Se ha denunciado esta presentación.
Se está descargando tu SlideShare. ×
Anuncio
Anuncio
Anuncio
Anuncio
Anuncio
Anuncio
Anuncio
Anuncio
Anuncio
Anuncio
Anuncio
Anuncio
Próximo SlideShare
Anti tubercular agent
Anti tubercular agent
Cargando en…3
×

Eche un vistazo a continuación

1 de 20 Anuncio

Más Contenido Relacionado

Presentaciones para usted (20)

Anuncio

Más de Pankaj Kishori Kusum Ramdas Khuspe (14)

Más reciente (20)

Anuncio

Local anesthetics

  1. 1. Mr. Pankaj Kusum Ramdas Khuspe LOCAL ANAESTHETICS
  2. 2. SYLLABUS Lignocaine* Procaine* Benzocaine
  3. 3. QUESTIONS 1. Define local anaesthetics? Write structure and chemical name of procaine hydrochloride. 2. Classify local anaesthetics with examples. 3. Write the name of the drug with following chemical name and draw its structure a) N- diethyl amino acetyl – 2,6- Xylidine 4. What are ‘Local Anaesthetics’? Write structure, give chemical name of local Anaesthetic drug having following chemical feature. a. Ester b. Amide 5. Differentiate between general and local anesthetics 6. Write the difference between general anaesthetics and local anaesthetics. Give the structure and chemical name of procaine. 7. Draw structure, and Give properties, storage condition &
  4. 4. DEFINITION drugs which  produce insensitivity in a limited area around the site of application or injection of the drug by preventing generation and conduction of impulses “Local anesthetics are drugs which produce insensitivity in a limited area around the site of application or injection of the drug by preventing generation and conduction of impulses.” E.g.: Lidocaine, Procaine etc
  5. 5. DEFINITION  drugs which  produce insensitivity in a limited area  around the site of application or injection of the drug  by preventing generation and  conduction of impulses  along nerve fibers and nerve ending and  the effects are reversible. “Local anesthetics are drugs which produce insensitivity in a limited area around the site of application or injection of the drug by preventing generation and conduction of impulses along nerve fibres and nerve ending and the effects are reversible.”
  6. 6. 1. Esters Esters of benzoic acid- Cocaine Esters of p-amino benzoic acid- Benzocaine, Procaine 2. Amides Aniline amides- Xylocaine (Lignicaine/Lidocaine) Non-anilide amides- Cinchocaine 3. Miscellaneous Compounds Phenol, Eugenol CLASSIFICATION
  7. 7. 1. Natural Products: Cocaine,Tropocaine. 2. Synthetic Compounds : a) Benzoic acid ester derivatives- Hexylcaine, Isobucaine b) Para-amino benzoic acid ester derivatives- Benzocaine, Procaine, Tetracaine hydrochloride c) Amides- Lignocaine, Prilocaine, Bupivacaine, CLASSIFICATION
  8. 8. LIGNOCAINE (LIDOCAINE/ XYLOCAINE) ©Mr. Pankaj Kusum Ramdas Khuspe N-diethyl amino acetyl-2,6-xylidine OR 2-(diethylamino)-N-(2,6-dimethylphenyl) acetamide
  9. 9. LIGNOCAINE ©Mr. Pankaj Kusum Ramdas Khuspe acetyl 2,6- xylidine N-diethyl amino
  10. 10. LIGNOCAINE ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white crystalline powder 2. It is odorless. 3. It has slightly bitter taste. 4. It is very soluble in water. 5. It is freely soluble in alcohol. 6. It is soluble in chloroform. Storage: It should be stored in well closed container at a cool place away from direct sunlight.
  11. 11. LIGNOCAINE ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as local anaesthetic. 2. It is used to produce analgesia in dentistry. 3. In the forms of injection for systemic anaesthesia. 4. In the cream, ointments, sprays for surface anaesthesia. 5. It is also used in treatment of ventricular tachyarrthymias especially those associated with myocardial infarction Official preparation: # Lignocaine I.P, B.P, U.S.P # Lignocaine injection I.P, B.P, U.S.P # Lignocaine eyedrop I.P, B.P, # Lignocaine gel I.P, B.P,
  12. 12. PROCAINE (Novocaine, Ethocaine) ©Mr. Pankaj Kusum Ramdas Khuspe 4-amino-(2-diethyl amino ethyl) benzoate or 2-(Diethyl amino) ethyl-4-amino benzoate.
  13. 13. PROCAINE ©Mr. Pankaj Kusum Ramdas Khuspe Ethyl Benzoate N-diethyl amino Amino
  14. 14. PROCAINE ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is white crystalline powder 2. It is odorless. 3. It has slightly bitter taste. 4. It is very soluble in water. 5. It is freely soluble in alcohol. 6. It is very less soluble in chloroform. Storage: It should be stored in well closed container at a cool place away from direct sunlight.
  15. 15. PROCAINE ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as local anaesthetic. 2. It is primarily used for its local anaesthetic activity and used for : a) Infiltration b) Peripheral nerve block c) Spinal anaesthesia d) Producing regional analgesia 3. Its salt with benzyl penicillin is given to increase duration of action of benzyl penicillin. Official preparation: # Procaine I.P, B.P, U.S.P # Procaine Injection I.P, B.P Brand Names: Novocaine, Ethocaine, Novocane, Planocalne, Pronestyl
  16. 16. BENZOCAINE ©Mr. Pankaj Kusum Ramdas Khuspe Properties: 1. It is colorless crystals or white crystalline powder. 2. It is odorless. 3. It has a bitter taste. 4. It is very slightly soluble in water. 5. It is freely soluble in alcohol. 6. It is soluble in dilute acids. 7. It is affected by light Storage: It should be stored in well closed light resistant container at a cool place away from direct sunlight.
  17. 17. BENZOCAINE ©Mr. Pankaj Kusum Ramdas Khuspe Uses: 1. It is used as local anaesthetic. 2. It is used; a) To relieve pain associated with ulcers, wounds and mucous surface. b) To relieve pain of gastric carcinoma. c) For symptomic treatment of tuberculous Laryngitis d) To prevent nausea and vomitting.
  18. 18. BENZOCAINE ©Mr. Pankaj Kusum Ramdas Khuspe Official preparation: # Benzocaine I.P, B.P, U.S.P # Benzocaine Lozenges I.P, B.P, # Benzocaine ointments I.P, B.P # Benzocaine spray I.P, B.P # Benzocaine creams I.P, B.P # Benzocaine lotions I.P, B.P, # Benzocaine aerosol I.P, B.P Brand Names: Vicks formula 44, Soliwax ear, Healex spray.
  19. 19. Difference between Local & General Anesthesia Features General Anesthesia Local Anesthesia Definition General anaesthetics are the agents which bring about loss of all modalities of sensation, particularly pain, along with a reversible loss of consciousness. It may be defined as any substance applied topically or by localized injection or infiltration to dull or block pain sensation. Site of Action Central Nervous system Peripheral nerve Anesthesia produced on whole body Local Area (Site of Application) Consciousness Lost Not lost Prefer for Major surgery Minor Surgery Care of vital organs Essential Not much needed Induced either by #Inhalation #Parenteral #Topical #Parenteral Risk Factor High Comparatively low Use in non Possible Not possible
  20. 20. Any Question??? Thank you...

×