1. Loreto B. Ong, MD, FPSCRS Colorectal Surgery Department of General Surgery Vicente Sotto Memorial Medical Center

7. Adenoma – Carcinoma Sequence MUTATIONS

18. Prognosis Cancer Staging 5 year survival Stage I 70 -95 % Stage II 54 – 65% Stage III 39 – 60% Stage IV 0 – 16%

19. Prognosis ……… UNFORTUNATELY Cancer Staging 5 year survival Stage I 70 -95 % Stage II 54 – 65% Stage III 39 – 60% Stage IV 0 – 16%

21. Treatment Cancer Staging Treatment Stage I Surgery Stage II Surgery Stage III Surgery + Chemotherapy Stage IV Surgery + Chemotherapy; Palliation

25. Screening Guidelines Population Initial Age Recommended Screening Tool Average Risk 50 yo Annual FOBT Flexible sigmoidoscopy every 5 years Annual FOBT with Flexible sigmoidoscopy every 5 years Air contrast barium enema every 5 years Colonoscopy every 10 years