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Everything you wanted to know about
DNA, via Bauhinia flowers
What is molecular biology?
http://biology.clc.uc.edu/fankhauser/labs/genetics/dna_isolation/thymus_dna.htm
What do we know about DNA?
Watson & Crick (based on data from Franklin) crack structure
The language of heredity & evolution
Watson & Crick (based on data from Franklin) crack structure
http://www.ck12.org/book...
The language of heredity & evolution
Watson & Crick (based on data from Franklin) crack structure
http://www.bbc.co.uk/sch...
What do we know about DNA?
How many letters (bases) in the Human Genome?
What do we know about DNA?
How many letters (bases) in the Human Genome?
3 billion basepairs (3Gbp, or 6Gbp if you count w...
What do we know about DNA?
How many letters (bases) in the Human Genome?
3 billion basepairs (3Gbp, or 6Gbp if you count w...
What do we know about DNA?
How many letters (bases) in the Human Genome?
3 billion basepairs (3Gbp, or 6Gbp if you count w...
What do we know about DNA?
How many letters (bases) in the Human Genome?
3 billion basepairs (3Gbp, or 6Gbp if you count w...
What do we know about DNA?
How many letters (bases) in the Human Genome?
3 billion basepairs (3Gbp, or 6Gbp if you count w...
Fred Sanger figures out how to read DNA…
http://www.cambridge.org/asia/catalogue/catalogue.asp?is
bn=9781107083349
So we decided to read it all!
Source: http://www.genome.gov/Images/press_photos/highres/38-300.jpg
Human Genome Project: 1...
Post-Human Genome Project
1st Gen
2nd (next) Gen
Source: http://www.genome.gov/sequencingcosts/
Now at $1,000!
Sequencing in the field & clinic for biodiversity studies and
medical testing.
Produces real-time data, can diagnose infec...
So many things you can do with
sequencing…study biodiversity
http://www.sciencedirect.com/science/article/pii/S00063207140...
So many things you can do with
sequencing…study microbiome
You have more microbe than human cells (up to 10x more).
So many things you can do with
sequencing…study ancient DNA
http://www.nature.com/news/dna-has-a-521-year-half-life-1.1155...
We don’t just read
DNA now…
Synthetic Biology &
Genome Editing
From K Chow
Meet Synthia
http://www.bbc.com/news/10134341
Meet Synthia
The first genome designed by computer.
July 2, 2010
What would you like to make with synthetic DNA?
How far should this work go? Any ethical concerns?
GENOMICS IN HONG KONG
BGI HK “Chamber O’Illumina’s”
Brought HK the worlds largest sequencing
Genomics: something we are good at
http://www.theguardian.com/science/2013/sep/01/dennis-lo-prenatal-research-cancer
Why is important?
Need people to handle the biggest, "big data"
Big Data: Astronomical or Genomical?
http://journals.plos....
Need to build skills & awareness in HK
Brought to you by: HK CUHK
…and the people of Hong Kong
An emblematic genome project
A historical mystery that needs solving
?
Botanical & Afforestation
Department, 1903: "The mysterious
origin of the tree a...
Hybrids: like a Liger?
https://en.wikipedia.org/wiki/Liger#/media/File:Liger_couple.jpg
The Hong Kong Orchid: not an orchid
An icon that needs protecting
Susceptibility to disease?
Other uses for Bauhinia?
Latin name
Common
name
(Nepal) Edible use Other use
Bauhinia
purpurea Tanki
Flowers and young sho...
Tasty Emblem? Eaten in Nepal
Recipe: http://bauhiniagenome.hk/get-involved/education/recipe-koirala-achaar/
Help needed assembling the puzzle
600M bp genome
Tricky hybrid genome
Need to assemble
parents first
Chemicals cost
$10,00...
With Parts Made in (BGI) Hong Kong
A project that needs supporting
@bauhiniagenome #bauhinawatch
https://www.facebook.com/BauhiniaGenome
http://bauhiniagenom...
#bauhiniawatch
http://bauhiniagenome.hk/wp-content/uploads/2015/11/Bauhinia-identification-
table.pdf
#bauhiniawatch
http://bauhiniagenome.hk/2015/12/bauhinia-watch-the-movie/
Extract your own DNA – how to guide
http://learn.genetics.utah.edu/content/labs/extraction/howto/
http://www.stevespangler...
Any Questions?
Extra discussion: Is Bauhinia a GMO?
http://www.geneticliteracyproject.org/2014/06/19/how-your-food-would-look-if-not-genetically-modified-over-millennia/
In a...
Hybrids are key to agriculture
http://www.slideshare.net/hannahreed/selective-breeding-powerpoint
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Bauhina Genome slides for school visit

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BauhinaGenome.hk slides used for a school visit to talk DNA, genomics and Bauhinia to year 6 (11-12 year old) science class at the CIS school in Hong Kong.

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Bauhina Genome slides for school visit

  1. 1. Everything you wanted to know about DNA, via Bauhinia flowers
  2. 2. What is molecular biology? http://biology.clc.uc.edu/fankhauser/labs/genetics/dna_isolation/thymus_dna.htm
  3. 3. What do we know about DNA? Watson & Crick (based on data from Franklin) crack structure
  4. 4. The language of heredity & evolution Watson & Crick (based on data from Franklin) crack structure http://www.ck12.org/book/CK-12-Biology/section/8.1/ http://www.bbc.co.uk/schools/gcsebitesize/science/add_ocr_pre_2011/growth_develop ment/genesrev1.shtml
  5. 5. The language of heredity & evolution Watson & Crick (based on data from Franklin) crack structure http://www.bbc.co.uk/schools/gcsebitesize/science/add_ocr_pre_2011/growth_develop ment/genesrev1.shtml Not binary code (1+0), but 4 bases 64 combinations for 20 amino acids
  6. 6. What do we know about DNA? How many letters (bases) in the Human Genome?
  7. 7. What do we know about DNA? How many letters (bases) in the Human Genome? 3 billion basepairs (3Gbp, or 6Gbp if you count we are diploid)
  8. 8. What do we know about DNA? How many letters (bases) in the Human Genome? 3 billion basepairs (3Gbp, or 6Gbp if you count we are diploid) Stretching it out, how long would all the DNA in a (10μm) cell be?
  9. 9. What do we know about DNA? How many letters (bases) in the Human Genome? 3 billion basepairs (3Gbp, or 6Gbp if you count we are diploid) Stretching it out, how long would all the DNA in a (10μm) cell be? 2m long
  10. 10. What do we know about DNA? How many letters (bases) in the Human Genome? 3 billion basepairs (3Gbp, or 6Gbp if you count we are diploid) Stretching it out, how long would all the DNA in a cell be? 2m long Stretching out all of the DNA in all your 50T cells how many times would it stretch to the moon and back?
  11. 11. What do we know about DNA? How many letters (bases) in the Human Genome? 3 billion basepairs (3Gbp, or 6Gbp if you count we are diploid) Stretching it out, how long would all the DNA in a cell be? 2m long Stretching out all of the DNA in all your 50T cells how many times would it stretch to the moon and back? 100,000 times From: http://www.jpgmonline.com/text.asp?2002/48/3/232/95
  12. 12. Fred Sanger figures out how to read DNA… http://www.cambridge.org/asia/catalogue/catalogue.asp?is bn=9781107083349
  13. 13. So we decided to read it all! Source: http://www.genome.gov/Images/press_photos/highres/38-300.jpg Human Genome Project: 1990-2003. 1 Genome = $3 Billion
  14. 14. Post-Human Genome Project 1st Gen 2nd (next) Gen Source: http://www.genome.gov/sequencingcosts/ Now at $1,000!
  15. 15. Sequencing in the field & clinic for biodiversity studies and medical testing. Produces real-time data, can diagnose infectious disease in minutes. Used during Ebola crisis in W Africa. http://theconversation.com/how-a-small-backpack-for-fast-genomic-sequencing-is-helping- combat-ebola-41863 Not just giant machines. Nanopore sequencing.
  16. 16. So many things you can do with sequencing…study biodiversity http://www.sciencedirect.com/science/article/pii/S0006320714004443 Fig 1. Environmental DNA studies detecting species from environmental samples.
  17. 17. So many things you can do with sequencing…study microbiome You have more microbe than human cells (up to 10x more).
  18. 18. So many things you can do with sequencing…study ancient DNA http://www.nature.com/news/dna-has-a-521-year-half-life-1.11555 Oldest species sequenced to date = 700,000 years old. DNA half life = 521 years. Is Jurassic Park possible? ?
  19. 19. We don’t just read DNA now… Synthetic Biology & Genome Editing From K Chow
  20. 20. Meet Synthia http://www.bbc.com/news/10134341
  21. 21. Meet Synthia The first genome designed by computer. July 2, 2010
  22. 22. What would you like to make with synthetic DNA? How far should this work go? Any ethical concerns?
  23. 23. GENOMICS IN HONG KONG
  24. 24. BGI HK “Chamber O’Illumina’s” Brought HK the worlds largest sequencing
  25. 25. Genomics: something we are good at http://www.theguardian.com/science/2013/sep/01/dennis-lo-prenatal-research-cancer
  26. 26. Why is important? Need people to handle the biggest, "big data" Big Data: Astronomical or Genomical? http://journals.plos.org/plosbiology/article?id=10.1371%2Fjournal.pbio.1002195 "by 2025, it is possible that as many as 25% of the population in developed nations and half of that in less-developed nations will have their genomes sequenced”
  27. 27. Need to build skills & awareness in HK
  28. 28. Brought to you by: HK CUHK …and the people of Hong Kong
  29. 29. An emblematic genome project
  30. 30. A historical mystery that needs solving ? Botanical & Afforestation Department, 1903: "The mysterious origin of the tree and its magnificent flowers at once arrest the interest. … So far, all efforts to identify them with any foreign species have failed" Jean-Marie Delavay
  31. 31. Hybrids: like a Liger? https://en.wikipedia.org/wiki/Liger#/media/File:Liger_couple.jpg
  32. 32. The Hong Kong Orchid: not an orchid
  33. 33. An icon that needs protecting Susceptibility to disease?
  34. 34. Other uses for Bauhinia? Latin name Common name (Nepal) Edible use Other use Bauhinia purpurea Tanki Flowers and young shoots eaten as vegetable. Leaves used as fodder. Bauhinia valii Bhorla Pods eaten as vegetable. Fruits edible. Stem bark used to make ropes. Leaves used to make umbrella Traditional plates for ritual functions. Bark juice used as fermenting material and to cure blood dysentery. Bauhinia variegata Koiralo Young shoots and leaves eaten as vegetable. Flowers eaten as vegetable or used to make pickle. N/A http://bauhiniagenome.hk/get-involved/education/edible-bauhinia/
  35. 35. Tasty Emblem? Eaten in Nepal Recipe: http://bauhiniagenome.hk/get-involved/education/recipe-koirala-achaar/
  36. 36. Help needed assembling the puzzle 600M bp genome Tricky hybrid genome Need to assemble parents first Chemicals cost $10,000 USD Use university student projectshttp://bauhiniagenome.hk/
  37. 37. With Parts Made in (BGI) Hong Kong
  38. 38. A project that needs supporting @bauhiniagenome #bauhinawatch https://www.facebook.com/BauhiniaGenome http://bauhiniagenome.hk/ http://igg.me/at/bauhinia Follow us:
  39. 39. #bauhiniawatch http://bauhiniagenome.hk/wp-content/uploads/2015/11/Bauhinia-identification- table.pdf
  40. 40. #bauhiniawatch http://bauhiniagenome.hk/2015/12/bauhinia-watch-the-movie/
  41. 41. Extract your own DNA – how to guide http://learn.genetics.utah.edu/content/labs/extraction/howto/ http://www.stevespanglerscience.com/lab/experiments/strawberry-dna/
  42. 42. Any Questions?
  43. 43. Extra discussion: Is Bauhinia a GMO?
  44. 44. http://www.geneticliteracyproject.org/2014/06/19/how-your-food-would-look-if-not-genetically-modified-over-millennia/ In a way, all our food has been Genetically Modified
  45. 45. Hybrids are key to agriculture http://www.slideshare.net/hannahreed/selective-breeding-powerpoint

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