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Anti tubercular agent

  1. 1. Mr. Pankaj Kusum Ramdas Khuspe M. Pharmacy ANTI TUBERCULAR DRUGS
  2. 2. SYLLABUS ©Mr. Pankaj Kusum Ramdas Khuspe ISONIAZID*, PAS*, ETHAMBUTOL* PYRAZINAMIDE * STREPTOMYCIN , RIFAMPICIN, THIACETAZONE, ETHIONAMIDE, CYCLOSERINE,
  3. 3. QUESTION BANK 1. Give structures and IUPAC (chemical) name, properties and uses of Isoniazid*, 2. Give structures and IUPAC (chemical) name, official preparation, and brand name of PAS*, 3. Give structures and IUPAC (chemical) name properties and official preparation of Ethambutol* 4. Give structures and IUPAC (chemical) name of Pyrazinamide 5. Give structure, properties, stability, storage and uses of a) Streptomycin, b) Rifampicin ©Mr. Pankaj Kusum Ramdas Khuspe
  4. 4. TUBERCULOSIS ©Mr. Pankaj Kusum Ramdas Khuspe  It is a contagious infection.  A type of bacteria called Mycobacterium tuberculosis causes it.  It usually attacks your lungs.  It can also spread to other parts of your body, like your brain and spine.  Tuberculosis is caused by bacteria that spread through the air (Airborne disease)  It is communicable disease.
  5. 5. Definition The agents Which are Used In treatment Of tuberculosis. E.g.: Isoniazid, etc ©Mr. Pankaj Kusum Ramdas Khuspe
  6. 6. Definition The agents which are used in treatment tuberculosis. E.g.: Isoniazid, etc Classification: 1. First line drugs or agents : E.g.: Isoniazid 2. Second line drugs or agents : E.g.: Cycloserine©Mr. Pankaj Kusum Ramdas Khuspe
  7. 7. ISONIAZID ©Mr. Pankaj Kusum Ramdas Khuspe Pyridine-4-carbohydrazide Or Isonicotinic Acid Hydrazide (INH) Carbohydrazi de Pyridin e
  8. 8. ©Mr. Pankaj Kusum Ramdas Khuspe Synonyms: INH, Isonocitinyl hydrazide, Isonicitino hydrazide, Isonicotinic acid hydrazide. Properties: 1. It is colorless or white crystalline powder 2. It is odorless, 3. It is having sweet taste. 4. It is soluble in water. 5. It is sparingly soluble in alcohol. 6. It gets affected by exposure to air and light. Storage: It should be stored in well closed airtight light resistant container at cool place away from direct sunlight. ISONIAZID
  9. 9. ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used in treatment of tuberculosis. 2. It is used in treatment of meningitis 3. It is used in treatment of urinary tract infections. Official preparation: #Isoniazid I.P, B.P, U.S.P #Isoniazid tablets I.P, B.P, U.S.P # Isoniazid elixir I.P, B.P, # Isoniazid injection I.P, B.P, Brand name:  Cadizide, Isonix, Rifamzid, Isocadipas. ISONIAZID
  10. 10. PAS ©Mr. Pankaj Kusum Ramdas Khuspe BENZOIC ACID HYDROX Y AMINO 4-amino, 2-hydroxy benzoic acid
  11. 11. ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white power 2. It has slight odor. 3. It having slightly acid taste. 4. It is sparingly in water. 5. It is more soluble in alcohol. 6. It is darkens on exposure to light and air. Storage: It should be stored in well closed in air tight light resistant container at cool place away from direct sunlight. PAS (Para amino salicylic acid OR 4-amino salicylic acid )
  12. 12. ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used in treatment of tuberculosis. 2. It is used in treatment of resistant tuberculosis by combination with other anti TB drugs. Official preparation: #Amino salicylic acid I.P, B.P, U.S.P #Amino salicylic sodium tablets I.P #Amino salicylic acid tablets I.P, B.P #Amino salicylic Potassium tablets I.P #Amino salicylic calcium tablets I.P Brand name:  Idipas, Isopas, Benzapas PAS
  13. 13. ETHAMBUTOL ©Mr. Pankaj Kusum Ramdas Khuspe Bis-(1-hydroxy methyl propyl) ethylene diamine OR N,N’-Ethylene-Bis (2 -amino-butan-1-ol) (1-hydroxy methyl propyl) Ethylene Diamine
  14. 14. ©Mr. Pankaj Kusum Ramdas Khuspe Properties:  It is white crystalline powder  It is odorless  It is freely soluble in water.  It is Chemically it is an aliphatic diamine.  The dextro isomer is more potent levo isomer Storage: It should be stored in well closed container at cool place away from direct sunlight. ETHAMBUTOL
  15. 15. ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used in treatment of tuberculosis. 2. It is used in treatment of pulmonary Culosis. 3. It is used in treatment of resistant tuberculosis by combination with other anti TB drugs. Official preparation: # Ethambutol hydrochloride I.P., B.P. # Ethambutol powder I.P., B.P. # Ethambutol hydrochloride tablet I.P., B.P. Brand name:  Myambutol, Albutol, Ly-butol ETHAMBUTOL
  16. 16. PYRAZINAMIDE ©Mr. Pankaj Kusum Ramdas Khuspe Pyrazine -2- Carboxamide CARBOXAMID E PYRAZINE
  17. 17. ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white crystalline powder 2. It is odorless, 3. It is having slightly bitter taste. 4. It is sparingly soluble in water. 5. It is soluble in ether and chloroform. Storage: It should be stored in well closed container at cool place away from direct sunlight. PYRAZINAMIDE
  18. 18. ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used in treatment of tuberculosis. 2. It is used in treatment of resistant tuberculosis by combination with other anti TB drugs. Official preparation:  Pyrazinamide I. P, B. P, U.S.P  Pyrazinamide Tablet I. P, B. P, Brand name:  Zinamide, Pyride, Pyrina-500 PYRAZINAMIDE
  19. 19. STREPTOMYCIN ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white powder. 2. It is odorless. 3. It has slightly bitter taste. 4. It is very soluble in water. 5. It is sparingly soluble in alcohol. 6. It is affected by moisture and heat. Storage: It should be stored in well closed airtight light resistant container at cool place away from direct sunlight.
  20. 20. STREPTOMYCIN ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used in treatment tuberculosis. 2. It is used in treatment of large intestine infections. 3. It is used in treatment of tubercular meningitis. Official preparation: Streptomycin I.P, B.P, U.S.P Streptomycin tablet I.P, B.P Streptomycin Injection I.P, B.P Brand name:  Chlorostrep, Enterostrep, Lykastrep, Streptomex
  21. 21. RIFAMPICIN ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is brick red or reddish brown crystalline powder. 2. It is odorless. 3. It is slightly soluble in water and alcohol. 4. It is soluble in chloroform 5. It is unstable in moisture, air and light. Storage: It should be stored in well closed air tight light resistant container at cool place away from direct sunlight.
  22. 22. RIFAMPICIN ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used in treatment of tuberculosis. 2. It is used in treatment of biliary infections. 3. It is used in treatment of meningitis. Official preparation: Rifampicin I.P, B.P, U.S.P Rifampicin capsule I.P, B.P Brand name:  Rimpin, Rimpacin
  23. 23. THIACETAZONE or THIOACETAZONE ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is pale yellow crystalline powder. 2. It is odorless. 3. It is very slightly soluble in water. 4. It is soluble in propylene gycol. 5. It is affected by light. Storage: It should be stored in well closed light resistant container at cool place away from direct sunlight.
  24. 24. ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used in treatment of tuberculosis. 2. It is used in treatment of leprosy. Official preparation: Thiacetazone I.P, B.P Thiacetazone tablets I.P Brand name:  Thiopramizone, Thioce Vit, Decetazone. THIACETAZONE or THIOACETAZONE
  25. 25. ETHIONAMIDE ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is bright yellow crystalline powder. 2. It has slight characteristic odor. 3. It has unpleasant taste. 4. It is practically insoluble in water. 5. It is affected by light Storage: It should be stored in well closed light resistant container at cool place away from direct sunlight.
  26. 26. ETHIONAMIDE ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used in treatment of tuberculosis. 2. It is used in treatment of resistant tuberculosis by combination with other anti TB drugs. Official preparation: Ethionamide I.P, B.P Ethionamide tablet I.P Brand name:  Ethinex, Trescalyl
  27. 27. CYCLOSERINE or SEROMYCIN ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white or pale yellow crystalline powder. 2. It is odorless. 3. It has slightly bitter taste. 4. It is hygroscopic. 5. It is soluble in water. Storage: It should be stored in well closed in air tight container at cool place away from direct sunlight not exceeding 25oC.
  28. 28. ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used in treatment tuberculosis. 2. It is used in treatment of pulmonary tuberculosis. 3. It is also used in treatment of urinary tract infections. Official preparation: Cycloserine I.P, B.P Cycloserine tablet I.P Cycloserine capsule I.P Brand name:  Cycosin, Themiserine. CYCLOSERINE or SEROMYCIN
  29. 29. Any question??? Thank you… ©Mr. Pankaj Kusum Ramdas Khuspe

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