Lara Mangravite WBBA Life Science 2011-06-15

Lara Mangravite, June 15, 2011. WBBA Life Science Leadership Meeting, Spokane, WA

Health & Medicine

Lara Mangravite, PhD

To create an open access, integrative bionetwork evolved by contributor
scientists working to eliminate human disease.
Non-coding RNA network

protein network
ENVIRONMENT

metabolite network

transcriptional network

Sharing: Disease biology is too complicated to be solved by any one
group using one dataset.
Collaboration: Science is most successful when smart people with
varied expertise come together to solve a problem.

An open source, community-based genomic compute space:
Synapse

Collaborative Research Community Opinion
Biological
and
Clinical
Validation

Data1
Results1
Model1

Data2
Results2
Model2

Platform Launch: Fall 2011

Think Global, Act Local!

The Washington Partners Program:
Improve biomedical research in WA through research
partnerships

2011 partner projects:
Amgen: Biomarkers of drug-induced liver toxicity
Seattle Children’s Hospital: Mechanisms for development of craniosynostosis
Presage Biosciences: Drug targets for prostate cancer

Collaborations are funded through a grant from:

2012 Partners Proposals
October 1st 2011

www.sagebase.org/wpp

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Analysis Analysis Analysis Analysisof the entire entire entire protein protein proteinproteincomplementcomplement complement complement of acell, cell, tissue, tissue, tissue, or organism organism organism under under aspecific, specific, specific, defined defined set of conditions conditions conditions . • Relies Relies Relies on 3basic technological technological technological technological technological cornerstones cornerstones cornerstones cornerstones • MethodMethod MethodMethod to fractionatefractionate fractionatefractionate fractionatefractionate complexcomplex complex protein/protein/ protein/ protein/ peptide peptide peptidemixturesmixtures mixtures • MS to acquire acquire the data data necessary necessary to identify identify identifyidentifyindividual individual individual individualproteins proteins • Bioinformatics Bioinformatics Bioinformatics Bioinformatics Bioinformatics Bioinformatics Bioinformaticsto analyze analyze and assemble assemble the MS data

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The diagnosis of viral pathogens is a crucial component of plant biosecurity surveillance and preventing the introduction of exotic plant viruses and viroids at the border. Existing quarantine procedures can be time-consuming and require detailed knowledge of potential infecting viral pathogens. Currently, imported plants can spend as long as two years in quarantine, with associated costs. To simplify the post-entry quarantine process researchers have developed a plant diagnostic toolkit for plant viruses and viroids. The toolkit takes advantage of the natural antiviral system of plants, using small RNA next generation sequencing (sRNA-seq) technology to detect nearly all known viruses and viroids in a single test. The new test, and associated toolkit, will reduce the time imported plant material spends in Australia’s quarantine system while improving accuracy of detection in a single sRNA-seq experiment.

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