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Adrenaline(1)

Medication used in critical emergency

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Adrenaline(1)

  1. 1.   Stimulates α and β adrenoceptors  At low doses adrenaline has predominantly β adrenoceptor actions.
  2. 2.   Improves myocardial contractility (positive inotropic effect) as a result of increased influx of calcium into cardiac fibres.  Increases cardiac rate (positive chronotropic effect  Improve atrio-ventricular conduction (positive dromotropic effect).
  3. 3.   In low doses adrenaline decreases total peripheral vascular resistance and lower blood pressure  In large doses Adrenaline activates α receptors in the peripheral vascular system which increases resistance and raises blood pressure.  Net response is often vasodilation  Bronchodilation  Inhibits insulin secretion and decreases the uptake of glucose by peripheral tissues, thus raising blood glucose level.
  4. 4.   β-blockers such as proponolol, atenolol, bisoprolol, metoprolol etc.  Entacapone  Digitalis glycosides  Halogenated anaesthetics such as halothane, enflurane, isoflurane  Tricyclic antidepressants  Oxytocics Drug interactions
  5. 5.   Nervousness, restlessness, insomnia, tachycardia, tremors, sweating, hypertension, nausea, vomitting, pallor and weakness.  Entacapone  Digitalis glycosides  Halogenated anaesthetics such as halothane, enflurane, isoflurane  Tricyclic antidepressants, monoamine oxidase inhibitors antidepressants, cocaine  Oxytocics Adverse reactions
  6. 6.   Diabetes mellitus  Closed angle-glaucoma  Hypertension  Ischaemic heart disease  Hyperthyroidism  Parkinson’s disease
  7. 7.   Knights, K & Kathleen, B 2011, Pharmacology for health professionals, Chapter 12, Elsevier, Chatswood, Australia. REFERENCE

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