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Antimalarial agent
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Antimoebic drugs

  1. 1. Mr. Pankaj Kusum Ramdas Khuspe M. Pharmacy ANTI-AMOEBIC DRUGS
  2. 2. SYLLABUS ©Mr. Pankaj Kusum Ramdas Khuspe METRONIDAZOLE* EMETINE DILOXANIDE FUROATE, PAROMOMYCIN HALOGENATED HYDROXYQUINOLINES DI-IODOHYDROXYQUIN (IODOQUINOL) IODOHYDROXYQUIN (CLIOQUINOL)
  3. 3. QUESTION BANK 1. Give structures and IUPAC (chemical) name, properties, official preparation and uses of Metronidazole*, 2. Give structure, properties, stability, storage and uses of a) Emetine, b) Paramomycin c) Halogenated Hydroxyquinolines ©Mr. Pankaj Kusum Ramdas Khuspe
  4. 4. AMEBIASIS ©Mr. Pankaj Kusum Ramdas Khuspe  Amebiasis also called amebic dysentery.  It is an infection of intestinal tract caused by Entamoeba histolytica.  The disease can be acute or chronic.  It cause due to poor hygienic conditions and transferred by the faecal-oral route  The patients showing varying degrees of illness,  from no symptoms to  mild diarrhea to fulminating dysentery  Dysentery in which the symptoms are intensely acute, leading to prostration(extremely weak), collapse, and often death.
  5. 5. Definition The agents Which are Used In treatment Of Amebiasis Or Amebic dysentery. E.g.: Metronidazole, Diloxanide Furoate etc “The agents which are used in treatment of amebiasis or amebic dysentery.” E.g.: Metronidazole, Diloxanide Furoate etc©Mr. Pankaj Kusum Ramdas Khuspe
  6. 6. Classification ©Mr. Pankaj Kusum Ramdas Khuspe
  7. 7. METRONIDAZOLE ©Mr. Pankaj Kusum Ramdas Khuspe 1-(2hydroxy ethyl), 2-methyl, 5-nitro Imidazole Or 2-(2-methyl, 5-nitro imidazol-1-yl) ethanol 2-HYDROXY ETHYL IMIDAZOLE METHYL NITRO
  8. 8. ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white or creamy white powder. 2. It is having slight odor. 3. It is having bitter saline taste. 4. It is slightly soluble in water. 5. It is soluble in alcohol. 6. It is affected by light. Storage: It should be stored in well closed light resistant container at cool place away from direct sunlight. METRONIDAZOLE
  9. 9. ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as anti amebic agent. 2. It is also used as anti-protozoal agent. 3. It is used in treatment of septicemia, pneumonia and post operative wound infections. 4. It is used in treatment of Vincent’s disease. 5. It is used in treatment of balantidiasis. Official preparation: #Metronidazole I.P, B.P, U.S.P # Metronidazole tablets I.P, B.P, U.S.P # Metronidazole suppositories I.P, # Metronidazole injection I.P, B.P, Brand name:  Flagyl, Metroquin, Metroquinol. METRONIDAZOLE
  10. 10. ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white crystalline powder 2. It is odorless. 3. It is tasteless. 4. It is very slightly soluble in water. 5. It is soluble in chloroform. 6. It is affected light. Storage: It should be stored in well closed light resistant container at cool place away from direct sunlight. DILOXANIDE FUROATE
  11. 11. ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as anti amebic agent. 2. It is used in treatment of hepatic abscesses by combination with chloroquine or metronidazole. Official preparation:  Diloxanide Furoate I.P, B.P  Diloxanide Furoate Tablet I.P Brand name:  Entamizole, Flagyl-DF, Diloxyl. DILOXANIDE FUROATE
  12. 12. EMETINE ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white or slightly yellow crystalline powder. powder. 2. It is odorless. 3. It has bitter taste. 4. It is soluble in water. 5. It is soluble in alcohol. 6. It is affected by light. Storage: It should be stored in well closed airtight light resistant container at cool place away from direct sunlight.
  13. 13. EMETINE ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as anti amebic agent. 2. It is used in treatment of intestine amoebiasis and hepatic amoebiasis. Official preparation: Emetine I.P, B.P, U.S.P Emetine Injection I.P Brand name:  Stembin,Hemometina
  14. 14. PARAMOMYCIN ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is creamy white or light yellow crystalline powder. 2. It is odorless. 3. It is very soluble in water. 4. It is insoluble in alcohol and chloroform 5. It is hygroscopic. 6. It is unstable in moisture, air and light. Storage: It should be stored in well closed air tight container at cool place away from direct sunlight.
  15. 15. PARAMOMYCIN ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as anti amebic agent. 2. It is used in treatment of intestinal amoebiasis. 3. It is used in treatment of leishmaniasis(Kala Azar). 4. It is used in treatment of balantidiasis. 5. It is also used as anthalmentic activity. Official preparation: Paramomycin I.P, B.P, U.S.P Paramomycin sulphate tablet I.P, B.P Paramomycin sulphate syrup I.P, B.P Brand name:  Paramicina, Hamagel
  16. 16. HALOGENATED HYDROXYQUINOLINES DI-IODOHYDROXYQUIN (IODOQUINOL) ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is pale yellowish to yellowish brown crystalline powder. 2. It is odorless. 3. It is odorless. 4. It is very slightly soluble in water and in alocohol. 5. It is affected by light. Storage: It should be stored in well closed light resistant container at cool place away from direct sunlight.
  17. 17. ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as anti amebic agent. 2. It is used in treatment of intestinal amoebiasis. 3. It is used in treatment of acute dermatitis. Official preparation: Iodoquinol I.P, B.P Iodoquinol tablet I.P, B.P Di-Iodohydroxyquinolone pesseries I.P Brand name:  Diodoquin, Metroquin, Amibiotic. HALOGENATED HYDROXYQUINOLINES DI-IODOHYDROXYQUIN (IODOQUINOL)
  18. 18. HALOGENATED HYDROXYQUINOLINES IODOHYDROXYQUIN (CLIOQUINOL) ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is yellowish to yellowish brown crystalline powder. 2. It is faint characteristic odor. 3. It is odorless. 4. It is very slightly soluble in water and in alcohol. 5. It is soluble in pyridine. 6. It is affected by light. Storage: It should be stored in well closed light resistant container at cool place away from direct sunlight.
  19. 19. ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as anti amebic agent. 2. It is used in treatment of bacilliary dysentery. 3. It is used in treatment of dermatitis. 4. It is used in treatment of fungal infection. Official preparation: #Clioquinol I.P, B.P #Clioquinol cream I.P, B.P #Clioquinol ointmentI.P, B.P Brand name:  Enteroquinol, Enterovioform, Mexaform, Metroquine. HALOGENATED HYDROXYQUINOLINES IODOHYDROXYQUIN (CLIOQUINOL)
  20. 20. Any question??? Thank you… ©Mr. Pankaj Kusum Ramdas Khuspe

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