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  A new antivirulence approach  against pathogenic bacteria
Corporate overview ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
MUTABILIS’ research objectives ,[object Object],[object Object],[object Object]
Background: Medical need for new anti-infective therapies ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pathogenic bacteria use a range of virulence factors to establish infection Pathogenic bacteria Specific Immunity Innate Immunity Colonization Invasion Shield to immune system Toxins Virulence mechanisms Host defenses Environment adaptation
MUTABILIS’   approach to virulence Systemic infection Selective inhibition of the virulence factors required for systemic dissemination in the host. Gut Blood
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Scientific strategy:
THERAPEUTIC APPROACH:  Antibiotics  versus virulence  inhibitors  ,[object Object],[object Object],[object Object],[object Object],[object Object]
Anti-virulence product profile opens preventive therapy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Virulence inhibition: plan ,[object Object],[object Object],[object Object],[object Object]
Drug discovery ,[object Object],[object Object],[object Object],[object Object]
Anti-virulence product profile opens preventive therapy markets. Healthy individuals Patients at risk of infections Infected patients VACCINATION ANTIVIRULENCE ANTIBIOTICS Specific to the risk of infection ,[object Object],[object Object],[object Object],[object Object],[object Object],Broad spectrum therapy ,[object Object],[object Object],[object Object],[object Object],[object Object],Pathogenic strains Prevention
[object Object],[object Object],[object Object],[object Object],Conclusions: virulence projects
Research area of interest: ,[object Object],[object Object],[object Object],[object Object],[object Object]

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Mutabilis

  • 1. A new antivirulence approach against pathogenic bacteria
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  • 5. Pathogenic bacteria use a range of virulence factors to establish infection Pathogenic bacteria Specific Immunity Innate Immunity Colonization Invasion Shield to immune system Toxins Virulence mechanisms Host defenses Environment adaptation
  • 6. MUTABILIS’ approach to virulence Systemic infection Selective inhibition of the virulence factors required for systemic dissemination in the host. Gut Blood
  • 7.
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  • 11.
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  • 14.