambridge UK 1997 286 4948 34 17.3 Forschungszentrum Karlsruhe GERMANY 1999 1490 29206 73 19.6 All CAS INSTITUTES and CENTRES CHINA 2000 1363 10917 45 8.0 All CNRS INSTITUTES and CENTRES FRANCE 2001 3431 34026 64 9.9 University of Twente HOLLAND 2001 1285 13343 49 10.4 MESA Inst Nanotechnol HOLLAND 2003 1006 9713 43 9.7 NIAIST Nanotechnol Res Inst JAPAN 2001 1222 9662 41 7.9 California Nanosystems Institute USA 2002 867 21165 72 24.4 Purdue University Birck Nanotechnol Centre USA 2003 744 6895 36 9.3 NINT CANADA 2003 539 5381 36 10.0 ALL NANO INSTITUTES LISTED ABOVE 15840 247442 15.6
NANOTECHNOLOGY  POTENTIAL
Institute for Quantum Computing
Institute for Quantum Computing
Three slit experiment ,[object Object]
Nanotechnology and nanoscience ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Single tungsten atom STM tip… ,[object Object]
In-line holographic electron microscopy in presence of magnetic fields ,[object Object]
…  enables atom-resolving holographic microscope ,[object Object]
Molecular electronics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Still not portable devices… ,[object Object]
… but neither was the transistor in the beginning
A new concept for computing ,[object Object],May 19, 2010
A taxonomy for nano-information processing technologies ,[object Object]
Charge qubit quantum computing ,[object Object],“… extremely high tunneling rate, 1014s-1, greatly exceeds expected decoherence rates for a silicon-based system, thereby overcoming a critical obstacle of charge qubit quantum computing.”
[object Object],Low cost crystalline nanosilver 5 – 10 nanometre silver particles grown by new, proprietary, economical technique Crystalline atomic planes  visible under extreme magnification Electron diffraction proves  planes are crystalline metallic silver Silver ion-exchanged sedimentary chabazite annealed at 400  o C
Synthetic platy chabazites ,[object Object],(a) Synthetic chabazite analog   (b) Mineral chabazite
Alberta Nanometals ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],.
PolyBAIT technology platform ,[object Object],Toxin Template Drug
Applications of PolyBAIT technology ,[object Object],[object Object],[object Object],[object Object],[object Object]
Starfish inhibitor for Shiga toxins ,[object Object]
Inhibitors for Shiga toxin Shiga toxin (Stx) Serum amyloid P component (SAP) Ligand: P k -trisaccharide Ligand: 1,3-glycerol pyruvate
Polymeric hetero-bifunctional ligands ,[object Object]
Inter-operative MRI ,[object Object]
Inter-operative MRI and Neuroarm ,[object Object]
Core-shell nano-particles ,[object Object],Fe x O y @SiO 2
Paramagnetic cores with fluorescent shells ,[object Object],Fe x O y @SiO 2 @SiO-Rubpy
[object Object],Gold coated paramagnetic particles
The possibility of single cell surgery ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Chimigen ®  Platform  Technology ,[object Object],[object Object],[object Object],[object Object],[object Object]
Chimigen ®  Platform  Technology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Chimigen ®  Platform  Technology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Malaria Vaccine Antigens ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Rajan George, CTO, Paladin Biosciences
Chimigen ®  Malaria Vaccine ,[object Object],Multi-antigen vaccine Targets parasite at various stages of the infection S-S S-S S S Malaria antigens (CSP/AMA-1/LSA-1 20 repeats /MSP-1 42 ) HBV Core Peptide Linker Portion of C H 1 Hinge Region Xenotypic (Murine)Fc CHO C H 2 IRD 6xHis CH2 C H 3 C H 2 6xHis C H 3 S S S S S S Peptide CHO CHO CHO Malaria antigens (CSP/AMA-1/LSA-1 20 repeats /MSP-1 42 ) HBV Core TBD
Two prophylactic/therapeutic vaccine candidates ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
TECHNOLOGY TO MARKET
Commercialization pathways
Commercialization pathways Research Commercialization Pathway Comment Low cost nanosilver ALBERTA NANOMETALS UofA Spin off Single atom electron source MNE co-development NRC-NINT Automated cellular automata Venture Capital Sought NRC-NINT Silicon charge qubit Inter-operative MRI IMRIS INC (TSE) UofC NRC Spin Off Robotic surgery NEUROARM INC UofC Spin Off PolyBAIT THERACARB UofA Spin Off Chimgen nanoparticles PALADIN BIOSCIENCES UofA Spin Off
I have mentioned that we should be looking at greater change, research of greater global relevance, and I have used my words carefully… I urge each of us to work together to make this possible in its true form where this institute not only files major numbers of patents compared to what it did before,  not only pursues technical excitement, but actually contributes to a new way of life both in India but also elsewhere. Ratan Tata President, IISc Court Indian Institute of Science “
MESA+ must remind industry of the cruel and conveniently overlooked fact that when it focuses on the comfortingly familiar activities of cash management, engineering improvement of existing ideas and commoditization of its products, it loses proprietary advantage , cost advantage, margin, and ultimately the business itself.  Universities and industry must cooperate – to mutual advantage – around nano to keep fresh ideas and fresh minds coming. George M. Whitesides Harvard University MESA+ Scientific Advisory Board “
…  the students as graduates will commercialize everything they learn – whether discovered in Canada or discovered somewhere else. They will form the society of our future based on the education they’ve experienced.  Mike Lazaridis CEO,  Research in Motion “
In the 20-year history of Research In Motion, I have licensed exactly two technologies from university research teams. Over that same period I have hired more than 5,000 students as co-ops, interns, and full time employees. I’ve even hired some of their professors. When I decided to build radios and introduce CAD into our engineering processes, I didn’t go looking for patents. I went looking for great people and found them in our universities.  Mike Lazaridis CEO,  Research in Motion “
NANOTECHNOLOGY PITFALLS
Popular Press ,[object Object]
Early days of nano-agriculture ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Anticipated applications in NA… ,[object Object],[object Object],[object Object],[object Object]
… and Europe ,[object Object],[object Object],[object Object],[object Object]
But… ,[object Object]
Viruses are nanotechnology ,[object Object]
Acknowledgements ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The beauty of nanotechnology
Come to Canada
Nanotechnology:  Progress, Potential and Pitfalls Peter Hackett Executive Professor,  School of Business, University of Alberta  Fellow, National Institute for Nanotechnology [email_address] LINKED IN CONNECTIONS WELCOMED
Many men easily do without truth but none is strong enough to do without illusions. Gustave Le Bon (1841-1931) French social psychologist “
Rating Nations on Nanotechology ,[object Object],Technology Development Strength Nanotechnology Activity
Emergence of China ,[object Object]
Emergence of India ,[object Object]
By 2004 quality is uniformly high ,[object Object],COUNTRY PAPERS PUBLISHED IN 2004 CITATIONS RECEIVED CITATIONS PER PAPER h-index USA 8163 226804 27.8 174 CHINA 4293 76727 17.9 94 JAPAN 3253 60696 18.7 87 GERMANY 2399 50621 21.1 92 FRANCE 1603 34432 21.5 72 S KOREA 1489 25437 17.1 69 INDIA 805 14668 18.2 51

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Nanotechnology Progess And Pitfalls

  • 1. Nanotechnology: Progress, Potential and Pitfalls Peter Hackett Executive Professor, School of Business, University of Alberta Fellow, National Institute for Nanotechnology [email_address]
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  • 17. ZEKE spectroscopy of Nb clusters Yang et al ., J. Electron. Spectrosc. Rel. Phenom.. 106 (2000) 153
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  • 27. I believe so much in this model that I’ve picked an area of research I believe is fertile for Canada – quantum information theory and quantum computing – and have invested heavily in it. It’s a fresh, green valley just waiting for us to claim. I have put $133 million so far into the Perimeter Institute for Theoretical Physics and the Institute for Quantum Computing at the University of Waterloo. Mike Lazaridis CEO, Research in Motion “
  • 28. NINT and IQC Thompson-Reuters Web-of-Science, November 2010 SIMS NINT IQC Established 1991 2001 2002 Age 19 9 8 Papers 3130 525 415 Citations 64945 5223 2890 Cites/paper 20.7 10 7 h-index 100 35 25
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  • 40. … but neither was the transistor in the beginning
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  • 50. Inhibitors for Shiga toxin Shiga toxin (Stx) Serum amyloid P component (SAP) Ligand: P k -trisaccharide Ligand: 1,3-glycerol pyruvate
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  • 66. Commercialization pathways Research Commercialization Pathway Comment Low cost nanosilver ALBERTA NANOMETALS UofA Spin off Single atom electron source MNE co-development NRC-NINT Automated cellular automata Venture Capital Sought NRC-NINT Silicon charge qubit Inter-operative MRI IMRIS INC (TSE) UofC NRC Spin Off Robotic surgery NEUROARM INC UofC Spin Off PolyBAIT THERACARB UofA Spin Off Chimgen nanoparticles PALADIN BIOSCIENCES UofA Spin Off
  • 67. I have mentioned that we should be looking at greater change, research of greater global relevance, and I have used my words carefully… I urge each of us to work together to make this possible in its true form where this institute not only files major numbers of patents compared to what it did before, not only pursues technical excitement, but actually contributes to a new way of life both in India but also elsewhere. Ratan Tata President, IISc Court Indian Institute of Science “
  • 68. MESA+ must remind industry of the cruel and conveniently overlooked fact that when it focuses on the comfortingly familiar activities of cash management, engineering improvement of existing ideas and commoditization of its products, it loses proprietary advantage , cost advantage, margin, and ultimately the business itself. Universities and industry must cooperate – to mutual advantage – around nano to keep fresh ideas and fresh minds coming. George M. Whitesides Harvard University MESA+ Scientific Advisory Board “
  • 69. … the students as graduates will commercialize everything they learn – whether discovered in Canada or discovered somewhere else. They will form the society of our future based on the education they’ve experienced. Mike Lazaridis CEO, Research in Motion “
  • 70. In the 20-year history of Research In Motion, I have licensed exactly two technologies from university research teams. Over that same period I have hired more than 5,000 students as co-ops, interns, and full time employees. I’ve even hired some of their professors. When I decided to build radios and introduce CAD into our engineering processes, I didn’t go looking for patents. I went looking for great people and found them in our universities. Mike Lazaridis CEO, Research in Motion “
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  • 79. The beauty of nanotechnology
  • 81. Nanotechnology: Progress, Potential and Pitfalls Peter Hackett Executive Professor, School of Business, University of Alberta Fellow, National Institute for Nanotechnology [email_address] LINKED IN CONNECTIONS WELCOMED
  • 82. Many men easily do without truth but none is strong enough to do without illusions. Gustave Le Bon (1841-1931) French social psychologist “
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Editor's Notes

  1. E.coli 0157:H7
  2. Add image from I Am Legend
  3. TRANSPORT PROCESSES BIO-SELECTIVE SURFACES BIO-SEPARATION MICROFLUIDICS NANO-BIO PROCESSING NUCLEIC ACID ENGINEERING DRUG DELIVERY MODELLING New tool to pursue historically relevant goals.
  4. TRANSPORT PROCESSES BIO-SELECTIVE SURFACES BIO-SEPARATION MICROFLUIDICS NANO-BIO PROCESSING NUCLEIC ACID ENGINEERING DRUG DELIVERY MODELLING New tool to pursue historically relevant goals.
  5. TRANSPORT PROCESSES BIO-SELECTIVE SURFACES BIO-SEPARATION MICROFLUIDICS NANO-BIO PROCESSING NUCLEIC ACID ENGINEERING DRUG DELIVERY MODELLING New tool to pursue historically relevant goals.