Mental health problems can emerge early in childhood and impair learning and behavior if left unaddressed. Significant adversity like abuse, neglect, poverty or family mental illness can damage the developing brain and increase risks for later mental health issues. While all children facing prolonged adversity are vulnerable, genetics also play a role - some children are more susceptible to stress. Early intervention can help address emerging problems and improve outcomes, but young children often express mental health issues differently than older children and adults due to differences in brain development, self-awareness and relationships. Untreated difficulties that start early may worsen over time into more serious disorders.
3. the issue
significant mental health problems can and do occur in young children. in some cases,
these problems can have serious consequences for early learning, social competence, and lifelong
health. Furthermore, the foundations of many mental health problems that endure through adult-
hood are established early in life through the interaction of genetic predispositions and sustained,
stress-inducing experiences. This knowledge should motivate practitioners and policymakers alike
to address mental health problems at their origins, rather than only when they become more seri-
ous later in life.
Public awareness of significant emotional and problems disrupt the typical pattern of devel-
behavioral problems in early childhood is oping brain architecture and impair emerging
growing, as preschool teachers report increas- capacities for learning and relating to others.
ingly major disruptions in their classrooms1 Most important, there are indications that
and kindergarten teachers identify social and early intervention can have a profound posi-
emotional problems as a common impedi- tive effect on the trajectory of emotional or
ment to school readiness.2,3 The emergence behavioral problems as well as improve out-
of mental health problems in young children comes for children with serious disorders, be
occurs within the context of an environment they psychological or genetic in origin.
of relationships that can include parents, rela- While all children experiencing prolonged
tives, caregivers, teachers, and peers. Science adversity are at risk for poor outcomes, studies
shows that this environment of relationships show that long-term physical and mental health
plays a critical role in shaping a child’s social, impacts are most likely to affect individuals who
emotional, and cognitive development in the are genetically more vulnerable to stress. Early
earliest years of life. In turn, problems in these stresses can include child abuse or neglect, fam-
domains affect not only the child, but those ily turmoil, neighborhood violence, extreme
who care for, play with, or attempt to teach
that child. Thus, while problems in cognitive
development are already the focus of much the foundations of many mental health problems
attention, emerging emotional and behavioral
problems in the early years are also an impor-
that endure through adulthood are established
tant societal issue that must be addressed.
early in life.
The science of early childhood development
also tells us that, for some children, mental
health problems may begin early and endure. poverty, and other conditions in a child’s envi-
Although establishing diagnostic criteria for ronment that can prime neurobiological stress
psychological disorders in young children re- systems to become hyper-responsive to adver-
mains a challenge, many children show clear sity.7 Exposure to adverse experiences such as
characteristics of anxiety disorders, attention- these early in life, particularly for vulnerable
deficit/hyperactivity disorder, conduct disor- children, predicts the emergence of later physi-
der, depression, post-traumatic stress disorder, cal and mental health problems, including psy-
and other problems at a very early age.4 Recent chological disorders like depression.8,9
reports suggest that some of the characteris- Although mental health challenges for young
tics of neuro-developmental disabilities such children share many biological and behavioral
as autism can be detected during the first year5 characteristics with those of older children and
and that older children often exhibit the emo- adults, there are at least three ways in which ear-
tional legacy of early abuse or neglect.6 Beyond ly childhood is a period of special vulnerability.
the challenges facing these children and their First, psychological health for young children is
caregivers, attention to early mental health strongly influenced by their environment of re-
problems is warranted because these kinds of lationships and the support or risks these rela-
www.developingchild.net Mental Health Problems in Early Childhood Can Impair Learning and Behavior for Life 1
4. national scientific council on the Developing chilD
tionships confer.10 Therefore, to understand the developmental differences are important to
reasons that young children may be at risk for understanding the behavioral and emotional
mental health impairments, how best to provide disturbances that young children may experi-
assistance, and strategies for preventing these ence, how they are manifested, and how to assist
problems from arising, it is important to look them.
at the quality of their early relationships. To a Third, there is a broad range of individual
greater extent than is true of older children and differences among young children that can
adults, viewing the child alone as the “patient” make it difficult to distinguish typical varia-
or the source of the problem can lead to costly tions in behavior from persistent problems, or
or ineffective policies and practices. normal differences in maturation from signif-
Second, young children often respond to icant developmental delays.11 Although many
emotional experiences and traumatic events in enduring mental health problems have their
ways that are very different from adults. They origins in the early years, many behavioral or
understand, manage, and talk about their ex- emotional difficulties in children and even
periences differently from adults. Their self- adolescents are transient.12,13,14 Thus, caution
awareness and capacity to think about is needed when evaluating an infant or young
their emotions and the events that trig- child for potential indicators of emotional or
ger them are not yet well-developed. These behavioral difficulty.
what science tells us
significant adversity early in life can damage such as maternal depression, also have well-
the architecture of the developing brain and documented effects on developing brain func-
increase the likelihood of significant mental tion in the early years.24, 25, 26, 27, 28
health problems that may emerge either early All of these situations are stressful for chil-
or years later.7, 15,16,17,18,19,20,21 Life circumstances dren. Persistent activation of biological stress re-
associated with family stress, such as persis- sponse systems leads to abnormal levels of stress
tent poverty, threatening neighborhoods, hormones that have the capacity to damage
and very poor child care conditions, elevate brain architecture if they do not normalize. In
the risk of serious mental health problems the absence of the buffering protection of sup-
and undermine healthy functioning in the portive relationships, these hormone levels can
early years.22 Early childhood adversity of this remain out of balance. Known as toxic stress,
kind also increases the risk of adult health this condition literally interferes with develop-
and mental health problems because of its ing brain circuits, and poses a serious threat to
young children, not only because it undermines
persistent poverty, threatening neighborhoods, their emotional well-being, but also because
it can impair a wider range of developmental
and very poor child care conditions elevate the outcomes including early learning, exploration
and curiosity, school readiness, and later school
risk of serious mental health problems. achievement.15,21,29,30,31,32,33,34,35
much impairment in mental health arises as a
enduring effects on the body and brain de- result of the interaction between a child’s ge-
velopment.23 Young children who experience netic predisposition and his or her exposure to
recurrent abuse or chronic neglect, regularly significant environmental adversity. Differences
witness domestic violence, or live in homes in individual behavioral styles (which child de-
permeated by parental mental health or velopment researchers call temperament) influ-
substance abuse problems are particularly ence the mental health consequences of early
vulnerable. Relationship-based conditions traumatic, abusive, or stressful experiences. A
contributing to early emotional difficulties, young child with a genetic predisposition to
2 Mental Health Problems in Early Childhood Can Impair Learning and Behavior for Life www.developingchild.net
5. what science tells us
fearfulness, for example, is more likely to de- be related to the development of more serious
velop anxiety or depression than a child with- problems later in life, as other studies show that
out that predisposition, but particularly in the children who are behaviorally inhibited show
context of harsh, inconsistent caregiving (per- different activation of brain regions related to
haps owing to the stresses of deep poverty, poor emotional withdrawal and fear than children
quality child care, or a depressed mother) rather whose behavior is more typical.39,40,41,42
than nurturing, sensitive care.
This nature-nurture interaction is illus- the behaviors and characteristics associated
trated in studies of behavioral inhibition, an with mental health problems in the earliest years
early-emerging pattern of fearful, withdrawn of life are often different from those seen in older
behavior that is a risk factor for later anxiety children and adults with psychological difficul-
problems.10,36 In a recent report, behavioral in- ties.43,44,45 Young children’s brains are not fully
hibition at age 7 was related to the interaction of developed and they do not respond to stressful
two influences: (a) a gene that is associated with events the way adults do. A toddler who is cop-
anxiety and fear in adults, and (b) the mother’s ing with trauma or the loss of a loved one acts
report that she lacked social support from oth- differently from a traumatized adolescent be-
ers, which is likely to be associated with stress cause of the different psychological capabilities,
for her children. In other words, the interaction emotional needs, and social experiences at each
of a genetic tendency toward anxiety along with age. Young children manifest the symptoms of
the experience of life stress best predicted which depression or post-traumatic stress disorder
children would remain behaviorally inhibited (PTSD) differently from young adults. Some
at age 7.37,38 Such behavioral inhibition may mental health problems, such as attachment-
mental health problems can occur across childhood
any Diagnosis
serious emotional Disorder
anxiety Disorder
age 2-5
Disruptive Behavior Disorder age 8-17
aDhD
Depression
0 5% 10% 15% 20% 25% 30%
percent of children
Source: Egger & Angold (2006)4
www.developingchild.net Mental Health Problems in Early Childhood Can Impair Learning and Behavior for Life 3
6. national scientific council on the Developing chilD
related disorders (i.e., profound disturbances Promising approaches for some early mental
in close relationships with caregivers), are spe- health challenges are well-described,60,61,62 yet
cific to early childhood. Thus, although adult they are not widely available. Other problems
diagnostic approaches can provide some guid- have been less well-studied in very young chil-
ance for understanding the kinds of problems dren. Nevertheless, many disorders can be pre-
that younger children may experience, new ap- vented before they begin through developmen-
proaches to assessment and diagnosis based on tally appropriate, high-quality early care and
the unique developmental needs and character- education, systems of support that assist parents
istics of young children are also necessary.45,46 and caregivers to provide warm and secure re-
Over the past few years, researchers have lationships and detect emotional problems be-
validated diagnostic criteria specific to young fore they become more resistant to change, and
children that are useful in identifying early public policies that help to ameliorate the physi-
cal, social, and economic conditions that cause
some families to struggle.
if young children are not provided appropriate
some individuals demonstrate remarkable re-
help, emotional difficulties that emerge early in silience in the face of early, persistent maltreat-
ment, trauma, and emotional harm, but there are
life can become more serious disorders over time.
limits to the capacity of young children to recover
psychologically from such adversity.63,64,65,66 Even
forms of depression, post-traumatic stress under circumstances in which children have been
disorder, autism, disruptive behavior disor- rescued from traumatizing circumstances and
ders, anxiety disorders, and attention deficit/ placed in exceptionally nurturing homes, devel-
hyperactivity disorder.4,47,48,49,50,51,52,53 Despite opmental improvements are often accompanied
these gains, however, the accurate identifica- by continuing problems in self-regulation, emo-
tion of serious mental health disorders dur- tional adaptability, relating to others, and self-
ing the first three to four years of life remains understanding. There also is evidence to suggest
a challenging task. As with older children that long-term physical health can be affected by
and adults, it is unwise to assume that early early life adversity in the form of increased risk of
problems can be classified simply into one heart disease, diabetes, hypertension, and other
category within a diagnostic system. In fact, physical ailments, as stressful experiences can
young children, like older children and adults, literally be “built” into the body and the brain.9
frequently experience multple prob- Generally speaking, when children overcome these
lems (known as“co-morbidity”), as il- burdens, they have been the beneficiaries of ex-
lustrated by the co-occurrence of depres- ceptional efforts on the part of supportive adults.
sion with oppositional-defiant disorders These findings underscore the importance of pre-
in early childhood or the increased preva- vention and timely intervention in circumstances
lence of depression or anxious emotional that put young children at serious psychological
problems in children with autism.4,54,55,56 risk.
if young children are not provided appropriate serious developmental disabilities can also be
help, emotional difficulties that emerge early associated with significant mental health impair-
in life can become more serious disorders over ments that are affected by experience and ame-
time.57,58,59 Early prevention strategies and efforts nable to intervention. Neuro-developmental dis-
to identify and treat emergent mental health orders, such as autism, fragile X syndrome, and
problems are likely to be more psychologically Down syndrome, for example, are the result of
beneficial and cost-effective than trying to treat strong genetic influences. Nevertheless, genet-
emotional difficulties after they become more ics is only part of the story. Although disorders
serious at a later age. This field urgently needs such as Down syndrome have a strong genetic
treatment strategies that are age-appropriate, etiology, mental health outcomes for these chil-
support the development of healthy relation- dren are also affected by the quality of care and
ships, and are consistent with scientific knowl- support they receive. The possibility of signifi-
edge about early psychological development. cant improvement in quality of life, as well as in
4 Mental Health Problems in Early Childhood Can Impair Learning and Behavior for Life www.developingchild.net
7. what science tells us
both cognitive and social functioning, as a result for many providers of child health services and
of prompt intervention provides a strong argu- early care and education who are faced with
ment for the early detection and treatment of children who present problematic behavior, the
these developmental disorders. This is becom- question of “when to worry” is paramount, yet
ing increasingly apparent with respect to early little evidence exists to answer that question
intervention for autism.67 definitively. Although early mental health prob-
lems can foreshadow enduring disorders, many
the powerful influences of early relationships il- difficulties are transient and disappear with
lustrate how much the emotional well-being of appropriate management and further matura-
young children is directly tied to the emotional tion.12,13,14 Generally speaking, clinical experts
functioning of their caregivers and the families
in which they live.68 When these relationships
are abusive, threatening, chronically neglect- the emotional well-being of young children is
ful, or otherwise psychologically harmful, they
are a potent risk factor for the development
directly tied to the emotional functioning of their
of early mental health problems. In contrast,
caregivers and the families in which they live.
when these relationships are reliably warm,
responsive, and supportive, they can actually
buffer young children from the adverse effects advise greater concern when children exhibit
of other stressors.19,63.69,70,71 It is essential to constellations of problems (e.g., persistent irri-
treat young children’s mental health problems tability, eating and sleeping problems, combined
within the context of their family, home, and with defiance) that lead to significant impair-
community environments. Stated simply, ad- ments (especially in age-appropriate behavioral
dressing the stressors affecting a child requires skills and relationships). Nevertheless, in the ab-
addressing the stressors on his or her family in sence of more extensive evidence on the natu-
order to ensure that the critical environment ral history of many mental health disorders, the
of relationships can be maximally supportive. “when to worry” problem remains a challenge.
popular misrepresentations of science
as the public devotes more attention to experiences in early childhood are not “forgot-
the relation between early brain development ten” — they are built into the architecture of
and the emotional well-being of young children, the developing brain and can have a sustained
the risk of misinformation and misleading or impact that extends well into the adult years,
irresponsible messages also grows. Within this especially when they are severe, persistent, and
context, it is essential that we distinguish scien- uncontrollable. Aversive family and community
tific fact from erroneous fiction. The following environments can have a similarly enduring
two misconceptions are particularly important emotional impact on young children when they
to set straight. are experienced as toxic stress and not buffered
by supportive relationships.
contrary to popular belief, young children can
and do experience serious emotional problems contrary to popular belief, young children liv-
that are comparable in severity to what we ob- ing in highly disadvantaged environments can
serve in older children and adults, and can have be protected from serious emotional or behav-
lasting effects. Although young children are not ioral consequences. Although such conditions
as psychologically sophisticated as adults, re- increase their risk for serious mental health
search on early childhood development shows problems, learning impairments, and long-term
that they are capable of experiencing peaks of physical illnesses, children who experience seri-
joy and elation as well as depths of grief, sadness, ous threats to their psychological health, such
hopelessness, intense anger, and rage. Contrary as those who are physically abused, chronically
to traditional views, highly negative emotional neglected, or emotionally traumatized, do not
www.developingchild.net Mental Health Problems in Early Childhood Can Impair Learning and Behavior for Life 5
8. national scientific council on the Developing chilD
inevitably develop significant mental illnesses. the context of stable, nurturing relationships
These children can be protected through the with supportive and skilled caregivers as well as
early identification of their emotional needs through preventive mental health services.64,66,72
and the provision of appropriate assistance in
the science-policy gap
the fact that young children can present professionals who are regularly involved in the
challenging behaviors is hardly news to the lives of infants, toddlers, and preschoolers often
adults who care for them. It is less well known lack the knowledge and skills that would help
that some serious behavior problems in the them identify the early signs of mental health
early years of life may be the first signs of po- problems as well as fully understand the conse-
tentially lifelong disorders that are preventable quences of family difficulties and parent mental
if treated at a young age. Very young children health problems for young children’s develop-
can experience significant impairments in their ment. These professionals include child care
mental health that are embedded in the archi- providers and preschool teachers (who are of-
tecture of their brains and may have life-long ten the first people outside the family to iden-
consequences, according to a rich and growing tify a child who has serious emotional difficul-
science base. Yet little attention has been paid to ties), physicians and other health care providers
the development and implementation of strate- (who often lack a sophisticated understanding
gies to identify children who are at risk for such of psychological development and early mental
problems and provide supports for them and health), paraprofessional home visitors, pro-
their families that will increase the probability gram administrators and personnel in social
of more favorable outcomes. This gap between service, child protection, early intervention, and
what we know and what we do is illustrated by welfare agencies, and others who regularly serve
the following three examples. families with young children.
antipsychotic prescriptions for children have increased five-fold
45
40
perscriptions per 1000 children
35
30
25
20
15
10
5
0
1995-1996 2001-2002
antipsychotic prescriptions for children ages 2-12
Source: Cooper et al. (2006)81
6 Mental Health Problems in Early Childhood Can Impair Learning and Behavior for Life www.developingchild.net
9. the science-policy gap
in most communities, mental health services for young as age three.74 In most cases, these medi-
young children and their families are often limit- cations for young children are prescribed “off
ed, of uneven quality, and difficult to access, and label,” which means that they have only been
there are few well-trained professionals with ex- approved for treating adults and that there are
pertise in early childhood mental health. Central no scientific data on their immediate or long-
to this problem is the need to close the gap be- term effects on child behavior or early brain
tween the numbers of young children exhibit- development.47 Until the relevant clinical stud-
ing emotional difficulties and/or problematic ies have been completed with the appropriate
behavior that cannot be managed adequately by
their parents and the number of personnel who
are skilled in effective intervention approaches sometimes the best intervention strategy for
that are uniquely suited to this group.
young children with serious behavioral or
there has been a dramatic increase in the use of
psychoactive drugs for young children with be-
emotional problems is to focus directly on the
havioral or mental health problems, despite the
fact that neither the efficacy nor safety of many
primary needs of those who care for them.
of these medications has been studied specifi-
cally in children at these early ages.47 A recent populations of young children, the use of such
report from the National Survey of Children’s medications must be viewed as experimental and
Health, for example, reported that children age their safety and effectiveness unknown.75,76,77,78
4-8 were more likely to be taking medication
for attention deficit/hyperactivity disorder than
older children and adolescents.73 Of even greater
concern, some studies have reported increasing
numbers of prescriptions for stimulant medi-
cations and antidepressants to treat children as
implications for policy and programs
the science of early childhood develop- al and behavioral needs of infants, toddlers, and
ment, including knowledge about the extent to preschoolers are best met through coordinated
which serious emotional problems are embed- services that focus on their full environment of re-
ded in the architecture of the developing brain, lationships. Multigenerational, family-centered
is sufficiently mature to support a number of approaches offer the most promising models
evidence-based implications for those who de- for preventing and treating mental health prob-
velop and implement policies that affect the lems in young children. These strategies range
health and well-being of young children. Both from providing information and support to ad-
public and private actions can prevent the kinds dress problematic child behavior to initiating
of adverse circumstances that are capable of de- therapeutic interventions to address significant
railing healthy development, as well as increase parent mental health or substance abuse prob-
the likelihood that effective supports and appro- lems, end domestic violence, or help families
priate therapeutic interventions (where needed) to cope with the burdens of persistent poverty.
will reduce the long-term consequences of early Indeed, sometimes the best intervention strat-
threats to a child’s mental health. The follow- egy for young children with serious behavioral
ing points are particularly worthy of thoughtful or emotional problems is to focus directly on
consideration. the primary needs of those who care for them.
However, most funding approaches to mental
Because young children’s emotional well-being health services are client-specific rather than
is tied so closely to the emotional status of their family-focused, and most programs aimed at
parents and non-family caregivers, the emotion- such “adult” problems as poverty, domestic
www.developingchild.net Mental Health Problems in Early Childhood Can Impair Learning and Behavior for Life 7
10. national scientific council on the Developing chilD
violence, or substance abuse do not take into sources that do not relate easily. These might
consideration the emotional well-being of the include early care and education, social service
children affected by them. More flexible ap- and welfare departments, health care, schools,
proaches to funding family-based preventive child welfare agencies, and early intervention
and therapeutic mental health services are programs, to name a few. Reducing barriers to
needed. greater coordination often requires attention to
a tangle of administrative obstacles. One exam-
therapeutic help for a young child with emotional ple would be a change in reimbursement regula-
or behavioral problems can be provided through tions to allow “mental health funds” to be used
a combination of home- and center-based to pay for specialized child care for a youngster
services involving parents, extended family with emotional and behavioral problems, rather
members, home visitors, providers of early care than restricting the funds to only “mental health
and education, and/or mental health profession- programs.”
als. The settings, partnerships, and targets of
therapeutic assistance for young children with mental health services for adults who are parents
mental health needs are much more diverse of young children would have broader impact if
than those for adults because their emotional they routinely included attention to the needs of
well-being is linked tightly to the quality of the children as well. Because of the close associ-
their relationships with the important people in ation between young children’s emotional well-
their lives. Effective intervention often requires being and the emotional health and functioning
the coordination of services from multiple of their caregivers,79 therapeutic assistance to
preschool explusions Decrease with access to mental health professionals
30%
percent of pre-k teachers reporting expulsions
25%
access to
psychologist/psychiatrist
20%
access to social worker
15%
10%
5%
0
unavailable on-call on-site or
regular visits
access to mental health professionals in preschools
Source: Gilliam (2005)1
8 Mental Health Problems in Early Childhood Can Impair Learning and Behavior for Life www.developingchild.net
11. implications for policy anD programs
a parent ought to include an automatic assess- (S-CHIP), early intervention services under Part
ment of any young children in the family to see C of the Individuals With Disabilities Education
how they are experiencing the emotional conse- Act (IDEA), child welfare programs, and mater-
quences of their parent’s problems. For exam- nal and child health initiatives.
ple, any physician treating a depressed mother
ought to understand the consequences of that cultural differences in attitudes and beliefs about
diagnosis for her young children and therefore behavior and mental health require sensitivity
assure that they receive careful examinations and respect for diversity as well as specialized
and appropriate intervention as needed. intervention skills. The mental health needs of
young children in families from different cul-
physicians and providers of early care and edu- tural and ethnic groups would benefit consid-
cation would be better equipped to understand erably from enhanced practitioner training and
and manage the behavioral problems of young flexible service models that incorporate greater
children if they had more appropriate profes-
sional training in this area and easier access to
child mental health professionals when they are
Broader attention to early childhood mental health
needed. Caregivers, teachers, and physicians are
requires attention to the quality of out-of-home
often the first to recognize serious emotional
difficulties in a child who is in their care, and care that children typically experience in the
on-site assistance from early childhood mental
health specialists can be particularly helpful in early years.
providing guidance about how best to respond
to the needs of the children, their parents, and
providers of early care and education. Preschool content representing a broad variety of cultures.
teachers with access to mental health con- Differences are widespread across a variety of
sultation, for example, are less likely to expel domains that affect approaches to the sensitive
children with behavioral problems from their issues of emotional well-being and mental health
programs.80 Some states have made progress in the early childhood years. These include how
in providing funds for early childhood mental children are taught to interpret and express
health consultations in early child-care settings, their experiences of fear, anger, and shame;
often through the coordination of diverse fund- parents’ attitudes toward discipline; the relative
ing streams. Broader attention to early child- reinforcement given to individual achievement
hood mental health requires attention to the versus interdependent behavior; attitudes about
quality of out-of-home care that children typi- mental health and mental illness; and accep-
cally experience in the early years. tance of therapeutic intervention for very young
children by non-family members; among many
a better coordinated infrastructure for funding other concerns. The shifting demographics of
mental health services for young children could the early childhood population in the United
provide a more stable and efficient vehicle for States make this a particularly compelling pri-
assuring access to effective prevention and ority for future planning. Finally, the effects
treatment programs. Consistent with both the of cultural assimilation for immigrant groups
science—physiological interrelations among across generations underscore the importance
the physical health, safety, and emotional well- of understanding individual differences within
being of young children—and recent federal cultural groups as well as continuous changes in
legislation regarding parity for coverage of cultural beliefs and practices over time.
health care for both physical and mental health
impairments, funding for early childhood men-
tal health services could be integrated more
effectively into a wide range of existing health
programs. Examples include Early and Periodic
Screening, Diagnosis and Treatment (EPSDT)
services under the Medicaid program, the
State Children’s Health Insurance Programs
www.developingchild.net Mental Health Problems in Early Childhood Can Impair Learning and Behavior for Life 9
12. national scientific council on the Developing chilD
references
1 Gilliam, W. (2005). Prekindergarteners left behind: 15 Carrion, V., Weems, C., Ray, R., Glaser, B., Hessl, D., &
Expulsion rates in state prekindergarten systems. New Reiss, A. (2002). Duirnal salivary cortisol in pediatric
Haven, CT: Yale University Child Study Center. posttraumatic stress disorder. Biological Psychiatry, 51,
2 Lewit, E., & Baker, L. (1995). School readiness. The 575-582.
Future of Children, 5, 128-139. 16 De Bellis, M., Baum, A., Birmaher, B., Keshavan, M.,
3 Rimm-Kaufman, S., Pianta, R., & Cox, M. (2000). Eccard, C., Boring, A., Jenkins, F., & Ryan, N. (1999).
Teachers’ judgments of problems in the transition to Developmental traumatology, Part 1: Biological stress
kindergarten. Early Childhood Research Quarterly, 15, systems. Biological Psychiatry, 9, 1259-1270.
147-166. 17 De Bellis, M., Keshavan, M., Clark, D., Casey, B.,
4 Egger, H. L., & Angold, A. (2006). Common emotional Giedd, J., Boring, A., Jenkins, F., & Ryan, N. (1999).
and behavioral disorders in preschool children: Developmental traumatology, Part 2: Brain development.
Presentation, nosology, and epidemiology. Journal of Biological Psychiatry, 45, 1271-1284.
Child Psychology and Psychiatry, 47, 313-337. 18 Glaser, D. (2000). Child abuse and neglect and the brain:
5 Yirmiya, N., & Ozonoff, S. (2007). The very early A review. Journal of Child Psychology and Psychiatry, 41,
autism phenotype. Journal of Autism and Developmental 97-118.
Disorders (Special Issue), 37, 1-11. 19 Gunnar, M.R., Morison, S.J., Chisholm, K., & Schuder,
6 Teisl, M., & Cicchetti, D. (2008). Physical abuse, cognitive M. (2001). Salivary cortisol levels in children adopted
and emotional processes, and aggressive/disruptive from Romanian orphanages. Development and
behavior problems. Social Development, 17, 1-23. Psychopathology, 13, 611-628.
7 Gunnar, M.R. (2007). Stress effects on the developing 20 Kaufman, J., & Charney, D. (2001). Effects of early
brain. In D. Romer, E.F. Walker (Eds.) Adolescent stress on brain structure and function: Implications
psychopathology and the developing brain: Integrating for understanding the relationship between child
brain and prevention science. (pp. 127-147). New York: maltreatment and depression. Development and
Oxford University Press. Psychopathology, 13, 451-471.
8 Edwards, V. J., Holden, G. W., Felitti, V. J., & Anda, R.F. 21 National Scientific Council on the Developing Child.
(2003). Relationship between multiple forms of child (2005). Excessive Stress Disrupts the Architecture of the
maltreatment and adult mental health in community Developing Brain, Working Paper #3. Retrieved 12/19/07
respondents: Results from the Adverse Childhood from http://www.developingchild.net/reports.shtml.
Experiences Study. American Journal of Psychiatry, 160, 22 Brooks-Gunn, J., & Duncan, G.J. (1997). The effects of
1453-1460. poverty on children. The Future of Children, 7, 55-71.
9 Felitti, V. J., Anda, R. F., Nordenberg, D., Williamson, D. 23 Danese, A., Pariante, C. M., Caspi, A., Taylor, A., &
F., Spitz, A. M., Edwards, V., Koss, M. P., & Marks, J. S. Poulton, R. (2007). Childhood maltreatment predicts
(1998). Relationship of childhood abuse and household adult inflammation in a life-course study. Proc. Natl.
dysfunction to many of the leading causes of death in Acad. Sci. USA, 104:1319-1324.
adults: The Adverse Childhood Experiences (ACE) study. 24 Danese, A., Moffitt, T. E., Pariante, C. M., Ambler, A.,
American Journal of Preventive Medicine, 14, 245-258. Poulton, R., & Caspi, A. (2008). Elevated inflammation
10 Rubin, K., Bukowski, W., & Parker, J. (2006). Peer levels in depressed adults with a history of childhood
interactions, relationships, and groups. In W. Damon maltreatment. Arch. Gen. Psychiat. 2008; 65:409-416.
& R. M. Lerner (Eds.), Handbook of child psychology 25 Dawson, G., Ashman, S., Panagiotides, H., Hessl, D., Self,
(6th Ed.), Vol. 3. Social, emotional, and personality J., Yamada, E., & Embry, L. (2003). Preschool outcomes
development (N. Eisenberg, Vol. Ed.) (pp. 571-645). New of children of depressed mothers: role of maternal
York: Wiley. behavior, contextual risk, and children’s brain activity.
11 Shonkoff, J. P., & Phillips, D. A. (Eds.) (2000). From Child Development, 74, 1158-1175.
neurons to neighborhoods: The science of early childhood 26 Evans, G. W., Gonnella, C., Marcynyszyn, L. A., Gentile,
development. Washington, DC: National Academy Press. L., & Salpekar, N. The role of chaos in poverty and
12 Peterson, B. S., Pine, D. S., Cohen, P., & Brook, J. S. children’s socioemotional adjustment. Psycholigical
(2001). Prospective, longitudinal study of tic, obsessive- Science. 2004; 16:560-565.
compulsive, and attention-deficit/hyperactivity disorders 27 Evans, G. W., Kim, P., Ting, A. H., Tesher, H. B., &
in an epidemiological sample. Journal of the American Shannis, D. Cumulative risk, maternal responsiveness,
Academy of Child & Adolescent Psychiatry, 40, 685-695. and allostatic load among young adolescents.
13 Pine, D. S., Cohen, P., Johnson, J. G., & Brook, J. S. Developmental Psychology. 2007; 43:341-351
(2002). Adolescent life events as predictors of adult 28 Goodman, S., & Gotlib, I. (1999). Risk for
depression. Journal of Affective Disorders, 68, 49-57. psychopathology in the children of depressed mothers: a
14 Pine, D. S., Cohen, P., Gurley, D., Brook, J., & Ma, Y. developmental model for understanding mechanisms of
(1998). The risk for early-adult anxiety and depressive transmission. Psychological Review, 3, 458-490.
disorders in adolescents with anxiety and depressive
disorders. Archives of General Psychiatry, 55, 56-64.
10 Mental Health Problems in Early Childhood Can Impair Learning and Behavior for Life www.developingchild.net
13. references
29 Dawson, G,. & Ashman, D. (2000). On the origins 43 Doll, B., Brehm, K., Zucker, S., Deaver-Langevin, J.,
of a vulnerability to depression: The influence of Griffin, J., & Hickman, A. (2000). Contrasting procedures
the early social environment on the development of for empirical support of traditional and population-
psychobiological systems related to risk of affective based mental health services. Psychology in the Schools,
disorder. In C.A. Nelson (Ed.), The effects of early 37, 431-442.
adversity on neurobehavioral development. Minnesota 44 Lieberman, A.F., Barnard, K.E., Wieder, S. (2004)
Symposia on Child Psychology, Vol. 31 (pp. 245-279). Diagnosing infants, toddlers, and preschoolers: The Zero
Mahwah, NJ: Erlbaum. to Three diagnostic classification of early mental health
30 Luby, J., Belden, A., & Spitznagel, E. (2006). Risk factors disorders. In R. DelCarmen-Wiggins, & A. Carter (Eds.),
for preschool depression: the mediating role of early Handbook of infant, toddler, and preschool mental health
stressful life events. Journal of Child Psychology and assessment (pp141-160).
Psychiatry, 47,1292-1298. 45 Zero to Three. (2005). DC:0-3R: Diagnostic classification
31 Osofsky, J. (2004). Community outreach for children of mental health and developmental disorders of infancy
exposed to violence. Infant Mental Health Journal, 25, and early childhood (rev. edu). Washington, DC, US:
478-487. Zero to Three National Center for Infants, Toddlers and
32 Rubin, K., Burgess, K., Dwyer, K., & Hastings, P. (2003). families.
Predicting preschoolers’ externalizing behaviors from 46 American Academy of Child & Adolescent Psychiatry
toddler temperament, conflict, and maternal negativity. (AACAP) (2003). Research diagnostic criteria for infants
Developmental Psychology, 39,164-176. and preschool children: The process and empirical
33 Scheeringa, M., & Zeanah, C. (1995). Symptom support. Journal of the American Academy of Child &
expression and trauma variables in children under 48 Adolescent Psychiatry, 42, 1504-1512.
months of age. Infant Mental Health Journal, 16, 259-270. 47 Gleason, M. M., Egger, H. L., Emslie, G. J., Greenhill, L.
34 Shaw, D., Owens, E., Giovannelli, J.,& Winslow, E. L., Kowatch, R. A., Lieberman, A. F., Luby, J. L., Owens, J.,
(2001). Infant and toddler pathways leading to early Scahill, L. D., Scheeringa, M. S., Stafford, B., Wise, B., &
externalizing disorders. Journal of the American Academy Zeanah, C. H. (2007). Psychopharmacological treatment
of Child & Adolescent Psychiatry, 40, 36-43. for very young children: Contexts and guidelines.
35 Vasey, M., & Dadds, M. (2001). The developmental Journal of the American Academy of Child & Adolescent
psychopathology of anxiety. London: Oxford University Psychiatry, 46, 1532-1572.
Press. 48 Keenan, K., & Wakschlag, L. S. (2002). Can a valid
36 Tincas, I., Benga, O., & Fox, N. (2006). Temperamental diagnosis of disruptive behavior disorder be made in
predictors of anxiety disorders. Cognition, Brain, preschool children? American Journal of Psychiatry, 159,
Behavior, 10, 489-515. 351-358.
37 Fox, N., Hane, A., & Pine, D. (2007). Plasticity for 49 Luby, J. L. (Ed.) (2006). Handbook of preschool mental
affective neurocircuitry: How the environment affects health: Development, disorders, and treatment. New York:
gene expression. Current Directions in Psychological Guilford.
Science, 16, 1-5. 50 Luby, J. L., Mrakotsky, C., Heffelfinger, A., Brown, K.,
38 Fox, N., Nichols, K., Henderson, H., Rubin, K., Schmidt, Hessler, M., Spitznagel, E. (2003). Modification of DSM-
L., Hamer, D., Ernst, M., & Pine, D. (2005). Evidence for IV criteria for depressed preschool children. American
a gene-environment interaction in predicting behavioral Journal of Psychiatry, 160, 1169-1172.
inhibition in middle childhood. Psychological Science, 16, 51 Lord, C., Risi, S., DiLavore, P. S., Schulman, C., Thurm,
921-926. A., & Pickles, A. (2006). Autism from 2 to 9 years of age.
39 Fox, N., Henderson, H., Marshall, P., Nichols, K., & Archives of General Psychiatry, 63, 694-701.
Ghera, M. (2005). Behavioral inhibition: Linking biology 52 Scheeringa, M., Peebles, C. D., Cook, C. A., & Zeanah,
and behavior within a developmental framework. Annual C. H. (2001). Toward establishing procedural, criterion,
Review of Psychology, 56, 235-262. and discriminant validity for PTSD in early childhood.
40 Fox, N., Henderson, H., Rubin, K., Calkins, S., & Journal of the American Academy of Child & Adolescent
Schmidt, L. (2001). Continuity and discontinuity Psychiatry, 40, 522-60.
of behavioral inhibition and exuberance: 53 Scheeringa, M., Zeanah, C. H., Myers, L., & Putnam, F.
Psychophysiological and behavioral influences across the (2005). Predictive validity in a prospective follow-up
first four years of life. Child Development, 72, 1-21. of PTSD in preschool children. Journal of the American
41 Pine, D. S. (2007). Research review: A neuroscience Academy of Child & Adolescent Psychiatry, 44, 899-906.
framework for pediatric anxiety disorders. Journal of 54 Ghaziuddin, M., Ghaziuddin, N., & Greden, J. (2002).
Child Psychology and Psychiatry, 48, 631-648. Depression in persons with autism: Implications
42 Schwartz, C., Wright, C., Shin, L., Kagan, J., & Rauch, for research and clinical care. Journal of Autism and
S. (2003). Inhibited and uninhibited infants “grown Developmental Disorders, 32, 299-306.
up”: Adult amygdalar response to novelty. Science, 300,
1952-1953.
www.developingchild.net Mental Health Problems in Early Childhood Can Impair Learning and Behavior for Life 11
14. national scientific council on the Developing chilD
55 Ghaziuddin, M., & Greden, J. (1998). Depression in 70 Francis, D., Diorio, J., Plotsky, P.M., & Meaney, M.J.
children with autism/pervasive developmental disorders: (2002). Environmental enrichment reverses the effects
A case-control family history study. Journal of Autism of maternal separation on stress reactivity. Journal of
and Developmental Disorders, 28, 111-115. Neuroscience, 22, 7840-7843.
56 Kim, J.A., Szatmari, P., & Bryson, S.E. (2000). The 71 Sweeney, G.M. (2007). Why childhood attachment
prevalence of anxiety and mood problems among matters: Implications for personal happiness, families
children with autism and Asperger syndrome. Autism, 4, and public policy. In A.S. Loveless, & T.B. Holman (Eds.),
117-132. The family in the new millennium: World voices supporting
57 Keenan, K., Shaw, D., & Delliquadri, E. (1998). the “natural” clan, Vol 1 (332-346). Westport, CT: Praeger
Evidence for the continuity of early problem behaviors: Publishers/Greenwood Publishing Group..
Application of a developmental model. Journal of 72 Melton, G.B., Thompson, R.A., & Small, M.A. (2002).
Abnormal Child Psychology, 26, 441-452. Toward a child-centered, neighborhood-based child
58 Shaw, D.S., Gilliom, M., & Ingoldsby, E.M. (2003). protection system: A report of the consortium on children,
Trajectories leading to school-age conduct problems. families, and the law. Westport, CT: Praeger Publishers/
Developmental Psychology, Special issue: Violent Greenwood Publishing Group.
Children, 39, 189-200. 73 Visser, S. N., Lesesne, C. A., & Perou, R. (2007). National
59 Suveg, C., Southam-Gerow, M.A., & Goodman, K.L. estimates and factors associated with medication
(2007). The role of emotion theory and research in child treatment for childhood attention-deficit/hyperactivity
therapy development. Clinical Psychology: Science and disorder. Pediatrics, 119, 99-106.
Practice, 14, 358-371. 74 Zito, J.M., Safer, D.J., dosReis, S., Gardner, J.F., Boles, M., &
60 Lieberman, A. F., Ippen, C. G., & Van Horn, P. (2006). Lynch, F. (2000). Trends in the prescribing of psychotropic
Child-parent psychotherapy: 6-month follow-up of a medications to preschoolers. Journal of the American
randomized controlled trial. Journal of the American Medical Association, 283(8), 1025-1030.
Academy of Child & Adolescent Psychiatry, 45, 913-918, 75 Carlezon Jr., W.A., & Konradi, C. (2004). Understanding
61 Peterson, C.A., Luze, G.J., & Eshbaugh, E.M. (2007). the neurobiological consequences of early exposure to
Enhancing parent-child interactions through home psychotropic drugs: Linking behavior with molecules.
visiting: Promising practice or unfulfilled promise? Neuropharmacology, 47, 47–60.
Journal of Early Intervention, 29, 119-140. 76 Carlezon, Jr., W.A., Mague, S.D., & Andersen, S.L.
62 Sameroff, A.J., McDonough, S.C., & Rosenblum, K.L. (2003). Enduring behavioral effects of early exposure to
(2004). Treating parent-infant relationship problems: methylphenidate in rats. Belmont: Society of Biological
Strategies for intervention. New York, NY: Guilford Press. Psychiatry.
63 Graham-Berman, S.A., & Hughes, H.M. (2003). 77 Bairy, K.L., Madhyastha, S., Ashok, K.P., Bairy, I., &
Intervention for children exposed to interparental Malini, S. (2006). Developmental and behavioral
violence (IPV): Assessments of needs and research consequences of prenatal fluoxetine. Pharmacology, 79,
priorities. Clinical Child & Family Psychology Review, 6, 1–11.
189-204. 78 Ashman, S., & Dawson, G. (2002). Maternal depression,
64 Judge, S. (2004). The impact of early institutionalization infant psychobiological development, and risk for
on child and family outcomes. Adoption Quarterly, 7, depression. In S.H. Goodman & I.H. Gotlib (Eds.),
31-48. Children of depressed parents (pp. 37-58). Washington,
65 Lowenthal, B. (2001). Abuse and neglect: The educator’s DC: American Psychological Association.
guide to the identification and prevention of child 79 Lesesne, C. A., Visser, S. N., & White, C. P. (2003).
maltreatment. Baltimore, MD: Paul H. Brookes Attention-deficit/hyperactivity disorder in school-aged
Publishing. children: Association with maternal mental health and
66 Watts-English, T., Fortson, B.L., & Gibler, N. (2006). The use of health care resources. Pediatrics, 111, 1232-1237.
psychobiology of maltreatment in childhood. Journal of 80 Gilliam, W., & Zigler, E.F. (2000). A critical meta-analysis
Social Issues, 62, 717-736. of all evaluations of state-funded preschool from 1977
67 Faja, S., & Dawson, G. (2006). Early intervention for to 1998: Implications for policy, service delivery and
autism. In J. Luby (Eds.) Handbook of preschool mental program evaluation. Early Childhood Research Quarterly,
health (pp. 388-416). New York: Guilford. 15, 441-473.
68 National Scientific Council on the Developing Child. 81 Cooper, W.O., Arbogast, P.G., Ding, H., Hickson, G.B.,
(2004). Young children develop in an environment of Fuchs, D.C., & Ray, W.A. (2006). Trends in prescribing of
relationships, Working Paper #1. Retrieved 12/19/07 from antipsychotic medications for US children. Ambulatory
http://www.developingchild.net/reports.shtml. Pediatrics, 6, 79-83.
69 Bredy, T.W., Humpartzoomian, R.A., Cain, D.P., &
Meaney, M.J.P. (2003). Partial reversal of the effect
of maternal care on cognitive function through
environmental enrichment. Neuroscience, 118, 571-576.
12 Mental Health Problems in Early Childhood Can Impair Learning and Behavior for Life www.developingchild.net
15.
16. council working paper series
working paper #1
Young Children Develop in an Environment of Relationships (2004)
http://developingchild.net/pubs/wp-abstracts/wp1.html
working paper #2
Children’s Emotional Development is Built into the Architecture of their Brain (2004)
http://developingchild.net/pubs/wp-abstracts/wp2.html
working paper #3
Excessive Stress Disrupts the Architecture of the Developing Brain (2005)
http://developingchild.net/pubs/wp-abstracts/wp3.html
working paper #4
Early Exposure to Toxic Substances Damages Brain Architecture (2006)
http://developingchild.net/pubs/wp-abstracts/wp4.html
working paper #5
The Timing and Quality of Early Experiences Combine to Shape Brain Architecture (2007)
http://developingchild.net/pubs/wp-abstracts/wp5.html
also from the council
A Science-Based Framework for Early Childhood Policy: Using Evidence to Improve
Outcomes in Learning, Behavior, and Health for Vulnerable Children (2007)
http://developingchild.net/pubs/pubs.html
The Science of Early Childhood Development: Closing the Gap Between What We Know
and What We Do (2007)
http://developingchild.net/pubs/pubs.html
50 Church Street, 4th Floor, Cambridge, MA 02138
617.496.0578
www.developingchild.net
www.developingchild.harvard.edu