Drug information retrieval & storage: By RxvichuZ!

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This work deals with Drug Information Retrieval & Storage(DIRS): Related to Biostatistics & Research Methodology Subject. Just provides a brief insight into the topic. Regards, @ RxVichuZ! :)

Health & Medicine

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The hospital pharmacy may be defined as that department of the hospital that deals with procurement, storage, compounding, dispensing, manufacturing, testing, packaging, and distribution of drugs. It is also concerned with education and research in pharmaceutical services. A hospital pharmacy is controlled by a qualified pharmacist. The hospital pharmacy exerts a great deal of influence on the professional status of the hospital as well as the economics of the total operational cost of the institution. Modern-day hospital pharmacy also provides clinical pharmacy services of drug monitoring and drug information system.

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PARUL UNIVERSITY

1. Measurement of Bioavailability: Direct and indirect methods may be used to assess drug bioavailability. The in-vivo bioavailability of a drug product is demonstrated by the rate and extent of drug absorption, as determined by comparison of measured parameters, e.g., concentration of the active drug ingredient in the blood, cumulative urinary excretion rates, or pharmacological effects. For drug products that are not intended to be absorbed into the bloodstream, bioavailability may be assessed by measurements intended to reflect the rate and extent to which the active ingredient or active moiety becomes available at the site of action. The design of the bioavailability study depends on the objectives of the study, the ability to analyze the drug (and metabolites) in biological fluids, the pharmacodynamics of the drug substance, the route of drug administration, and the nature of the drug product. Pharmacokinetic and/or pharmacodynamic parameters as well as clinical observations and in-vitro studies may be used to determine drug bioavailability from a drug product. 1.1. Pharmacokinetic methods: These are very widely used and based upon the assumption that the pharmacokinetic profile reflects the therapeutic effectiveness of a drug. Thus these are indirect methods. The two major pharmacokinetic methods are: The major pharmacokinetic methods are:  Plasma / blood level time profile. o Time for peak plasma (blood) concentration (t max) o Peak plasma drug concentration (Cmax) o Area under the plasma drug concentration–time curve (AUC)  Urinary excretion studies. o Cumulative amount of drug excreted in the urine (Du) o Rate of drug excretion in the urine (dDu/dt) o Time for maximum urinary excretion (t)  C. Other biological fluids 1.2. Pharmacodynamic methods: IT involves direct measurement of drug effect on a (patho) physiological process as a function of time. Disadvantages of it may be high variability, difficult to measure, limited choices, less reliable, more subjective, drug response influenced by several physiological & environmental factors. They involve determination of bioavailability from:  Acute pharmacological response.  Therapeutic response. 1.3. In-vitro dissolution studies  Closed compartment apparatus  Open compartment apparatus  Dialysis systems. 1.4. Clinical observations  Well-controlled clinical trials

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