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Antifungal agent
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Anti leprotic agent

  1. 1. Mr. Pankaj Kusum Ramdas Khuspe M. Pharmacy ANTILEPROTIC DRUGS
  2. 2. SYLLABUS Dapsone* Clofazimine Thiambutosine Solapsone ©Mr. Pankaj Kusum Ramdas Khuspe
  3. 3. QUESTION BANK 1. Give structures and IUPAC (chemical) name of Dapsone. 2. Give properties, stability, storage and uses of A. Thiambutosine B. Clofazimine ©Mr. Pankaj Kusum Ramdas Khuspe
  4. 4. Definition The agents Which are Used In treatment Of leprosy. E.g.: Dapsone ©Mr. Pankaj Kusum Ramdas Khuspe
  5. 5. LEPROSY ©Mr. Pankaj Kusum Ramdas Khuspe  It also known as Hansen's disease  It is a chronic infectious disease caused by Mycobacterium leprae.  The disease mainly affects, a. the skin, b. the peripheral nerves, c. mucosal surfaces of the upper respiratory tract and d. the eyes.
  6. 6. ANTILEPROTIC DRUGS The agents which are used in treatment of leprosy. E.g.: Dapsone Classification:  Sulphones : E.g.: Dapsone  Thiosemicarbazone derivatives : E.g.: Thiambutosine  Phenazine (diaminophenazine) derivatives : E.g.: Clofazimine©Mr. Pankaj Kusum Ramdas Khuspe
  7. 7. DAPSONE ©Mr. Pankaj Kusum Ramdas Khuspe 4,4’-Diamino diphenyl sulphone Or Bis (4-amino phenyl) sulphone AMINO PHENYL SULPHON E
  8. 8. DAPSONE ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white or creamy white crystalline powder. 2. It is odorless 3. It has slightly bitter taste 4. It is very slightly soluble in water. 5. It is soluble in acetone and in dilute mineral acids. Storage: It should be stored in well closed light resistant container at cool place away from direct sunlight.
  9. 9. DAPSONE ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used in treatment of leprosy. 2. It is used in treatment of malaria. 3. It is used in treatment of dermatitis heroetiformis and relapsing polychondritis. 4. It also used in treatment of pneumonia by combination of trimethoprim. Official preparation: Dapsone I.P, B.P, U.S.P Dapsone tablet I.P Brand name: Dubronax
  10. 10. CLOFAZIMINE ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is dark red or orange red crystalline powder. 2. It is characteristic odor 3. It is insoluble in water. 4. It is soluble in organic solvants. Storage: It should be stored in well closed container at cool place away from direct sunlight.
  11. 11. CLOFAZIMINE ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used in treatment of leprosy. 2. It is used in treatment of lepromatous leprosy Official preparation: Clofazimine I.P, B.P Clofazimine tablet I.P Brand name: Clofozine, Lamprene
  12. 12. THIAMBUTOSINE ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white or creamy white crystalline powder. 2. It is odorless 3. It has slightly bitter taste 4. It is very soluble in water. 5. It is soluble in acetone. Storage: It should be stored in well closed light resistant container at cool place away from direct sunlight.
  13. 13. THIAMBUTOSINE ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used in treatment of leprosy. 2. It is used in treatment of tuberculoid leprosy. 3. It is used in treatment of severe neuritis. Official preparation: Thiambutosine I.P, U.S.P Thiambutosine tablet I.P Brand name: Ciba 1906
  14. 14. SOLAPSONE ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white or creamy white crystalline powder. 2. It is odorless 3. It is very soluble in water. 4. It is soluble in acetone. Storage: It should be stored in well closed light resistant container at cool place away from direct sunlight.
  15. 15. SOLAPSONE ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used in treatment of leprosy. Official preparation: Solapsone I.P Brand name: Dubronax, Cimedone; Sulphetrone; Solasulfone: Solasulfonum

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