Se ha denunciado esta presentación.
Se está descargando tu SlideShare. ×
Anuncio
Anuncio
Anuncio
Anuncio
Anuncio
Anuncio
Anuncio
Anuncio
Anuncio
Anuncio
Anuncio
Anuncio
Próximo SlideShare
SULPHONAMIDES
SULPHONAMIDES
Cargando en…3
×

Eche un vistazo a continuación

1 de 29 Anuncio

Antimalarial agent

Descargar para leer sin conexión

PHARMACEUTICAL CHEMISTY II, Antimalarial Drugs-Chloroquine*, Amodiaquine, Primaquine, Proguanil, Pyrimethamine*, Quinine, Trimethoprim.
Pharmaceutical official formulations of drugs and their popular brand names

PHARMACEUTICAL CHEMISTY II, Antimalarial Drugs-Chloroquine*, Amodiaquine, Primaquine, Proguanil, Pyrimethamine*, Quinine, Trimethoprim.
Pharmaceutical official formulations of drugs and their popular brand names

Anuncio
Anuncio

Más Contenido Relacionado

Presentaciones para usted (20)

Similares a Antimalarial agent (20)

Anuncio

Más de Pankaj Kishori Kusum Ramdas Khuspe (14)

Más reciente (20)

Anuncio

Antimalarial agent

  1. 1. Mr. Pankaj Kusum Ramdas Khuspe M. Pharmacy ANTI-MALARIAL DRUGS
  2. 2. LEARNING OBJECTIVES ©Mr. Pankaj Kusum Ramdas Khuspe Upon Completion of the chapter Student will; a. Understand the definition and classification of Anti-malarial agent. b. Recall and Rewrite the structure of Chloroquine and Pyrimethamine c. Able to rewrite the properties and used of Anti- malarial agent. d. Examine various official preparation in market. e. Select the product as per brand names.
  3. 3. SYLLABUS 1. Chloroquine* 2. Pyrimethamine* 3. Amodiaquine 4. Primaquine 5. Proguanil 6. Quinine 7. Trimethoprim. ©Mr. Pankaj Kusum Ramdas Khuspe
  4. 4. QUESTION BANK 1. Define and classify anti malarial agents.(4M) 2. Classify Antimalarial agents. Also give the structure of Chloroquine with chemical name. (4M) 3. Give structures and IUPAC (chemical) name, properties and uses of Chloroquine or Pyrimethamine. (3M) 4. Give structure, properties, stability, storage and uses of (3M) a) Amodiaquine b) Primaquine c) Proguanil ©Mr. Pankaj Kusum Ramdas Khuspe
  5. 5. MALARIA ©Mr. Pankaj Kusum Ramdas Khuspe  Malaria is an infectious disease caused by protozoa; plasmodium.  It’s typically transmitted through the bite of an infected Anopheles mosquito.  Following species of plasmodium causing malaria in humans 1. P. falciparum 2. P. vivax, 3. P. malariae, 4. P. ovale. Common symptoms of malaria include:  Shaking chills that can range from moderate to severe, high fever, Headache, nausea, vomiting, abdominal
  6. 6. Definition drugs are intended to treat and prevent malaria by killing the parasite in the liver or the bloodstream. i.e. Anti-malarial drugs are intended to treat and prevent malaria by killing the parasite in the liver or the bloodstream. E.g.: Chloroquine, Pyrimethamine etc ©Mr. Pankaj Kusum Ramdas Khuspe
  7. 7. Definition chemical agent, that can be used  to treat or to prevent malaria. i.e. Anti malarial are the chemical agent, that can be used to treat or to prevent malaria. E.g.: Chloroquine, Pyrimethamine etc Or The drugs which are used in the treatment of malaria caused due to Plasmodium Species as Anti- malarial drugs. E.g.: Chloroquine, Pyrimethamine etc ©Mr. Pankaj Kusum Ramdas Khuspe
  8. 8. ©Mr. Pankaj Kusum Ramdas Khuspe • Chloroquine, Hydroxychloroquine4 aminoquinolines • Primaquine8 aminoquinolines • Quinine, QuinidineCinchona alkaloids • MefloquineQuinoline methanol • Proguanil, ChlorproguanilBiguanides • PyrimethamineDiaminopyrimidines • Sulfadoxine, dapsoneSulfonamides • Tetracycline, DoxycyclineTetracyclines • AtovaquoneNaphthoquinone • Artesunate, Artemether,Sesquiterpene lactones ©Mr. Pankaj Kusum Ramdas Khuspe CLASSIFICATION
  9. 9. ©Mr. Pankaj Kusum Ramdas Khuspe CLASSIFICATION CLASS EXAMPLES 4 amino-quinolines Chloroquine, Hydroxychloroquine, 8 aminoquinoline Primaquine Cinchona alkaloids Quinine, Quinidine Quinoline methanol Mefloquine Biguanides Proguanil, Chlorproguanil Diaminopyrimidines Pyrimethamine Sulfonamides Sulfadoxine, dapsone Tetracyclines Tetracycline, Doxycycline Naphthoquinone Atovaquone Sesquiterpene lactones Artesunate, Artemether,
  10. 10. CHLOROQUINE ©Mr. Pankaj Kusum Ramdas Khuspe 7-Chloro-4-[4’-(diethylamino)-1-methyl butyl] amino quinoline
  11. 11. ©Mr. Pankaj Kusum Ramdas Khuspe 7-Chloro-4-[4’-(diethylamino)-1-methyl butyl] amino quinoline
  12. 12. CHLOROQUINE ©Mr. Pankaj Kusum Ramdas Khuspe amino Quinolin e chloro Diethyl amino 1-methyl butyl
  13. 13. CHLOROQUINE ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white crystalline powder. 2. It is odorless. 3. It has a bitter taste. 4. It is freely soluble in water. 5. It is slightly soluble in chloroform. 6. It affected by light. Storage: It should be stored in well closed light resistant air tight container at cool place away from direct sunlight.
  14. 14. CHLOROQUINE ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as anti malarial agent. 2. It is used to: 1) To suppress and cure malaria. 2) To treat amoebic hepatitis. 3) To treat giardiasis. 4) To treat chronic discoid and systemic lupus erythematous. 5) To treat rhematoid arthritis. Official preparation: # Chlroquine I.P, B.P, U.S.P # Chlroquine Phosphate Injection I.P, B.P # Chlroquine Phosphate Tablets I.P, B.P # Chlroquine Syrup I.P, B.P # Chroquine Sulphate Injection I.P, B.P # Chroquine Sulphate tablet I.P, B.P Brand Names: Cadiquin, Cloquin, Emquin, Lariago, Aralen, Avioclor, Quinross, Resochin, Nivaquine
  15. 15. PYRIMETHAMINE ©Mr. Pankaj Kusum Ramdas Khuspe 5-(4-Chlorophenyl)-6-ethyl-2,4- pyrimidinediamine Ethyl 2,4- pyrimidinediamine 4-Chlorophenyl
  16. 16. PYRIMETHAMINE ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white crystalline powder. 2. It is odourless. 3. It is tasteless. 4. It is practically insoluble in water. 5. It is soluble in warm dilute mineral acids. 6. It is affected by light. Storage conditions: It should be stored in well closed light resistant container at cool place away from direct sunlight.
  17. 17. PYRIMETHAMINE ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as anti malarial agent. 2. It is used a. Prophylaxis of malaria. b. To treat toxoplasmosis. c. With dapsone used for enhancement of anti-malarial activity. Official preparation: # Pyrimethamine I.P, B.P, U.S.P # Pyrimethamine tablets I.P, B.P, U.S.P Brand name: Pyralfin, Daraprim, Onli-2
  18. 18. AMODIAQUINE ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is yellow crystalline powder. 2. It is odorless 3. It has bitter taste. 4. It is soluble in water. 5. It is slightly soluble in ethanol. 6. It is insoluble in chloroform and ether. Storage: It should be stored in well closed container at cool place away from direct sunlight.
  19. 19. AMODIAQUINE ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as anti malarial agent. 2. It is used to; a. To suppress and cure malaria. b. To treat amoebic hepatitis. c. To treat giardiasis. d. To treat rheumatoid arthritis. Official preparation: #Amodiaquine I.P, B.P, U.S.P #Amodiaquine hydrochloride I.P, B.P, U.S.P #Amodiaquine tablets I.P, B.P, Brand name:  Camoquine, Flavoquin
  20. 20. PRIMAQUINE ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is orange red crystalline powder. 2. It is odorless 3. It has bitter taste. 4. It is soluble in water. 5. It is practically insoluble in ethanol. 6. It is insoluble in chloroform and ether Storage: It should be stored in well closed container at cool place away from direct sunlight.
  21. 21. PRIMAQUINE ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as anti malarial agent. 2. It is mainly used for treatment and cure of plasmodium vivax infection by conjugation with chloroquin. Official preparation: #Primaquine I.P, B.P, U.S.P #Primaquine Phospahte B.P, U.S.P #Primaquine tablets I.P, B.P, U.S.P Brand name:  Aralon. Primoquine.
  22. 22. PROGUANIL (CHLOROGUINIDE/PALUDRINE) ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white crystalline powder. 2. It is odorless 3. It has bitter taste. 4. It is slightly soluble in water. 5. It is soluble in ethanol. 6. It is practically insoluble in chloroform and ether. 7. It is affected by light. Storage: It should be stored in well closed light resistant container at cool place away from direct sunlight.
  23. 23. PROGUANIL ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as anti malarial agent. 2. It is used a. For short term and long term prophylaxis of falcipuram malaria and associated malaria. b. For long term prophylaxis of vivax malaria. Official preparation: #Proguanil I.P, B.P #Chloroguanide U.S.P # Proguanil hydrochloride I.P, B.P # Proguanil tablets I.P, B.P Brand name:  Paludrine,
  24. 24. QUININE ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is alkaloid obtained from cinchona barks 2. It is white crystalline powder. 3. It is odorless 4. It has very bitter taste. 5. It is very slightly soluble in water. 6. It is soluble in ethanol, dilute ammonia solution. 7. It is slightly soluble in chloroform. 8. It is affected by light. Storage: It should be stored in well closed light resistant container at cool place away from direct sunlight.
  25. 25. QUININE ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as anti malarial agent. 2. It is used; a. To treat severe and complicated malaria by plasmodium falciparum. b. To treat cerebral malaria. c. To relieve nocturnal (night) leg cramp. d. To relieve muscle cramps. Brand name:  Malaria mixture, Flue-foe, Vigotab.
  26. 26. QUININE ©Mr. Pankaj Kusum Ramdas Khuspe Official preparation: #Quinine I.P, B.P, U.S.P #Quinine sulphate I.P, B.P, U.S.P #Quinine sulphate tablets I.P, B.P, U.S.P #Quinine bisulphate I.P, B.P, U.S.P #Quinine bisulphate tablets I.P, B.P, U.S.P #Quinine hydrochloride I.P, B.P, U.S.P #Quinine hydrochloride tablets I.P, B.P, U.S.P #Quinine dihydrochloride I.P, B.P, U.S.P #Quinine dihydrochloride injection I.P, B.P, U.S.P
  27. 27. TRIMETHOPRIM ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white crystalline powder. 2. It is odorless 3. It has bitter taste. 4. It is very slightly soluble in water. 5. It is slightly soluble in ethanol. Storage: It should be stored in well closed container at cool place away from direct sunlight.
  28. 28. TRIMETHOPRIM ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as anti malarial agent. 2. It is used as antimicrobial agent by combination with sulfa drugs. Official preparation: #Trimethoprim I.P, B.P #Trimethoprim & sulphadiazine I.P, B.P Brand name:  Bactrin, Septran
  29. 29. ©Mr. Pankaj Kusum Ramdas Khuspe Thank you…

×