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The Real History of #LAMG #LAMG2018

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History of the Lake Arrowhead Microbial Genomes meeting

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The Real History of #LAMG #LAMG2018

  1. 1. #LAMG2018 @phylogenomics The Real History of LAMG2018 September 16, 2018 Lake Arrowhead Microbial Genomes #LAMG2018 Jonathan A. Eisen University of California, Davis @phylogenomics
  2. 2. #LAMG2018 @phylogenomics Lake Arrowhead and Microbial Genomes September 16, 2018 Lake Arrowhead Microbial Genomes #LAMG2018 Jonathan A. Eisen University of California, Davis @phylogenomics
  3. 3. #LAMG2018 @phylogenomics Origin of the Meeting • Who knows how we came up with the name for the meeting?
  4. 4. #LAMG2018 @phylogenomics Origin of the Meeting • Who knows how we came up with the name for the meeting? • It all relates to the acronym LAMG
  5. 5. #LAMG2018 @phylogenomics Started with a Motorcycle Group
  6. 6. #LAMG2018 @phylogenomics One of their members Luis Gort
  7. 7. #LAMG2018 @phylogenomics Got in Trouble with the Law
  8. 8. #LAMG2018 @phylogenomics Left to Start a Gaming Club
  9. 9. #LAMG2018 @phylogenomics Then Joined A Computer Group
  10. 10. #LAMG2018 @phylogenomics And Got into Algebraic Multigrids
  11. 11. #LAMG2018 @phylogenomics Moved to Los Alamos to Work on Algebraic Grids
  12. 12. #LAMG2018 @phylogenomics Met Founders of Genbank
  13. 13. #LAMG2018 @phylogenomics Discovered a Novel Fold
  14. 14. #LAMG2018 @phylogenomics Abedin & King Found Unusual Pattern for Fold Cadherin-mediated cell adhesion and signaling is essential for metazoan development and yet is absent from all other multicellular organisms. We found cadherin genes at numbers similar to those observed in complex metazoans in one of the closest single-celled relatives of metazoans, the choanoflagellate Monosiga brevicollis. Because the evolution of metazoans from a single-celled ancestor required novel cell adhesion and signaling mechanisms, the discovery of diverse cadherins in choanoflagellates suggests that cadherins may have contributed to metazoan origins.
  15. 15. #LAMG2018 @phylogenomics LAMG Domain Evolution • If LAMG is in Choanoflagellates, where else could it be found? • Decided they needed to start a conference to help spur out this search • They had already registered LAMG domain names • So launched a meeting
  16. 16. #LAMG2018 @phylogenomics LAMG Meeting Try #1 • Leeuwenhoek’s Animacules Many Genes meeting • Nobody came
  17. 17. #LAMG2018 @phylogenomics LAMG Meeting Try #1 • Leeuwenhoek’s Animacules Many Genes meeting • Nobody came • Discovered similarity between Jeffrey Miller & Leewenhoek
  18. 18. #LAMG2018 @phylogenomics LAMG Meeting Try #1 • Leeuwenhoek’s Animacules Many Genes meeting • Nobody came • Discovered similarity between Jeffrey Miller & Leewenhoek • Convinced Jeff to start meeting
  19. 19. #LAMG2018 @phylogenomics Lake Arrowhead Microbial Genomes • v • See http://www.lamg.info/history for the real history
  20. 20. #LAMG2018 @phylogenomics History of the Meeting • And see http://microbe.net/lake-arrowhead- microbial-genomes-history/ for 1998-2016 notes • http://tinyurl.com/LAMG16
  21. 21. #LAMG2018 @phylogenomics Real History of Arrowhead QUOTES, QUOTES, QUOTES
  22. 22. #LAMG2018 @phylogenomics 2002 • Leave it to Jeff Miller to take a shot at the Gordon Conferences in his intro • It looks like someone with a bad cold sneezed against the wall • Wild mistakes - brilliant guesses • He lied about the size of anthrax • If it grows you win, if it doesn’t you have to give me your soul for all eternity • That’s because she has the arrogance of the aristocrats
  23. 23. #LAMG2018 @phylogenomics 2004 • He wanted to keep his finger in the Chlamydia stuff • Engineering other systems that don’t suck • It’s like a tootsie pop • Space time continuum of genes and genomes • The wormhole that allows us to tunnel into today’s world
  24. 24. #LAMG2018 @phylogenomics 2008 • The $1 genome - .... Oh bleep were bleeped
  25. 25. #LAMG2018 @phylogenomics 2014 … • I am spending bioinformatic time up the wazoo • It may be sh*t to you but it's my bread and butter
  26. 26. #LAMG2018 @phylogenomics 2016 • Epigenetics is the ancient aliens of science • Last but not least --- wow --- that did not render well at all • We were relying on them to poop • Here it is again drawn out in an almost unreadable way
  27. 27. #LAMG2018 @phylogenomics 2016 • We introduced this intra-rectally • Architects like the word "speculative" as much as biologists like the word “putative • I don't know why I chose and odd number to then try to divide in half and half • This doesn't actually mean anything it is just cool
  28. 28. #LAMG2018 @phylogenomics 2016 • We have also curated information that we thought was too boring for other people to do • You are usually not sitting in a room by yourself — pauses — but maybe you are • I am going to show you this dense and incomprehensible heat map • It is a question for you but a pet peeve of mine • I didn't mean to say that, I really didn’t
  29. 29. #LAMG2018 @phylogenomics 2016 • I do want to give a shout out to my advisor for letting me spend lots of money • Putting this all together what have we learned? - I like colorful images • I would like to say gonorrheae kills a ton of people (but it doesn’t) • What we want to do is go snorkeling in the microbiome
  30. 30. #LAMG2018 @phylogenomics Other years • Space-time continuum of genes and genomes
  31. 31. #LAMG2018 @phylogenomics Quotes • Space-time continuum of genes and genomes • Microbes not only have a lot of sex, they have a lot of weird sex
  32. 32. #LAMG2018 @phylogenomics Quotes • Space-time continuum of genes and genomes • Microbes not only have a lot of sex, they have a lot of weird sex • Gene sequences are the wormhole that allows one to tunnel into the past
  33. 33. #LAMG2018 @phylogenomics Quotes • Space-time continuum of genes and genomes • Microbes not only have a lot of sex, they have a lot of weird sex • Gene sequences are the wormhole that allows one to tunnel into the past • This is how you do metagenomics on 50 dollars, and that’s Canadian dollars
  34. 34. #LAMG2018 @phylogenomics Quotes • Space-time continuum of genes and genomes • Microbes not only have a lot of sex, they have a lot of weird sex • Gene sequences are the wormhole that allows one to tunnel into the past • This is how you do metagenomics on 50 dollars, and that’s Canadian dollars • The human guts are a real milieu of stuff
  35. 35. #LAMG2018 @phylogenomics Quotes • Space-time continuum of genes and genomes • Microbes not only have a lot of sex, they have a lot of weird sex • Gene sequences are the wormhole that allows one to tunnel into the past • This is how you do metagenomics on 50 dollars, and that’s Canadian dollars • The human guts are a real milieu of stuff • Antibiotics do not kill things, they corrupt them
  36. 36. #LAMG2018 @phylogenomics Quotes • There comes a point in life when you have to bring chemists into the picture
  37. 37. #LAMG2018 @phylogenomics Quotes • There comes a point in life when you have to bring chemists into the picture • The rectal swabs are here in tan color
  38. 38. #LAMG2018 @phylogenomics Quotes • There comes a point in life when you have to bring chemists into the picture • The rectal swabs are here in tan color • If I have time I will tell you about a dream
  39. 39. #LAMG2018 @phylogenomics Quotes • There comes a point in life when you have to bring chemists into the picture • The rectal swabs are here in tan color • If I have time I will tell you about a dream • Another thing you need to know" pause "Actually you don't NEED to know any of this
  40. 40. #LAMG2018 @phylogenomics Quotes • There comes a point in life when you have to bring chemists into the picture • The rectal swabs are here in tan color • If I have time I will tell you about a dream • Another thing you need to know" pause "Actually you don't NEED to know any of this • I have been influenced by Fisher Price throughout my life
  41. 41. #LAMG2018 @phylogenomics Quotes • There comes a point in life when you have to bring chemists into the picture • The rectal swabs are here in tan color • If I have time I will tell you about a dream • Another thing you need to know" pause "Actually you don't NEED to know any of this • I have been influenced by Fisher Price throughout my life • This is going to be ironic coming from someone who studies circumcision
  42. 42. #LAMG2018 @phylogenomics Quotes • And we will bring out the unused cheese from yesterday
  43. 43. #LAMG2018 @phylogenomics Quotes • And we will bring out the unused cheese from yesterday • A paper came out next year
  44. 44. #LAMG2018 @phylogenomics Quotes • And we will bring out the unused cheese from yesterday • A paper came out next year • It takes 1000 nanobiologists to make one microbiologist
  45. 45. #LAMG2018 @phylogenomics Quotes • And we will bring out the unused cheese from yesterday • A paper came out next year • It takes 1000 nanobiologists to make one microbiologist • In an engineering sense, the vagina is a simple plug flow reactor
  46. 46. #LAMG2018 @phylogenomics Quotes • And we will bring out the unused cheese from yesterday • A paper came out next year • It takes 1000 nanobiologists to make one microbiologist • In an engineering sense, the vagina is a simple plug flow reactor • The human mind can conceive of things with no basis in physical reality
  47. 47. #LAMG2018 @phylogenomics Quotes • And we will bring out the unused cheese from yesterday • A paper came out next year • It takes 1000 nanobiologists to make one microbiologist • In an engineering sense, the vagina is a simple plug flow reactor • The human mind can conceive of things with no basis in physical reality • Thoughts can go faster than the speed of light
  48. 48. #LAMG2018 @phylogenomics Quotes • We are the environment. We live the phenotype. •
  49. 49. #LAMG2018 @phylogenomics Quotes • We are the environment. We live the phenotype. • We have been using this word for many years without actually realizing it was correct
  50. 50. #LAMG2018 @phylogenomics Quotes • We are the environment. We live the phenotype. • We have been using this word for many years without actually realizing it was correct • A little bit about time, but I am going to spend a lot less time on time than on space
  51. 51. #LAMG2018 @phylogenomics Quotes • We are the environment. We live the phenotype. • We have been using this word for many years without actually realizing it was correct • A little bit about time, but I am going to spend a lot less time on time than on space • I am going to wrap up as I hear the crickets chirping
  52. 52. #LAMG2018 @phylogenomics 2018

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